News Curated �鶹��ý Channel: NEJM

New brain-computer interface allows man with ALS to 'speak' again

UC Davis Health — Wed, 14 Aug 2024 16:05:24 EST

A brain-computer interface developed by UC Davis Health accurately translates brain signals into speech. The device implanted in the brain of a man with ALS is the most accurate system of its kind.

FDA Approves Drug Targeting Johns Hopkins-Discovered Brain Cancer Gene Mutation

Johns Hopkins Medicine — Wed, 07 Aug 2024 09:05:33 EST

A new drug for treatment of a type of brain cancer, called IDH-mutant low-grade glioma, was approved Aug. 6 by the U.S. Food and Drug Administration (FDA). The promising new drug stems from a 2008 genetic discovery made at the Johns Hopkins Kimmel Cancer Center.

Phase 3 Clinical Trial Shows Benefits of a New Treatment for Children With Congenital Adrenal Hyperplasia

Children's Hospital Los Angeles — Tue, 30 Jul 2024 09:05:48 EST

When it comes to caring for children with congenital adrenal hyperplasia (CAH), avoiding the side effects of traditional treatments has long been a challenge. But in a recent phase 3 clinical trial, a new drug called crinecerfont showed safety and efficacy in children with classic CAH, the severe form of this condition.

Nueva investigacion descubre una nueva combinacion de terapia para personas con un tipo de leucemia, lo que les permite vivir mas tiempo

Mayo Clinic — Mon, 29 Jul 2024 11:05:57 EST

En un nuevo estudio multicentrico internacional dirigido por el Centro Oncologico Integral de Mayo Clinic, investigadores encontraron que las personas con el subtipo de leucemia linfoblastica aguda precursores de celulas B (LLA-BCP), que tampoco presentaban una anomalia genetica conocida como cromosoma Filadelfia y que estaban en remision y sin rastros de cancer, mostraron tasas de supervivencia significativamente mas altas cuando se agrego blinatumomab al tratamiento de quimioterapia.

بحث جديد يكتشف مزيجًا علاجيًا للمصابين بأحد أنواع ابيضاض الدم (لُوكيميا) يطيل بقائهم على قيد الحياة

Mayo Clinic — Mon, 29 Jul 2024 11:05:35 EST

في دراسة دولية جديدة متعددة المراكز بقيادة مركز مايو كلينك الشامل للسرطان، وجد الباحثون أن الأشخاص المصابين بالنوع الفرعي من سلائف الخلايا البائية من ابيضاض الدم (لُوكيميا) بالأرومات اللِّمفاوية الحادّ، والذين أيضًا كانوا يفتقرون إلى خلل وراثي يعرف باسم كروموسوم فيلادلفيا وكانوا في فترة هدأة دون أي أثر للسرطان، أظهروا معدلات بقاء على قيد الحياة أعلى بشكل ملحوظ عندما أُضيف بليناتوموماب إلى علاجهم الكيميائي. تُنشر نتائج الدراسة العشوائية هذا الشهر في مجلة نيو إنجلاند الطبية (The New England Journal of Medicine).

Nova pesquisa descobre uma nova combinacao de terapia para pessoas com um tipo de leucemia, permitindo que elas vivam mais

Mayo Clinic — Mon, 29 Jul 2024 11:05:30 EST

Em um novo estudo multicentrico internacional liderado pelo Centro Oncologico Integral da Mayo Clinic, pesquisadores descobriram que pessoas com o subtipo de leucemia linfoblastica aguda de precursor de celulas B (LLA-BCP), que tambem nao apresentavam uma anomalia genetica conhecida como cromossomo Filadelfia e que estavam em remissao e sem vestigios de cancer, mostraram taxas de sobrevivencia significativamente mais elevadas quando o blinatumomab foi adicionado ao tratamento quimioterapico.

New research discovers a new combination of therapy for people with a type of leukemia, leading them to live longer

Mayo Clinic — Wed, 24 Jul 2024 17:05:27 EST

In a new multicenter international study led by the Mayo Clinic Comprehensive Cancer Center, researchers found that people with the B-cell precursor subtype of acute lymphoblastic leukemia (BCP-ALL), who also lacked a genetic abnormality known as the Philadelphia chromosome and were in remission with no trace of cancer, showed significantly higher survival rates when blinatumomab was added to their chemotherapy treatment.

Decoding Early Lyme Disease

Rutgers University-New Brunswick — Tue, 23 Jul 2024 10:00:00 EST

A Rutgers Health physician-scientist publishes guidance for primary care doctors diagnosing and treating early Lyme disease, a bacterial infection

Risk of long COVID declined over course of pandemic

Washington University in St. Louis — Wed, 17 Jul 2024 17:00:00 EST

The risk of long COVID has declined over the course of the pandemic, although it remains a persistent threat. Researchers from Washington University School of Medicine in St. Louis identified vaccination as a primary factor in reducing the risk of long COVID.

