News Feature Channel: Immunology

Ochsner Transplant Institute Among Site Collaborators in New England Journal of Medicine HIV-to-HIV Kidney Transplant Study

Ochsner Health — Mon, 11 Nov 2024 12:35:58 EST

The article, Safety of Kidney Transplantation from Donors with HIV, details findings supporting HIV-to-HIV kidney transplants as safe and just as effective as those using organs from donors without HIV.

MD Anderson Research Highlights: SITC 2024 Special Edition

University of Texas MD Anderson Cancer Center — Sat, 09 Nov 2024 18:00:16 EST

The University of Texas MD Anderson Cancer Center's Research Highlights showcases the latest breakthroughs in cancer care, research and prevention. These advances are made possible through seamless collaboration between MD Anderson's world-leading clinicians and scientists, bringing discoveries from the lab to the clinic and back.

Polymorphic Positions 349 and 725 of the Autoimmunity-Protective Allotype 10 of ER Aminopeptidase 1 Are Key in Determining Its Unique Enzymatic Properties

National Center For Scientific Research Demokritos — Fri, 08 Nov 2024 12:45:55 EST

ER aminopeptidase 1 (ERAP1) is a polymorphic intracellular aminopeptidase with key roles in antigen presentation and adaptive immune responses. ERAP1 allotype 10 is highly protective toward developing some forms of autoimmunity and displays unusual functional properties, including very low activity versus some substrates.

MD Anderson launches Institute for Cell Therapy Discovery & Innovation to deliver transformational new therapies

University of Texas MD Anderson Cancer Center — Fri, 08 Nov 2024 12:00:57 EST

The University of Texas MD Anderson Cancer Center today announced the launch of its Institute for Cell Therapy Discovery & Innovation, which will build upon longstanding MD Anderson clinical and research expertise to lead the world in developing and advancing impactful cell therapies for patients in need.

Cleveland Clinic Announces Updated Findings in Preventive Breast Cancer Vaccine Study

Cleveland Clinic — Fri, 08 Nov 2024 10:25:35 EST

Cleveland Clinic researchers are presenting updated findings from their novel study of a vaccine aimed at preventing triple-negative breast cancer, the most aggressive and lethal form of the disease. The study team found that the investigational vaccine was generally well tolerated and produced an immune response in most patients. The team described the side effects of the vaccine, showed the highest tolerated dose to date, and presented the immunologic effects of the vaccine. Findings are being presented at the Society for Immunotherapy of Cancer Annual Meeting.

Number of Whooping Cough Cases on Rise Nationally

Vanderbilt University Medical Center — Fri, 08 Nov 2024 09:15:07 EST

Whooping cough is making a comeback, and medical providers say the highly contagious bacterial infection that causes severe coughing fits is preventable. During the COVID-19 pandemic, whooping cough, also known as pertussis, declined dramatically.

Researchers Make Glioblastoma Cells Visible to Attacking Immune Cells

Washington University in St. Louis — Thu, 07 Nov 2024 13:15:09 EST

Researchers at WashU Medicine have identified a possible way to make glioblastoma cells vulnerable to different types of immunotherapy. The strategy, which they demonstrated in cells in the lab, forces brain cancer cells to display targets for the immune system to attack. Their study was published in Nature Genetics.

Researchers Find Metabolic Mechanism That Blocks Immune Response, Immunotherapy in Cancer

Michigan Medicine - University of Michigan — Thu, 07 Nov 2024 11:50:30 EST

Researchers at the University of Michigan Rogel Cancer Center have discovered a key reason why some cancers do not respond to immunotherapy: A metabolite transporter within the tumor microenvironment that blocks a key type of tumor cell death integral to immune response.

A Gut Feeling About HIV and Heart Disease

Cedars-Sinai — Thu, 07 Nov 2024 10:20:15 EST

Ivan Vujkovic-Cvijin, PhD, is a pioneer in the study of the gut microbiota and the surprising ways these microorganisms living in our digestive tracts affect our overall health. His discoveries have been featured in Nature, Science Translational Medicine, Cell Reports and other top scientific journals.

