News — A team led by Dr. Hugh Taylor, Chair of the Department of Obstetrics, Gynecology, & Reproductive Sciences at Yale School of Medicine, that microRNAs associated with endometriosis directly impact liver metabolism, resulting in lower BMI and body weight for many women with endometriosis.

"Endometriosis is a common and debilitating disease," Dr. Taylor said. "Our group has demonstrated that there are many systemic effects of the disease outside of the pelvis.  Endometriosis patients on average have a lower BMI, and we have previously shown that endometriosis alters metabolism, including effects on adipose and liver.   Here we demonstrate that the mechanism by which endometriosis effects the liver is by microRNAs.  These small RNA molecules can travel through the circulation and effect the liver.  Knowing the mechanism by which endometriosis alters metabolism open a door to potential treatments by modifying the microRNA signals."

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