News Feature Channel: Stem Cells

VUMC Part of New Study Validating Curative Therapy for Sickle Cell Disease

Vanderbilt University Medical Center — Tue, 04 Mar 2025 10:50:20 EST

A modified bone marrow transplant procedure for sickle cell disease (SCD) co-developed at Vanderbilt University Medical Center, Johns Hopkins University School of Medicine, and the University of California, San Francisco, can cure the disease, a new study has found.

Research Tip Sheet: New Single-Cell Proteomics Technology Reveals Heart Cell Differences

Cedars-Sinai — Tue, 04 Mar 2025 04:00:20 EST

A multidisciplinary team of Cedars-Sinai investigators has used a novel single-cell proteomics approach to better understand the differences between naturally occurring adult heart cells and heart cells derived from induced pluripotent stem cells.

UC San Diego Innovators to Spotlight Transformative Science at SXSW 2025

University of California San Diego — Mon, 03 Mar 2025 12:00:53 EST

The SXSW Conference will take place from March 7-15 in Austin, Texas, bringing together a vibrant mix of ideas and innovations. Once again, UC San Diego will take center stage, showcasing cutting-edge research, transformative discussions on critical global challenges and a film premiere.

Treatment Strategy Reprograms Brain Cancer Cells, Halting Tumor Growth

University of California, Los Angeles (UCLA), Health Sciences — Wed, 26 Feb 2025 17:25:50 EST

UCLA scientists have identified a potential new strategy for treating glioblastoma, the deadliest form of brain cancer, by reprogramming aggressive cancer cells into harmless ones.

Asthma and Stem Cell Therapy

World Journal of Stem Cells — Wed, 26 Feb 2025 12:00:49 EST

The global incidence of asthma, a leading respiratory disorder affecting more than 235 million people, has dramatically increased in recent years. Characterized by chronic airway inflammation and an imbalanced response to airborne irritants

Fetal Mice Dermal Mesenchymal Stem Cells Promote Wound Healing by Inducing M2 Type Macrophage Polarization

World Journal of Stem Cells — Wed, 26 Feb 2025 12:00:45 EST

BACKGROUNDMesenchymal stem cells, found in various tissues, possess significant healing and immunomodulatory properties, influencing macrophage polarization, which is essential for wound repair. However, chronic wounds present significant t

WDR36 Inhibits the Osteogenic Differentiation and Migration of Periodontal Ligament Stem Cells

World Journal of Stem Cells — Wed, 26 Feb 2025 12:00:41 EST

BACKGROUNDPeriodontitis is an inflammatory disease caused by the host's immune response and various interactions between pathogens, which lead to the loss of connective tissue and bone. In recent years, mesenchymal stem cell (SC) transpla

Effects of Macrophages on the Osteogenic Differentiation of Adipose Tissue-Derived Stem Cells in Two-Dimensional and Three-Dimensional Cocultures

World Journal of Stem Cells — Wed, 26 Feb 2025 12:00:39 EST

BACKGROUNDFracture is one of the most pervasive injuries in the musculoskeletal system, and there is a complex interaction between macrophages and adipose tissue-derived stem cells (ADSCs) in fracture healing. However, two-dimensional (2D)

Impact of miR-214-5p and miR-21-5p From Hypoxic Endometrial Exosomes on Human Umbilical Cord Mesenchymal Stem Cell Function

World Journal of Stem Cells — Wed, 26 Feb 2025 12:00:36 EST

Exosomes derived from hypoxic endometrial epithelial cells are pivotal in cellular communication and tissue repair, offering new perspectives on reproductive health. This manuscript highlights the study by Zhang et al, which investigates th

Induced pluripotent stem cell-derived mesenchymal stem cells for modeling and treating metabolic associated fatty liver disease and metabolic associated steatohepatitis: Challenges and opportunities

World Journal of Stem Cells — Wed, 26 Feb 2025 12:00:34 EST

The potential of induced pluripotent stem cells (iPSCs) for modeling and treating metabolic associated fatty liver disease (MAFLD) and metabolic associated steatohepatitis (MASH) is emerging. MAFLD is a growing global health concern, curren

Perspectives on Schwann-Like Cells Derived From Bone Marrow-Mesenchymal Stem Cells: Advancing Peripheral Nerve Injury Therapies