New Guidelines for Insurers Help Patients Receive Necessary Allergen Immunotherapy Treatment

American College of Allergy, Asthma and Immunology (ACAAI) — Wed, 06 Nov 2024 13:00:27 EST

Newly-published guidance from the American College of Allergy, Asthma & Immunology (ACAAI), the American Academy of Allergy, Asthma & Immunology (AAAAI) and the American Academy of Otolaryngic Allergy (AAOA) provides useful recommendations to insurance companies regarding appropriate documentation requirements for allergen immunotherapy.

MSK Research Highlights, November 6, 2024

Memorial Sloan Kettering Cancer Center — Wed, 06 Nov 2024 11:35:15 EST

New MSK research marks a potential advance against RAS-driven cancers; breaks down data silos to better predict cancer outcomes with the help of artificial intelligence (AI); identifies two enzymes vital for maintaining brain health; uncovers how changes to "helper" proteins drive cancer cell survival; develops a new model for investigating lung cancer metastasis; and uses AI to improve outcome predictions in sarcoma.

Rutgers Study Reveals Vaccination Patterns Among LGBTQ+ Adults in New Jersey and New York

Rutgers University-New Brunswick — Tue, 05 Nov 2024 23:20:55 EST

A new study led by Rutgers Health researchers has uncovered important insights into vaccination patterns among LGBTQ+ adults in New Jersey and New York. The findings, published in the journal Vaccine, shed light on disparities in vaccine uptake within this diverse population.

Two Key Genes Identified Linking Rheumatoid Arthritis and Osteoporosis

American Institute of Physics (AIP) — Tue, 05 Nov 2024 11:00:00 EST

In APL Bioengineering, researchers employed analysis tools and machine learning algorithms to identify two genes linked to rheumatoid arthritis and osteoporosis that could serve as diagnostic tools and potential targets for treatments. Drawing from a large database of genetic information, they gathered dozens of sequenced genomes from people with rheumatoid arthritis and osteoporosis to look for any similarities, using recently developed computational methods to narrow down their search. They identified genes ATXN2L and MMP14 as significantly associated with the progression of both rheumatoid arthritis and osteoporosis.

Moffitt Study Links Methylmalonic Acid to Weakening of Immune Cells in Lung Cancer

Moffitt Cancer Center — Thu, 31 Oct 2024 14:05:32 EST

A new study has found a surprising link between high levels of methylmalonic acid and the weakening of CD8+ T cells, shedding light on potential pathways through which aging may promote lung cancer progression. Moffitt Cancer Center researchers have found new insights into how metabolic changes associated with aging can impact immune responses against tumors.

New Findings on Animal Viruses with Potential to Infect Humans

Ohio State University — Thu, 31 Oct 2024 12:20:10 EST

Scientists investigating animal viruses with potential to infect humans have identified a critical protein that could enable spillover of a family of organisms called arteriviruses.

Healthy Brains Suppress Inappropriate Immune Responses

Washington University in St. Louis — Wed, 30 Oct 2024 15:00:46 EST

Researchers at WashU Medicine have found a process by which the brain guards against attack by the immune system. In mice with multiple sclerosis, such "guardian" proteins that train the immune system were drastically depleted, and replenishing them improved symptoms, according to a study in Nature.

MD Anderson Research Highlights for October 30, 2024

University of Texas MD Anderson Cancer Center — Wed, 30 Oct 2024 12:00:04 EST

Complexity of Tumors Revealed in 3D

Washington University in St. Louis — Wed, 30 Oct 2024 12:00:00 EST

A new analysis led by researchers at Washington University School of Medicine in St. Louis has revealed detailed 3D maps of the internal structures of multiple tumor types. These cancer atlases reveal how different tumor cells -- and the cells of a tumor's surrounding environment -- are organized, in 3D, and how that organization changes when a tumor spreads to other organs. The detailed findings offer scientists valuable blueprints of tumors that could lead to new approaches to therapy and spark a new era in the field of cancer biology, according to the researchers.

Computational Tool Developed to Predict Immunotherapy Outcomes for Patients With Metastatic Breast Cancer

Johns Hopkins Medicine — Tue, 29 Oct 2024 14:00:06 EST

Using computational tools, researchers from the Johns Hopkins Kimmel Cancer Center and the Johns Hopkins University School of Medicine have developed a method to assess which patients with metastatic triple-negative breast cancer could benefit from immunotherapy.

Update: San Diego scientist available to comment on dengue vaccine research -- following report of second locally transmitted dengue case

La Jolla Institute for Immunology — Tue, 29 Oct 2024 12:25:35 EST