News Curated �鶹��ý Channel: Cell (journal)

A Newly Developed Algorithm Shows How a Gene Is Expressed at Microscopic Resolution

Michigan Medicine - University of Michigan — Thu, 31 Oct 2024 13:50:05 EST

A new method developed by University of Michigan researchers creates images that are worth many gigabytes of data, which could revolutionize the way biologists study gene expression.

Study Identifies How Ovarian Cancer Protects Itself, Paves Way for Improved Immunotherapy Approach

Mount Sinai Health System — Wed, 30 Oct 2024 11:00:00 EST

Researchers at the Icahn School of Medicine at Mount Sinai have discovered a way that ovarian cancer tumors manipulate their environment to resist immunotherapy and identified a drug target that could overcome that resistance. The study, published in the October 30 online issue of Cell used a cutting-edge spatial genomics technology and preclinical animal models, with tumor specimens from ovarian cancer patients further validating the findings. They found that ovarian cancer cells produce a molecule called Interleukin-4 (IL-4), which is typically associated with asthma and the skin condition eczema, also known as atopic dermatitis. The study went on to find that the cancer cells used IL-4 to create a protective environment that kept away killer immune cells, making the tumors resistant to immunotherapy. A drug, dupilumab, which blocks IL-4's activity, has been approved by the Food and Drug Administration (FDA) and is already used to treat asthma and eczema. This new study suggests dupi

A New Chemistry for CRISPR

Rockefeller University — Mon, 28 Oct 2024 12:30:10 EST

It acts as a sort of molecular fumigator to battle phages and plasmids.

New Research Offers Hope for Treating Inherited Peripheral Neuropathies

Uniformed Services University of the Health Sciences (USU) — Tue, 22 Oct 2024 12:10:09 EST

A recent study published by Dr. Jordan Verplank, Assistant Professor in the Department of Anatomy, Physiology, and Genetics at the Uniformed Services University of the Health Sciences (USU), and a team of scientists from USU, State University of Buffalo (New York), and Cyclerion Therapeutics, has identified a promising approach for treating hereditary peripheral neuropathies, specifically Charcot Marie Tooth disease types 1A (CMT1A) and 1B (CMT1B). By focusing on increasing levels of cyclic guanosine monophosphate (cGMP) - a signaling molecule involved in various biological processes - the study has shown potential improvements in myelination, nerve conduction, and motor coordination in mouse models affected by these conditions. The findings were published in Cellular and Molecular Life Sciences on October 14, 2024.

Researchers Help Redefine Core Microbiome, Opening New Chapter in Precision Health

Rutgers University-New Brunswick — Wed, 16 Oct 2024 12:25:33 EST

Researchers at Rutgers University-New Brunswick, along with international collaborators, have introduced a novel method for identifying the crucial set of gut microbes commonly found in humans and essential for health.

Study Explores Novel Therapeutic Treatment for Glioblastoma

Ohio State University Wexner Medical Center — Mon, 07 Oct 2024 15:05:53 EST

Researchers with The Ohio State University Comprehensive Cancer Center - Arthur G. James and Richard J. Solove Research Institute are trying to improve outcomes for patients with a deadly form of brain cancer known as glioblastoma.

Scientists Discover That Special Immune Cells Stop Metastatic Cancer

Montefiore Einstein Comprehensive Cancer Center — Mon, 07 Oct 2024 11:00:00 EST

A research team at the National Cancer Institute-designated Montefiore Einstein Comprehensive Cancer Center (MECCC) has discovered a natural immune mechanism in mice that stops escaped cancer cells from developing into tumors elsewhere in the body. The findings were published today in the journal Cell.

Moffitt Study Unveils the Role of Gamma-Delta T Cells in Cancer Immunology

Moffitt Cancer Center — Fri, 04 Oct 2024 12:00:07 EST

TAMPA, Fla. - A new study published in Cell Press reveals critical insights into the role of gamma-delta T cells across 33 cancer types, shedding light on their potential as clinical biomarkers and therapeutic targets in cancer treatment. Led by a team of researchers at Moffitt Cancer Center, this comprehensive analysis represents a significant advancement in the understanding of these unique immune cells and their implications for patient outcomes in cancer therapy.

