News Curated �鶹��ý Channel: National Institute of Allergy and Infectious Diseases (NIAID)

Scientists Demonstrate Pre-clinical Proof of Concept for Next-Gen DNA Delivery Technology

Wistar Institute — Fri, 21 Mar 2025 11:05:00 EST

Wistar Institute scientists and collaborators describe a next-generation vaccination technology that combines plasmid DNA with a lipid nanoparticle delivery system.

Current Antivirals Likely Less Effective Against Severe Infection Caused by Bird Flu Virus in Cows' Milk

St. Jude Children's Research Hospital — Mon, 17 Mar 2025 19:45:43 EST

Existing antivirals may be less effective against this H5N1 bird flu strain, and prevention measures, such as avoiding raw milk consumption and reducing exposure in dairy workers, may be the most effective way to protect against the virus.

Mount Sinai Researchers Develop Method to Identify Dormant Cells That Carry HIV

Mount Sinai Health System — Thu, 13 Mar 2025 21:00:48 EST

Study findings provide a new gene pathway for potential treatment of the virus affecting millions

Increased Cancer Risk for Kidney Transplant Recipients Linked to Epstein-Barr Virus

Perelman School of Medicine at the University of Pennsylvania — Mon, 10 Feb 2025 10:00:04 EST

More than 90% of the adult population in the U.S. is or has been infected with Epstein Barr virus (EBV). EBV is a highly contagious member of the herpes virus family, best known for causing infectious mononucleosis ("mono") and for its association with several cancers and autoimmune diseases. Kidney transplant patients who've never been exposed to EBV but receive organs from a donor who carried the virus may develop a life-threatening post-transplant complication called lymphoproliferative disorder (PTLD), according to a new study from the Perelman School of Medicine at the University of Pennsylvania. An estimated 4 to 5 percent of adult kidney transplants - as many as 1200 patients per year - could be at risk of the condition, in which the body's immune system gets confused and immune cells can grow out of control and act like cancer. The findings were recently published in Annals of Internal Medicine.

Nasal COVID-19 Vaccine Based on WashU Technology to Enter U.S. Clinical Trials

Washington University in St. Louis — Wed, 05 Feb 2025 19:00:22 EST

A nasal vaccine for COVID-19 - based on technology developed at Washington University in St. Louis - is poised to enter a phase 1 clinical trial in the U.S.

As the Protein Data Bank Thrives, Its Funding is Renewed at Increased Levels

Rutgers University-New Brunswick — Tue, 14 Jan 2025 20:10:40 EST

Federal science agencies have renewed and increased funding for a world-renowned digital archive of protein structures housed by Rutgers University-New Brunswick, an open-access data resource that has enabled research in everything from agriculture to zoology and has laid the groundwork for Nobel Prize-winning discoveries.

NIH Announces Awards to Advance Tech for HIV Viral Load Detection

National Institute of Biomedical Imaging and Bioengineering — Thu, 19 Dec 2024 19:55:08 EST

NIH awarded more than $4 million in funds and support services to three diagnostic technology developers as part of the RADx Tech's Advanced Platforms for HIV Viral Load Monitoring program.

New Research Could Pave Way for Vaccine Against Deadly Wildlife Disease

Michigan State University — Tue, 19 Nov 2024 15:35:18 EST

Sean Crosson, a Professor Rudolph Hugh Endowed Chair in Michigan State University's Department of Microbiology, Genetics and Immunology, has been awarded a $2.4 million grant from the National Institutes of Health's National Institute of Allergy and Infectious Diseases to study the cause of that very disease, Brucella abortus.

Study: AI Could Transform How Hospitals Produce Quality Reports

UC San Diego Health — Mon, 21 Oct 2024 11:35:46 EST

University of California San Diego School of Medicine researchers find advanced AI could lead to easier, faster and more efficient hospital quality reporting.

Houston Methodist Prepares for Next Pandemic as Part of National NIH-Funded Consortium

Houston Methodist — Thu, 03 Oct 2024 19:05:13 EST

The question isn't if, but when, the next pandemic will hit. Research and observation have identified strong potential for the next pandemic-causing virus to come from one or more of five different virus families.

