News Feature Channel: Transplantation

Ochsner Transplant Institute Among Site Collaborators in New England Journal of Medicine HIV-to-HIV Kidney Transplant Study

Ochsner Health — Mon, 11 Nov 2024 12:35:58 EST

The article, Safety of Kidney Transplantation from Donors with HIV, details findings supporting HIV-to-HIV kidney transplants as safe and just as effective as those using organs from donors without HIV.

Lurie Children's Transplant Expertise Shines in Record-Breaking Year

Ann and Robert H. Lurie Children's Hospital of Chicago — Thu, 07 Nov 2024 12:00:58 EST

Lurie Children's surpassed a hospital record in its recent fiscal year by performing a record 140 pediatric transplants, including, heart, kidney, liver and stem cell.

Johns Hopkins Medicine Study Expands Understanding of How Fecal Microbiota Transplants May Work to Restore Gut Health

Johns Hopkins Medicine — Wed, 06 Nov 2024 10:00:53 EST

In a novel study that identified male chromosome genetic material in the intestines of female patients undergoing fecal transplants, researchers at Johns Hopkins Medicine say they have significantly expanded scientific understanding of how some of these transplants may succeed and work.

Ivan Maillard Named Head of the Division of Hematologic Malignancies at Memorial Sloan Kettering Cancer Center

Memorial Sloan Kettering Cancer Center — Mon, 04 Nov 2024 10:00:00 EST

Ivan Maillard, MD, PhD, has been named Head of the Division of Hematologic Malignancies within the Department of Medicine at Memorial Sloan Kettering Cancer Center (MSK).

SynCardia Granted Second Patent Covering Fully Implantable Artificial Heart

SynCardia Systems, LLC — Thu, 31 Oct 2024 08:10:07 EST

SynCardia Systems, LLC., a Picard Medical Inc. company, is pleased to announce that the United States Patent and Trademark Office (USPTO) has issued a second patent (US patent no. 12,121,711 B2) that will expand the coverage of SynCardia's fully implantable artificial heart technology (SynCardia Emperor). The USPTO allowed the first patent (US patent no. 11,918,797) relating to its groundbreaking "Next Generation Total Artificial Heart" designs in March of this year.

New Study Refines Understanding of Kidney Transplant Rejection

Rutgers University-New Brunswick — Mon, 28 Oct 2024 14:15:27 EST

Findings from Rutgers Health and other researchers may lead to more precise treatment.

Advancing Care of a Devastating Disease Through Gene Therapy

University of California, San Francisco (UCSF) — Mon, 28 Oct 2024 07:00:38 EST

A new international trial is investigating the efficacy and safety of gene therapy in patients with Hurler syndrome and will compare results of gene therapy against BMT which is the current standard of care. UCSF Benioff Children's Hospitals are among three sites in the U.S. and seven in the world now enrolling patients for the clinical trial.

Prabir Roy-Chaudhury, MD, PhD, FASN, to Become Next President of the American Society of Nephrology

American Society of Nephrology (ASN) — Sun, 27 Oct 2024 12:00:00 EST

Dr. Roy-Chaudhury will head up an organization--with nearly 21,000 health professionals representing 140 countries--dedicated to leading the fight against kidney diseases.

Trial Assesses Antibody Therapy for Chronic Active Antibody-Mediated Kidney Transplant Rejection

American Society of Nephrology (ASN) — Sat, 26 Oct 2024 19:30:00 EST

Chronic active antibody-mediated rejection (caAMR) is a common cause of allograft loss after transplantation, with no approved therapies. Clazakizumab, a monoclonal antibody that targets the inflammatory cytokine interleukin-6 (IL-6), stabilized kidney transplant recipients' kidney function in a phase 2 trial. Investigators now have data from a phase 3 trial with clazakizumab. The findings from the Phase 3 IMAGINE trial, the largest placebo-controlled study in kidney transplant recipients with caAMR, will be presented at ASN Kidney Week 2024 October 23- 27.

Researchers Test Imlifidase Enzyme Versus Plasma Exchange in Removing Donor-Specific Antibodies in Kidney Transplant Rejection Trial

American Society of Nephrology (ASN) — Sat, 26 Oct 2024 19:30:00 EST

For kidney transplant recipients experiencing antibody-mediated rejection, the current standard of care involves removing donor-specific antibodies (DSAs) through plasmapheresis (PLEX)--a procedure that removes antibodies from the plasma portion of the blood. Results from a recent clinical trial reveal that an investigational drug called imlifidase, which cleaves and inactivates the type of antibodies that include DSAs, is more effective than PLEX. The research will be presented at ASN Kidney Week 2024 October 23-27.