Research Points to Potential New Treatment for Aggressive Prostate Cancer Subtype

Michigan Medicine - University of Michigan — Fri, 04 Oct 2024 11:00:00 EST

In two new papers, both published in Cell Reports Medicine, researchers from the University of Michigan Rogel Cancer Center describe the mechanisms of how alterations in the CDK12 gene drive prostate cancer development and report on a promising degrader that targets CDK12 and a related gene to destroy tumors.

New Barcode Technology Could Help Diagnose Cancer More Precisely

Yale Cancer Center/Smilow Cancer Hospital — Mon, 30 Sep 2024 11:05:51 EST

A new pathology tool created at Yale harnesses barcode technology and shows potential for use in cancer diagnoses. The technology, Patho-DBiT (pathology-compatible deterministic barcoding in tissue), was discussed in a new study that published Sept. 30 in the journal Cell. Co-corresponding author Dr. Mina Xu, a Yale Cancer Center (YCC) member, professor of pathology at Yale School of Medicine (YSM), and the YSM director of hematopathology, shared her enthusiasm for the new tool.

Organoids Derived From Gut Stem Cells Reveal Two Distinct Molecular Subtypes of Crohn's Disease

University of California San Diego — Thu, 26 Sep 2024 11:00:00 EST

UC San Diego researchers discover two distinct molecular subtypes of Crohn's disease using patient-derived organoids, opening the door to personalized treatment for the chronic inflammatory bowel disease.

MSK Research Highlights September 18, 2024

Memorial Sloan Kettering Cancer Center — Wed, 18 Sep 2024 11:05:31 EST

New research from Memorial Sloan Kettering Cancer Center (MSK) uses saturation genome editing to better understanding of the RAD51C gene, which has been linked to higher risks of breast and ovarian cancer; sheds new light on brain metastasis; and finds a commercially available contrast dye could help surgeons better separate cancer from healthy tissue.

'Time for a Paradigm Shift' in Depression Research

UT Southwestern Medical Center — Wed, 18 Sep 2024 08:00:52 EST

LJI Discovery Paves the Way for Antivirals Against Ebola Virus and Its Deadly Relatives

La Jolla Institute for Immunology — Tue, 17 Sep 2024 17:05:16 EST

The new study, led by researchers in the Saphire Lab at LJI, reveals the inner workings of the Ebola virus nucleocapsid. LA JOLLA, CA--At this moment, the world has few tools to combat deadly filoviruses, such as Ebola and Marburg viruses. The only approved vaccine and antibody treatments protect against just one filovirus species.

Researchers uncover shared cellular mechanisms across three major dementias

University of California, Los Angeles (UCLA), Health Sciences — Wed, 11 Sep 2024 11:00:00 EST

Researchers have for the first time identified degeneration-associated "molecular markers" - observable changes in cells and their gene-regulating networks - that are shared by several forms of dementia that affect different regions of the brain.

Researchers uncover new infection-fighting molecules through "molecular de-extinction"

Perelman School of Medicine at the University of Pennsylvania — Wed, 11 Sep 2024 11:00:00 EST

New Study Shows that Chronic Neurodegeneration can be Prevented after Traumatic Brain Injury

University Hospitals Cleveland Medical Center — Tue, 10 Sep 2024 09:05:28 EST

Violent blows or jolts to the head can cause traumatic brain injury (TBI), and there are currently about five million people in the U.S. living with chronic neurodegeneration and related impairments due to TBI.

Researchers at UCLA Identify Cellular Pathways Whose Dysregulation Leads to Acne Lesions

University of California, Los Angeles (UCLA), Health Sciences — Mon, 09 Sep 2024 16:05:49 EST

Using cutting-edge bioinformatics techniques for gene identification and sequencing, researchers at UCLA are comprehensively map signaling pathway distributions in both normal and acne-affected skin.

Pathway Tied to Cancer-Driving Genome Alterations Identified

UT Southwestern Medical Center — Mon, 09 Sep 2024 11:05:40 EST

Cancer cells appear to hijack a genetic pathway involved in DNA repair to drive malignancy and overcome treatment, a study led by UT Southwestern Medical Center researchers shows. Their findings, published in Cell, explain how chromosomes in some tumors undergo massive rearrangements and could lead to new strategies to avoid cancer drug resistance.

Urate Transporter Structures Reveal the Mechanism Behind Important Drug Target for Gout

St. Jude Children's Research Hospital — Mon, 09 Sep 2024 11:05:22 EST

Ten structures of URAT1 obtained by scientists at St. Jude Children's Research Hospital provide a deep understanding of the mechanism of urate transport to guide gout therapeutic design.