News Feature Channel: Autoimmune Diseases

Precision Medicine Uses AI to Predict Protein Kinase Treatment Targets

Sbarro Health Research Organization (SHRO) — Mon, 10 Mar 2025 17:05:44 EST

Protein kinase research presents an opportunity to explore molecular targets in the body to treat diseases like cancer and autoimmune disorders. These enzymes have the potential to bind to cellular sites and inhibit dysfunctional behavior, such as the overproduction of cancerous cells and tumor formation.

New Research Sheds Light on Why Scleroderma Affects Mostly Women and How to Treat It

Hospital for Special Surgery — Thu, 06 Mar 2025 10:00:22 EST

Two new studies led by researchers at Hospital for Special Surgery (HSS) have uncovered key biological mechanisms driving systemic sclerosis (SSc), or scleroderma - a rare and often devastating autoimmune disease that causes fibrosis (tissue hardening) and inflammation. The research, published in the March issue of the Journal of Experimental Medicine, helps explain why the disease disproportionately affects women and reveals potential treatment targets, some of which are already in development.

New Study Supports Caution Regarding Use of Steroids

Johns Hopkins Medicine — Wed, 26 Feb 2025 17:20:33 EST

A new study of hundreds of patient records has added to evidence that it's likely best to use as little corticosteroid medicine as possible when treating people who have lupus, a common heart complication of the autoimmune disorder.

Stopping Asthma in Its Tracks

La Jolla Institute for Immunology — Wed, 19 Feb 2025 20:30:29 EST

"If we can target these molecules in human patients, they might be able to develop long-lasting tolerance to allergens."

Multiple Sclerosis: Cell-Catching Implant Helps Identify Successful Treatment in Mice

University of Michigan — Tue, 18 Feb 2025 19:40:06 EST

A sponge-like implant in mice helped guide a treatment that slowed or stopped a degenerative condition similar to multiple sclerosis in humans. It also gave University of Michigan researchers a first look at how primary progressive multiple sclerosis, the fastest-progressing version of the disease, attacks the central nervous system early on.

Pacientes com doenca de pele respondem a tratamento direcionado

Mayo Clinic — Tue, 04 Feb 2025 08:00:17 EST

Pesquisadores da Mayo Clinic identificaram uma terapia direcionada que pode trazer alivio para as pessoas que vivem com liquen plano, uma condicao inflamatoria cronica da pele, cabelo, unhas, boca e genitais. Eles descreveram suas descobertas em um estudo publicado no Journal of Clinical Investigation, relatando seu primeiro ensaio clinico em humanos, fase 2.

Pacientes con enfermedad de la piel muestran respuesta al tratamiento dirigido

Mayo Clinic — Tue, 04 Feb 2025 06:30:26 EST

Investigadores de Mayo Clinic han identificado una terapia dirigida que puede brindar alivio a las personas que viven con liquen plano, una condicion inflamatoria cronica de la piel, cabello, unas, boca y genitales. Ellos escribieron sus hallazgos en un estudio publicado en el Journal of Clinical Investigation, informando su primer ensayo clinico en humanos, fase 2.

Skin Disease Patients Show Response to Targeted Treatment

Mayo Clinic — Tue, 04 Feb 2025 06:30:21 EST

Mayo Clinic researchers have identified a targeted therapy that could bring relief to people living with lichen planus, a chronic inflammatory skin condition of the skin, hair, nails, mouth and genitals. They described their findings in a study published in the Journal of Clinical Investigation that described their first-in-human, phase 2 clinical trial.

Topical Mupirocin Lowers Lupus Inflammation

Michigan Medicine - University of Michigan — Wed, 29 Jan 2025 21:20:28 EST

Systemic lupus erythematosus, more commonly known as lupus, has a variety of symptoms and room for improvement when it comes to treatment.Cutaneous lupus erythematosus is a common manifestation of systemic lupus erythematosus.The condition is characterized by rashes on various parts of the body including the face and scalp, hair loss and scarring of the skin.

Clinical Trial to Study New Use for CAR T-cell Therapy: Treating Autoimmune Diseases

University of Chicago Medical Center — Tue, 21 Jan 2025 19:45:52 EST

The University of Chicago Medicine has launched a Phase 2 clinical trial to study how CAR T-cell therapy could be used to treat three autoimmune diseases.

Houston Methodist Researchers Identify Key Protein to Potentially Halt Autoimmune Diseases and Allergies

Houston Methodist — Mon, 20 Jan 2025 19:00:15 EST

Houston Methodist researchers have identified a key protein as a potential therapeutic target for stopping the body's immune system from mistakenly attacking itself, offering new hope for treating autoimmune diseases and allergies.