Heart and Kidney Outcomes After Canagliflozin Treatment in Older Adults

American Society of Nephrology (ASN) — Fri, 25 Oct 2024 19:30:00 EST

Sodium-glucose co-transporter 2 (SGLT2) inhibitors reduce the risk of cardiovascular and kidney outcomes in patients with type 2 diabetes, but it is unclear whether their effects differ based on patients' age. A recent analysis of clinical trial data reveals that the SGLT2 inhibitor canagliflozin benefited patients across all age categories. The findings will be presented at ASN Kidney Week 2024 October 23 - 27.

How the Novel Antibody Felzartamab Impacts IgA Nephropathy

American Society of Nephrology (ASN) — Fri, 25 Oct 2024 19:30:00 EST

IgA nephropathy (IgAN) is an autoimmune kidney disease driven by immune cells that express a protein called CD38 on their surface. A recent Phase 2 trial revealed that felzartamab, an investigational anti-CD38 monoclonal antibody, helps to reduce proteinuria and maintain patients' kidney function. Investigators evaluated the molecular mechanisms underlying felzartamab's potential efficacy in IgAN. The findings will be presented at ASN Kidney Week 2024 October 23- 27.

Researchers Integrate Multiple Protein Markers to Predict Health Outcomes in Individuals with Chronic Kidney Disease

American Society of Nephrology (ASN) — Fri, 25 Oct 2024 19:30:00 EST

Prior efforts to identify novel kidney biomarkers as risk factors for chronic kidney disease (CKD) progression have typically evaluated proteins individually, which limits their prognostic power. The National Institute of Diabetes and Digestive and Kidney Diseases' (NIDDK's) CKD Biomarkers Consortium of investigators recently developed and tested novel dimensions of kidney health by combining a set of 17 urine and plasma biomarkers that had been individually associated with CKD progression. The research will be presented at ASN Kidney Week 2024 October 23- 27.

Do Certain Diabetes Drugs Increase the Risk of Acute Kidney Injury in Patients Taking Anti-Cancer Therapies?

American Society of Nephrology (ASN) — Fri, 25 Oct 2024 19:30:00 EST

Glucagon-like peptide-1-receptor agonists (GLP-1RA) are medications that are increasingly prescribed for patients with type 2 diabetes and congestive heart failure. Reports of GLP-1RA-associated acute kidney injury (AKI) have emerged, but the risk of GLP-1RA-associated AKI among patients on anti-cancer drugs is unclear. Surprisingly, new research suggests that taking GLP-1RA is not associated with an increased risk of AKI in patients receiving anti-cancer therapies. The findings will be presented at ASN Kidney Week 2024 October 23- 27.

Kidney Week 2024 Special Media Event: Insights on Rapidly Evolving Kidney Transplant Policy Landscape

American Society of Nephrology (ASN) — Thu, 24 Oct 2024 20:15:00 EST

On Thursday, Oct. 24 from 4:30-5:15 PM PT (7:30-8:15 PM ET), ASN will host an open-format discussion session - for media only - featuring several of the world's leading transplant nephrology researchers, care providers, and public policy experts.

The Clinical Significance of Microvascular Inflammation after Kidney Transplantation

American Society of Nephrology (ASN) — Thu, 24 Oct 2024 19:30:00 EST

Investigators recently uncovered key insights into newly defined rejection entities in kidney transplantation that may offer improved patient risk categorization post-transplant. The research will be presented at ASN Kidney Week 2024 October 23- 27.

Johns Hopkins Children's Center Research in Mice Suggests Zinc Supplements Have Potential Value to Directly Treat Short Bowel Syndrome

Johns Hopkins Medicine — Thu, 24 Oct 2024 14:30:03 EST

Researchers from Johns Hopkins Children's Center say they have identified a gene pathway involving the mineral zinc in mice that may someday point the way to using zinc-based supplements to directly help people with a rare disorder called short bowel syndrome (SBS).

Mayo Clinic Performs Its First Paired Living Liver Donation

Mayo Clinic — Wed, 23 Oct 2024 10:50:17 EST

Surgeons recently performed Mayo Clinic's first paired living liver donation, a significant first step in helping more people with liver failure get a lifesaving transplant.

World's First Subzero Organ Transports: Multiple 48-Hour Transatlantic Journeys Support First Steps Toward Tackling Organ Waitlist

X-Therma Inc. — Wed, 23 Oct 2024 09:10:34 EST

In a world first, a pig kidney preserved at subzero temperatures was successfully transported across the Atlantic Ocean multiple times, demonstrating the potential for a novel technology to greatly extend organ storage and preservation, and make long-distance organ transportation a clinical reality.

Improving Organ Transplant Donations Through a National Strategy

Michigan Medicine - University of Michigan — Wed, 23 Oct 2024 09:10:29 EST

Across the United States, around 100,000 organ donations are needed each year and an average of 28,000 transplants are performed across the country. Despite the ongoing need for donated organs for transplant, many donated organs end up being discarded for various reasons.