News Feature Channel: Clinical Trials

Treatment Advances, Predictive Biomarkers Stand to Improve Bladder Cancer Care

University of North Carolina Health Care System — Wed, 13 Nov 2024 17:00:00 EST

Recent advances in bladder cancer treatments may offer hope of curative care to more patients, including those with high-risk localized, muscle-invasive disease, according to a New England Journal of Medicine editorial published by Matthew Milowsky, MD, FASCO, a bladder cancer expert at UNC School of Medicine and UNC Lineberger Comprehensive Cancer Center.

MRI-Guided Radiation Therapy Reduces Long-Term Side Effects for Patients with Prostate Cancer

University of California, Los Angeles (UCLA), Health Sciences — Wed, 13 Nov 2024 12:35:54 EST

After a comprehensive two-year follow-up, researchers at the UCLA Health Jonsson Comprehensive Cancer Center found that MRI-guided stereotactic body radiotherapy (SBRT) for prostate cancer significantly reduced long-term side effects and improved quality of life, particularly in bowel and sexual health, compared to conventional CT-guided treatment.

How New Therapies Are Revolutionizing the Treatment of Juvenile Idiopathic Arthritis

Rutgers University-New Brunswick — Tue, 12 Nov 2024 23:05:50 EST

The use of biologic and targeted therapies for children with juvenile idiopathic arthritis (JIA) surpassed more typical therapies in recent years, according to Rutgers Health researchers.

Gene Therapy Protects Against Motor Neuron Disease in Rats

University of Wisconsin-Madison — Tue, 12 Nov 2024 11:30:51 EST

University of Wisconsin-Madison researchers targeting a group of hereditary neurodegenerative diseases have found success using a gene therapy treatment in an animal model. The approach, which uses CRISPR-Cas9 genome editing technology, offers a unique and promising strategy that could one day treat rare but debilitating motor neuron diseases in humans.

Combination Approach Shows Promise for Treating Rare, Aggressive Cancers

University of California, Los Angeles (UCLA), Health Sciences — Tue, 12 Nov 2024 11:10:27 EST

UCLA investigators have shown that that combining pembrolizumab, an immunotherapy drug, with standard chemotherapy can improve treatment outcomes for patients with small cell bladder cancer and small cell/neuroendocrine prostate cancer.

First-Ever Randomized Clinical Trial Uses Telehealth for Suicide Prevention

Ohio State University Wexner Medical Center — Tue, 12 Nov 2024 11:00:00 EST

Brief cognitive behavioral therapy for suicide prevention - when delivered remotely via video telehealth - reduces suicide attempts and suicidal ideation. The Ohio State University Wexner Medical Center and College of Medicine led the study that is published online in the journal JAMA Network Open.

Study: Antibiotics Can Cause Harm to Flu Patients

Cedars-Sinai — Tue, 12 Nov 2024 10:25:29 EST

Taking antibiotics during an influenza infection can be harmful and increases the risk of developing a bacterial pneumonia while sick with the flu, according to new research led by Cedars-Sinai.

Jeffrey Popma, MD, Joins CRF as Chief Scientific and Strategic Officer

Cardiovascular Research Foundation (CRF) — Mon, 11 Nov 2024 17:20:52 EST

The Cardiovascular Research Foundation(r) (CRF(r)) proudly announces the appointment of Dr. Jeffrey Popma as Chief Scientific and Strategic Officer. A world-renowned leader in cardiovascular research, Dr. Popma will drive forward pivotal programs and initiatives that will shape CRF's future and fuel innovation at the CRF(r) Clinical Trials Center (CTC). His leadership will be instrumental in the development of the recently launched Real-World Data and Outcomes Center, advancing CRF's commitment to impactful research. Additionally, as Program Director for New York Valves and TCT(r) (Transcatheter Cardiovascular Therapeutics(r)), CRF's flagship scientific meeting, Dr. Popma will play a key role in guiding the organization's transformative contributions to the field of cardiovascular medicine.

Deep Vein Thrombosis Affects 3% of Central Venous Catheters in NICU Patients

Children's Hospital Los Angeles — Fri, 08 Nov 2024 09:30:27 EST

Central venous catheters are frequently used in babies in neonatal intensive care units (NICUs)--providing key nutrition, fluids, and medications. But while these catheters are critical for survival, they can also be linked to risks such as deep vein thrombosis.Thromboses can lead to a host of issues, including long-term swelling of the affected limb, pulmonary embolism, longer hospital stays, and mortality.

New Device Would Help Those with Chronic Conditions Get Timely Treatment

University of Nebraska-Lincoln — Thu, 07 Nov 2024 12:15:37 EST

Husker engineer Eric Markvicka is developing a new approach for detecting acute exacerbations of chronic conditions.