Autoimmune Skin Condition Linked to Higher Risk of Heart Disease

UT Southwestern Medical Center — Mon, 13 Jan 2025 20:50:09 EST

Patients with cutaneous lupus erythematosus (CLE), an autoimmune disease that causes skin inflammation, have a higher risk for atherosclerotic cardiovascular disease (ASCVD), or hardening of the arteries, UT Southwestern Medical Center researchers found. Their study, published in JAMA Dermatology, suggests CLE patients should be screened early for heart disease.

Unexpected Findings in Study of T Cells Considered Front-Line Fighters Against Advanced Melanoma

Yale Cancer Center/Smilow Cancer Hospital — Mon, 02 Dec 2024 09:10:56 EST

Yale researchers made an unexpected discovery--turncoat T cells that help a tumor evade other cancer-fighting immune T cells--in a study of patients living with advanced melanoma that was published Nov. 28 in Nature Immunology.

American Thyroid Association(r) Recognizes 2024 Van Meter Award Winner

American Thyroid Association — Wed, 27 Nov 2024 08:00:56 EST

Carla Moran MB BCh, BAO, PhD awarded the ATA's Van Meter Award for outstanding contributions to thyroid research.

How Long Does It Take to Recover from "Brain on Fire" Disorder?

American Academy of Neurology (AAN) — Wed, 20 Nov 2024 16:00:00 EST

Recovery from an autoimmune inflammation of the brain may take three years or more, according to a study published in the November 20, 2024, online issue of Neurology(r), the medical journal of the American Academy of Neurology.

How New Therapies Are Revolutionizing the Treatment of Juvenile Idiopathic Arthritis

Rutgers University-New Brunswick — Tue, 12 Nov 2024 23:05:50 EST

The use of biologic and targeted therapies for children with juvenile idiopathic arthritis (JIA) surpassed more typical therapies in recent years, according to Rutgers Health researchers.

Two Key Genes Identified Linking Rheumatoid Arthritis and Osteoporosis

American Institute of Physics (AIP) — Tue, 05 Nov 2024 11:00:00 EST

In APL Bioengineering, researchers employed analysis tools and machine learning algorithms to identify two genes linked to rheumatoid arthritis and osteoporosis that could serve as diagnostic tools and potential targets for treatments. Drawing from a large database of genetic information, they gathered dozens of sequenced genomes from people with rheumatoid arthritis and osteoporosis to look for any similarities, using recently developed computational methods to narrow down their search. They identified genes ATXN2L and MMP14 as significantly associated with the progression of both rheumatoid arthritis and osteoporosis.

National Multiple Sclerosis Society Awards $1M to Case Western Reserve University Researchers to Study New Approach to Treat the Disease

Case Western Reserve University — Mon, 04 Nov 2024 08:00:00 EST

Multiple sclerosis (MS) is a debilitating disease of the brain and spinal cord that impacts millions worldwide. In MS, the immune system mistakenly attacks the myelin sheath--a protective layer surrounding nerve cells in the nervous system. The loss of myelin, combined with ongoing inflammation, causes dysfunction and death of nerve cells, making the disability worse, such as difficulties with movement, coordination, and sensation. Treatments now focus on reducing attacks on myelin, but don't address nerve-cell damage and death. But with $1 million from the National Multiple Sclerosis Society (NMSS), a research team co-led by Paul Tesar, the Dr. Donald and Ruth Weber Goodman Professor of Innovative Therapeutics and director of the Institute for Glial Sciences, and Ben Clayton, assistant professor and founding member of the Institute for Glial Sciences, both in the Department of Genetics and Genome Sciences at the Case Western Reserve University School of Medicine, will take a different

Healthy Brains Suppress Inappropriate Immune Responses

Washington University in St. Louis — Wed, 30 Oct 2024 15:00:46 EST

Researchers at WashU Medicine have found a process by which the brain guards against attack by the immune system. In mice with multiple sclerosis, such "guardian" proteins that train the immune system were drastically depleted, and replenishing them improved symptoms, according to a study in Nature.

Youth with Chronic Childhood Arthritis Empowered to Overcome Barriers

University of South Australia — Mon, 28 Oct 2024 21:15:37 EST

A new intervention to help young people with chronic childhood arthritis overcome barriers to physical activity and mental wellbeing will be developed by University of South Australia researchers.