Credit: Memorial Sloan Kettering Cancer Center
An immunofluorescence image of an aged mouse liver. Expression of β-galactosidase (white) and uPAR (yellow) in senescent cells serve as target for engineered CAR T cells. Elimination of these cells improved age-related metabolic dysfunction.
The ability to improve age-related metabolic dysfunction by targeting senescent cells with engineered CAR T cells was just one of many discoveries made by MSK researchers in 2024.