Hematology, Oncology, Neuro-Oncology & Stem Cell Transplantation Updates: Fall 2024

Ann and Robert H. Lurie Children's Hospital of Chicago — Thu, 07 Nov 2024 12:00:13 EST

Lurie Children's is proud to announce the appointment of new leadership across key programs and sections within the Center for Cancer and Blood Disorders.

Hourglass-Shaped Stent Could Ease Severe Chest Pain From Microvascular Disease

Mayo Clinic — Thu, 07 Nov 2024 09:05:37 EST

A study at Mayo Clinic suggests that an hourglass-shaped stent could improve blood flow and ease severe and reoccurring chest pain in people with microvascular disease.

MSK Research Highlights, November 6, 2024

Memorial Sloan Kettering Cancer Center — Wed, 06 Nov 2024 11:35:15 EST

New MSK research marks a potential advance against RAS-driven cancers; breaks down data silos to better predict cancer outcomes with the help of artificial intelligence (AI); identifies two enzymes vital for maintaining brain health; uncovers how changes to "helper" proteins drive cancer cell survival; develops a new model for investigating lung cancer metastasis; and uses AI to improve outcome predictions in sarcoma.

Healing, Spiritual Purposes Drive Many Veterans' Use of Psychedelics

Ohio State University — Wed, 06 Nov 2024 11:05:09 EST

Most U.S. military veterans who have used psychedelics reported in a recent study that they pursued the substances for healing or spiritual exploration, and over 80% said they benefited from the experience - even those who had challenging outcomes.

Johns Hopkins Medicine Study Expands Understanding of How Fecal Microbiota Transplants May Work to Restore Gut Health

Johns Hopkins Medicine — Wed, 06 Nov 2024 10:00:53 EST

In a novel study that identified male chromosome genetic material in the intestines of female patients undergoing fecal transplants, researchers at Johns Hopkins Medicine say they have significantly expanded scientific understanding of how some of these transplants may succeed and work.

Stereotactic Radiosurgery Achieves High Rates of Tumor Control for Koos Grade I Vestibular Schwannomas

Wolters Kluwer Health: Lippincott — Wed, 06 Nov 2024 09:30:02 EST

As primary care for Koos grade I vestibular schwannomas, stereotactic radiosurgery (SRS) is superior to observation with regard to tumor control and preservation of neurologic function, according to the results of an international, multicenter retrospective study.

How Hypoxia Helps Cancer Spread

Johns Hopkins Medicine — Tue, 05 Nov 2024 11:30:21 EST

Scientists at the Johns Hopkins Kimmel Cancer Center have identified 16 genes that breast cancer cells use to survive in the bloodstream after they've escaped the low-oxygen regions of a tumor. Each is a potential therapeutic target to stop cancer recurrence, and one - MUC1 - is already in clinical trials.

Researchers Report First Published Case of a Patient with Treatment-Emergent Neuroendocrine Prostate Cancer Who Showed a Remarkable Response to an Anti-HER2 Antibody-Drug Conjugate

American College of Physicians (ACP) — Mon, 04 Nov 2024 17:00:00 EST

A new case report published in Annals of Internal Medicine describes the success of human epidermal growth factor receptor 2 (HER2) antibody-drug conjugate trastuzumab deruxtecan (T-DXd) in a patient with HER2-expressing treatment-emergent neuroendocrine prostate cancer (t-NEPC).

Lurie Children's to Develop a Novel Genomic Test for More Rapid Precision Diagnosis of Brain Tumors

Ann and Robert H. Lurie Children's Hospital of Chicago — Mon, 04 Nov 2024 10:30:57 EST

Ann & Robert H. Lurie Children's Hospital of Chicago was awarded $3.7 million through the National Cancer Institute Cancer Moonshot Scholars program to advance precision diagnosis of brain tumors in children.

National Multiple Sclerosis Society Awards $1M to Case Western Reserve University Researchers to Study New Approach to Treat the Disease

Case Western Reserve University — Mon, 04 Nov 2024 08:00:00 EST

Multiple sclerosis (MS) is a debilitating disease of the brain and spinal cord that impacts millions worldwide. In MS, the immune system mistakenly attacks the myelin sheath--a protective layer surrounding nerve cells in the nervous system. The loss of myelin, combined with ongoing inflammation, causes dysfunction and death of nerve cells, making the disability worse, such as difficulties with movement, coordination, and sensation. Treatments now focus on reducing attacks on myelin, but don't address nerve-cell damage and death. But with $1 million from the National Multiple Sclerosis Society (NMSS), a research team co-led by Paul Tesar, the Dr. Donald and Ruth Weber Goodman Professor of Innovative Therapeutics and director of the Institute for Glial Sciences, and Ben Clayton, assistant professor and founding member of the Institute for Glial Sciences, both in the Department of Genetics and Genome Sciences at the Case Western Reserve University School of Medicine, will take a different