George Bakris, internationally recognized hypertension expert, 1952-2024

University of Chicago Medical Center — Thu, 11 Jul 2024 17:05:35 EST

Bakris served on the UChicago faculty for 18 years and was director of the Comprehensive Hypertension Center.

Cedars-Sinai AI Expert Makes Case for Importance of Thoughtful Model Design

Cedars-Sinai — Thu, 11 Jul 2024 11:05:49 EST

The data fed to artificial intelligence (AI) systems make all the difference on performance, according to David Ouyang, MD, a cardiologist in the Department of Cardiology in the Smidt Heart Institute at Cedars-Sinai.

Electroconvulsive therapy or ketamine? Clinical factors affect outcomes

UT Southwestern Medical Center — Tue, 25 Jun 2024 11:05:21 EST

Patients with moderate to severe treatment-resistant depression (TRD) might have better symptom relief from ketamine infusions than from electroconvulsive therapy (ECT), but those with severe TRD could benefit more from ECT early in treatment, an analysis led by a UT Southwestern Medical Center researcher shows. The findings, published in JAMA Network Open, are the first to identify characteristics that distinguish which treatments might benefit TRD patients more.

Study Identifies First Drug Therapy for Sleep Apnea

UC San Diego Health — Fri, 21 Jun 2024 15:45:00 EST

UC San Diego School of Medicine international study shows new drug improves sleep, health in patients diagnosed with obesity and sleep apnea.

Global trial confirms benefit of antacids on bleeding prevention for ventilated patients

McMaster University — Fri, 14 Jun 2024 10:40:00 EST

Critically ill patients are at risk of stress-induced upper gastrointestinal bleeding. Now, a global trial led by McMaster University researchers confirms that a widely available drug does prevent upper gastrointestinal bleeding.

Multicenter Randomized Trial Identifies Method of Preoxygenation That Prevents Hypoxemia and Cardiac Arrest During Emergency Tracheal Intubation

Vanderbilt University Medical Center — Thu, 13 Jun 2024 08:00:00 EST

Vanderbilt University Medical Center (VUMC) led the Department of the Defense-funded Pragmatic Trial Examining Oxygenation Prior to Intubation PREOXI study comparing the two most commonly used methods used to preoxygenate patients prior to tracheal intubation: preoxygenation with noninvasive ventilation and preoxygenation with an oxygen mask.

Case study reveals important new details about rare second cancers related to CAR-T therapy

Georgetown University Medical Center — Wed, 12 Jun 2024 17:00:00 EST

A new detailed analysis of a patient's second cancer after receiving CAR-T therapy for the initial cancer provides rare but important insights intended to offer helpful guidance for oncologists and pathologists about the clinical presentation and pathologic features involved in a CAR-T related second cancer.

Team tests strategies to care for patients with multiple diseases

UT Southwestern Medical Center — Tue, 11 Jun 2024 10:05:29 EST

In a large clinical trial, UT Southwestern Medical Center researchers developed a robust model for testing strategies to prevent health problems in patients with multiple chronic conditions.

RNA Inhibitor Is Shown Safe and Effective in Reducing a Wide Range of Cholesterol and Triglyceride Levels in the Blood in Mount Sinai-Led Clinical Trial

Mount Sinai Health System — Wed, 29 May 2024 05:30:32 EST

A small interfering RNA (siRNA) investigational therapy that inhibits a gene involved in lipoprotein metabolism has been shown in a clinical trial led by Mount Sinai researchers to significantly reduce levels of different types of cholesterol and triglycerides in individuals with mixed hyperlipidemia, a condition in which fats build up in the blood.

Raw milk containing H5N1 can infect mice, while lab-based heat treatments greatly reduce the virus

University of Wisconsin-Madison — Fri, 24 May 2024 10:05:08 EST

Consuming raw cow's milk that contains H5N1 avian influenza virus poses an infection risk, but a laboratory process that simulates high-temperature pasteurization reduces the virus in infected milk by more than 99.99%. That's according to a team led by University of Wisconsin-Madison scientists, who reported their findings May 24 in a letter published in the New England Journal of Medicine.

Measuring Lung Function More Accurately and More Equitably

Harvard Medical School — Sun, 19 May 2024 09:00:00 EST

Race-based assessments of lung function have historically assumed different levels of "normal" for different patient groups. New analysis shows that removing from lung function estimates would increase the number of Black patients diagnosed with serious disease.Greater estimated disease severity would change a patient's diagnosis, disability compensation, eligibility for certain jobs.