In an effort to greatly expand accessibility, this compact fluorescence-guided surgery system, evaluated in mice, is crafted from cost-effective and off-the-shelf components.
Genetic diversity is key to survival in an everchanging environment. Cancer cells 鈥� thanks to their abundant and eclectic mix of mutations 鈥� unfortunately excel at surviving.聽Drug treatments can diminish tumors for a time but, in many cases, give rise to resistant cells. A different drug may eliminate the resistant population during follow-up treatment only to leave behind a new resistant line that continues to proliferate.
NIH-funded researchers restore facial nerve function in animals with stem cell-based conduits
Releasing a drug selectively in specific locations in the body, including the brain, has been challenging. Researchers at the University of Utah have tackled the problem by designing ultrasound-sensitive nanoparticles that release a drug at the targeted site when activated by focused ultrasound.
NIH awarded more than $4 million in funds and support services to three diagnostic technology developers as part of the RADx Tech鈥檚 Advanced Platforms for HIV Viral Load Monitoring program.
The National Institute of Biomedical Imaging and Bioengineering has designed an initiative called Enhancing Biomedical Engineering, Imaging, and Technology Acceleration (eBEITA) at HBCUs. Recently, NIBIB made its first round of eBEITA grants to two HBCUs.
NIH has announced winners of the RADx庐 Tech Fetal Monitoring Challenge, a $2 million prize competition to speed development of innovative medical technologies for fetal health diagnosis, detection and monitoring.
Typical diagnosis of upper urinary tract cancers requires removal of suspicious tissue with forceps, a technically challenging procedure that only samples one region of the organ. NIBIB-funded researchers are developing preclinical microgrippers that could be deployed throughout the upper urinary tract, which could potentially grab tiny pieces of tissue at hundreds of different areas and someday facilitate early detection of disease.
This feature profiles Parinaz Fathi, Ph.D., an early career researcher at NIBIB, leading an intramural research unit that develops miniature organ models to study immune-related conditions and evaluates the role of biological nanoparticles in autoimmune diseases and cancer. She also creates award-winning scientific art.
NIBIB-funded researchers are working to bring in vivo gene editing to the fore. Through rational engineering of lipid nanoparticles, this collaborative team developed a way to effectively target specific organs in the body to precisely deliver therapeutic cargo, including gene-editing molecules.
As AI is deployed in clinical centers across the U.S., one important consideration is to assure that models are fair and perform equally across patient groups and populations. To better understand the fairness of medical imaging AI, a team of researchers trained over 3,000 models spanning multiple model configurations, algorithms, and clinical tasks.
Cancer cells frequently overhaul their surroundings, making tumors stiffer than nearby healthy tissue. While tumor stiffening makes some cancers easier to detect 鈥� this is why physicians feel for hard lumps in the body 鈥� it can also ramp up tumor growth and drug resistance. New research suggests that these detrimental changes are not set in stone, however.
A lumbar puncture, also known as a spinal tap, can be challenging for physicians to perform manually. A new ultrasound navigation system could provide accurate, real-time, and intuitive needle insertion planning and guidance.
Blueprint MedTech is a National Institutes of Health (NIH) technology incubator program that is part of the NIH Blueprint for Neuroscience Research and for the past two years has provided funding and expertise to fast-track the development of therapeutic and diagnostic devices for disorders that affect the nervous or neuromuscular systems.
A pilot study shows that a new wearable lung sensor combined with deep learning can automatically detect wheezes, a common indicator of asthma and COPD
Physical human feats require a high level of coordination between the sensory functions of our skin and motor functions of our muscles. What kind of achievements could robots perform with the same cohesion between sensing and action? In the medical space, researchers have begun to explore the possibilities.
Now in its 13th year, the annual DEBUT Challenge calls on teams of undergraduate students to identify healthcare problems and develop technological solutions. NIH and VentureWell selected 11 winners and five honorable mentions and will award prizes totaling $160,000.
A team of NIBIB-funded researchers recently developed an AI platform that can analyze 3D pathology images to predict disease outcomes. Their method had improved performance in predicting prostate cancer outcomes when compared with traditional pathology approaches, such as analysis by expert pathologists using 2D images.
Because of its high accuracy, laboratory-based polymerase chain reaction (PCR) testing is the gold standard for infectious disease diagnostics. Yet PCR requires highly trained staff and costly equipment, hindering its availability, especially in low-resource settings. New research suggests a different kind of test could be more streamlined without sacrificing performance.
A team of researchers has established a ribonucleic acid (RNA)-based method that drives cells in the body to produce therapeutic proteins and secrete them into the bloodstream. The approach could potentially extend the lifespan of drugs in the body, reducing the burden on patients who require frequent drug administrations.
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