Triple Antibody Therapy Shows Promise for Long-Lasting HIV Control

Beth Israel Lahey Health — Thu, 12 Sep 2024 09:05:26 EST

In a study of 12 participants, researchers at Beth Israel Deaconess Medical Center (BIDMC) have demonstrated that a cocktail of three broadly neutralizing antibodies (bNAb) successfully suppressed virus in people living with HIV. A subset of participants also demonstrated long-term control of the virus months after antibody levels declined to low or undetectable.

T helper cells may be the key to improving annual influenza vaccines

St. Jude Children's Research Hospital — Tue, 20 Aug 2024 10:05:28 EST

The annual influenza vaccination provides updated protection against the virus but could be improved as there is large variability in its efficacy.

Long-Term Study Reaffirms Benefits of Covid-19 Vaccination for Organ Transplant Recipients

Johns Hopkins Medicine — Fri, 18 Aug 2023 12:05:42 EST

A two-year study found that spikes of post-vaccination SARS-CoV-2 viral infections (commonly known as COVID-19 breakthrough cases) remain common, yet hospitalization rates have dramatically dropped following the first wave of the virus' omicron subvariant.

Immune cells present long before infection predict flu symptoms

St. Jude Children's Research Hospital — Thu, 17 Aug 2023 12:35:01 EST

St. Jude Children's Research Hospital scientists found that immune cells present in individuals long before influenza infection predict whether the illness is symptomatic.

UTSW finds potential key to predict immunotherapy toxicity

UT Southwestern Medical Center — Mon, 14 Aug 2023 11:50:25 EST

Researchers at UT Southwestern Medical Center have identified a novel parameter of T cells that could help oncologists anticipate which patients would be most likely to develop immunotherapy toxicity. The findings, published in the Journal for ImmunoTherapy of Cancer, could lead to improved treatments for a variety of cancers.

Academic-private partnership aims to reduce toxic effects of deadly digestive bacteria

Virginia Tech — Wed, 09 Aug 2023 10:20:28 EST

The bacterium commonly referred to as C. diff is sometimes called "C-difficult" because it is so hard to treat, said Mohamed Seleem, director of the Center for One Health Research. Seleem and Nectagen Inc. have received a nearly $275,000 grant from the National Institute of Allergy and Infectious Diseases to study whether synthetic proteins developed by Nectagen can reduce the toxicity of the digestive bacteria.

Alternative cellular 'fuels' boost immunity

Van Andel Institute — Fri, 28 Jul 2023 11:05:11 EST

A metabolic by-product that is more prevalent during fasting may supercharge immune cells as they fight infection and disease, reports an early stage study by Van Andel Institute scientists and collaborators.

Study explores how often children diagnosed with flu experience serious neuropsychiatric side effects

Vanderbilt University Medical Center — Mon, 24 Jul 2023 11:40:35 EST

While the incidence of influenza-associated neuropsychiatric events in children in the United States is unknown, the controversy over the use of a common antiviral medication typically administered to treat flu in children has sparked concern among parents and medical professionals alike. The dilemma about whether the treatment causes neuropsychiatric events or if the infection itself is the culprit, led a group of pediatric researchers at Monroe Carell Jr.

ASBMB expresses concerns on proposed NIH budget cuts

American Society for Biochemistry and Molecular Biology (ASBMB) — Fri, 21 Jul 2023 10:00:10 EST

ASBMB publishes a statement expressing concerns for NIH budget cuts outlined by a House Labor HHS funding bill that could lead to lost jobs and halted research progress

New Community Partnership Model Boosts Inclusion of Participants into HIV Cure-Directed Research

Wistar Institute — Wed, 19 Jul 2023 12:05:09 EST

Scientists have long used community advisory boards to engage communities and provide feedback on studies, but this model has limitations. Now, Wistar Institute researchers are sharing how a more inclusive model for community engagement can lead to deeper insights and greater community participation in HIV research.