World Journal of Stem Cells — Wed, 26 Feb 2025 12:00:26 EST

Peripheral nerve injuries are clinical conditions that often result in functional deficits, compromising patient quality of life. Given the relevance of these injuries, new treatment strategies are constantly being investigated. Although me

Stem Cell Therapy: A Promising Therapeutic Approach for Skeletal Muscle Atrophy

World Journal of Stem Cells — Wed, 26 Feb 2025 12:00:24 EST

Skeletal muscle atrophy results from disruptions in the growth and metabolism of striated muscle, leading to a reduction or loss of muscle fibers. This condition not only significantly impacts patients' quality of life but also imposes su

Effect of adipose-derived stem cells exosomes cross-linked chitosan-αβ-glycerophosphate thermosensitive hydrogel on deep burn wounds

World Journal of Stem Cells — Wed, 26 Feb 2025 12:00:08 EST

BACKGROUNDBurn wound management is challenging, and while mesenchymal stem cell-derived exosomes show therapeutic potential, optimal delivery methods are unclear. AIMTo study chitosan (CS)-αβ-glycerophosphate (CS-αβ-GP) hydrogel crossl

Effect of Tandem Autologous Stem Cell Transplantation on Survival in Pediatric Patients with High-Risk Solid Tumors in South China

World Journal of Stem Cells — Wed, 26 Feb 2025 12:00:05 EST

BACKGROUNDDespite advances in treatment, the prognosis for patients with high-risk pediatric solid tumors remains dismal. Tandem autologous stem cell transplantation (ASCT) offers promise for improving outcomes in these patients. This study

Exosomal miR-203 Bone Marrow Stem Cells Targets the SOCS3/NF-κB Pathway to Regulate Neuroinflammation in Temporal Lobe Epilepsy

World Journal of Stem Cells — Wed, 26 Feb 2025 12:00:03 EST

BACKGROUNDEpilepsy is a prevalent chronic neurological disorder affecting 50 million individuals globally, with temporal lobe epilepsy (TLE) being the most common form. Despite advances in antiepileptic drug development, over 30% of patient

Nicotinamide Adenine Dinucleotide Rejuvenates Septic Bone Marrow Mesenchymal Stem Cells

World Journal of Stem Cells — Wed, 26 Feb 2025 12:00:00 EST

BACKGROUNDSepsis is a severe illness characterized by systemic and multiorgan reactive responses and damage. However, the impact of sepsis on the bone marrow, particularly on bone marrow mesenchymal stem cells (BMSCs), is less reported. BMS

New Technique Reveals How the Same Mutations Give Rise to Very Different Types of Leukaemia

Fundacio Institut de Recerca Biomedica (IRB BARCELONA) — Tue, 25 Feb 2025 18:20:00 EST

* A study from IRB Barcelona, funded by Fundacion CRIS contra el cancer demonstrates that the "previous state" of blood stem cells plays a decisive role in the subtype of leukaemia that develops. * The new technique, called STRACK, allows monitoring of the evolution of each cell before and after acquiring oncogenic mutations.

Hormones May Have Therapeutic Potential to Prevent Wrinkles, Hair Graying

Endocrine Society — Tue, 25 Feb 2025 09:00:00 EST

Hormones may be leveraged to treat and prevent signs of aging such as wrinkles and hair graying, according to a new study published in the Endocrine Society journal Endocrine Reviews.

A First: Potential Treatment for Heart Disease Caused by Duchenne Muscular Dystrophy

Cedars-Sinai — Tue, 25 Feb 2025 00:30:28 EST

The FDA is currently evaluating deramiocel, a cell product that is based on discoveries made by Cedars-Sinai's Eduardo Marban, MD, PhD. If approved, deramiocel would be the first treatment for the heart damage that often kills young people with Duchenne muscular dystrophy.

Mount Sinai-Led Research Team Identifies Underlying Mechanisms of Age-Related Dysfunction in Glands Crucial to Eye Function

Mount Sinai Health System — Mon, 24 Feb 2025 10:35:52 EST

A Mount Sinai-led research team has identified underlying mechanisms of age-related dysfunction in glands crucial to eye function, a discovery that may lead to new treatment options for dry eye disease