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News — This work describes a case study conducted via the Accelerating the Pace of Chemical Risk Assessment (APCRA) initiative, a consortium of international research and regulatory scientists, on rapid assessment of data-poor chemicals using a combined battery of new approach methods, including in vitro broad profiling and targeted assays. Using a battery of broad profiling and targeted in vitro assays provided sufficient data to develop an estimate of a threshold dose for any effect, known as a point-of-departure, that is generally protective of traditional, animal-based points-of-departure. Most of these new approach methods-based points of departure were within ± 2 log10-mg/kg/day (a factor of 100) of existing repeated dose point-of-departure data from animal models.