News Curated �鶹��ý Channel: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

Researchers Discover Genetic Locations for Increased Risk of Hidradenitis Suppurativa

University of North Carolina School of Medicine — Wed, 26 Jul 2023 15:05:10 EST

Hidradenitis suppurativa (HS) is a chronic inflammatory follicular disease which causes painful lumps to form under the skin. The lumps typically form in areas where skin rubs together - such as the armpits, groin, and under the breasts. HS can range in severity from occasional fluid-filled abscesses to widespread rope-like scarring, chronic pain, and increase of infection.

Mount Sinai Awarded Prestigious $1.3 Million Grant to Expand Research Training Program in Skin Biology

Mount Sinai Health System — Mon, 03 Apr 2023 08:50:39 EST

The Kimberly and Eric J. Waldman Department of Dermatology at the Icahn School of Medicine at Mount Sinai will expand its research training program in skin biology with support from a five-year, $1.3 million T32 grant from the National Institutes of Health (NIH) and the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS).

An extra X chromosome-linked gene may explain decreased viral infection severity in females

University of California, Los Angeles (UCLA), Health Sciences — Thu, 16 Mar 2023 19:25:22 EST

Researchers may have found why viral infections hit males more severely than females. They found that female mouse and human NK cells have an extra copy of an X chromosome-linked gene called UTX. UTX acts as an epigenetic regulator to boost NK cell anti-viral function, while repressing NK cell numbers.

Researchers uncover new cell types involved in osteoarthritis

Michigan Medicine - University of Michigan — Thu, 09 Mar 2023 14:55:39 EST

A Michigan Medicine study has identified a new potential target for treating osteoarthritis - a debilitating joint disease that affects over 31 million Americans and is a leading cause of disability worldwide.

New Study: Abatacept Therapy Offers Promising Results Treating Juvenile Dermatomyositis

George Washington University — Wed, 08 Mar 2023 12:40:35 EST

Juvenile dermatomyositis, a rare but often severe and chronic systemic autoimmune disease, includes a large number of patients who are treatment resistant, requiring long term immunosuppressive therapy. A small open-label study published in Arthritis and Rheumatology shows promise using a targeted biologic therapy called abatacept to treat such patients.

Study Finds Lower Risk of Severe Infection and Hospitalization with Belimumab Compared to Oral Immunosuppressants

American College of Rheumatology (ACR) — Tue, 08 Nov 2022 11:50:52 EST

New research presented this week at ACR Convergence 2022, the American College of Rheumatology's annual meeting, found that the biologic B-cell inhibitor belimumab was associated with a lower risk of severe infections and hospitalizations compared to nonbiologic immunosuppressants.

Holding Mycophenolate Mofetil for 10 Days or More May Improve COVID-19 Vaccine Response

American College of Rheumatology (ACR) — Tue, 08 Nov 2022 11:20:11 EST

New research presented this week at ACR Convergence 2022, the American College of Rheumatology's annual meeting, demonstrated that withholding mycophenolate mofetil for 10 days significantly increased antibody response after 2 doses of COVID-19 vaccine, without a significant increase in flares.

Study Finds AAV Characteristics and Treatments Vary Across Lifespan

American College of Rheumatology (ACR) — Tue, 08 Nov 2022 11:05:20 EST

New research presented this week at ACR Convergence 2022, the American College of Rheumatology's annual meeting, demonstrated an association between age of diagnosis and clinical characteristics and treatments in Anti-neutrophil cytoplasmic antibody-associated vasculitis patients.

Novel Study Identifies Key Molecular Players in Rheumatoid Arthritis

University of California San Diego — Mon, 24 Oct 2022 17:05:12 EST

Using a novel systems biology approach, scientists at UC San Diego School of Medicine have further parsed the cellular players and roles involved in rheumatoid arthritis, a complex disease that affects more than one million Americans in ways that have defied development of uniform treatments.

Scientists ID pathway that triggers mice to scratch when they see others do the same

Washington University in St. Louis — Tue, 04 Oct 2022 11:00:34 EST

Researchers at Washington University School of Medicine in St. Louis have identified a pathway in the brains of mice that is activated when the animals see other mice scratching, but that pathway does not run through the visual cortex.

New UCI-Led Study Reveals Characteristics of Stable Vitiligo Skin Disease

University of California, Irvine — Mon, 06 Jun 2022 16:05:00 EST

A new study, led by researchers from the University of California, Irvine, reveals the unique cell-to-cell communication networks that can perpetuate inflammation and prevent repigmentation in patients with vitiligo disease.

Neural Pathway Key to Sensation of Pleasant Touch Identified

Washington University in St. Louis — Thu, 28 Apr 2022 14:00:00 EST

Researchers from the Washington University Center for the Study of Itch and Sensory Disorders have identified a specific neuropeptide and a neural circuit that transmit pleasant touch from the skin to the brain. The findings eventually may help scientists better understand and treat disorders characterized by touch avoidance and impaired social development.

Piezo1 Possible Key to Supporting Muscle Regeneration in Duchenne Muscular Dystrophy

Perelman School of Medicine at the University of Pennsylvania — Fri, 18 Mar 2022 14:00:00 EST

Tracing the impact of a single protein, Piezo1, Penn researchers found that restoring it in muscles affected by Duchenne muscular dystrophy could improve their ability to heal efficiently

Origin of Rare Disease FOP Rooted in Muscle Regeneration Dysfunction

Perelman School of Medicine at the University of Pennsylvania — Fri, 14 Jan 2022 05:00:00 EST

A mutation in the gene that causes fibrodysplasia ossificans progressiva (FOP) doesn't just cause extra bone growth but is tied to a problem in generating new muscle tissue after injury

Mount Sinai Awarded Prestigious $4 Million Grant to Launch Skin Biology and Diseases Resource-based Center

Mount Sinai Health System — Wed, 20 Oct 2021 08:00:11 EST

The Icahn School of Medicine at Mount Sinai is establishing a Skin Biology and Diseases Resource-based Center (SBDRC), funded by a $4 million grant from the National Institutes of Health and the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS).

Drug Cocktail Reduces Aging-Associated Disc Degeneration

Thomas Jefferson University — Fri, 03 Sep 2021 05:00:00 EST

Therapies that target aging cells early pave the way to easing back pain

Rheumatoid arthritis treated with implanted cells that release drug

Washington University in St. Louis — Wed, 01 Sep 2021 14:00:00 EST

Researchers at Washington University School of Medicine in St. Louis have genetically engineered cells that, when implanted in mice, deliver a biologic drug in response to inflammation.

Penn Center for Musculoskeletal Disorders NIH Grant Renewed for $4 Million

Perelman School of Medicine at the University of Pennsylvania — Wed, 25 Aug 2021 10:35:03 EST

The United States' longest-running NIH-sponsored musculoskeletal research center will receive $4M to continue its studies of everything from ligament tears to osteoarthritis

'Fortunate Accident' May Yield Immunity Weapon Against Antibiotic-Resistant Bacteria

Johns Hopkins Medicine — Wed, 07 Jul 2021 14:30:01 EST

In what turned out to be one of the most important accidents of all time, Scottish bacteriologist Alexander Fleming returned to his laboratory after a vacation in 1928 to find a clear zone surrounding a piece of mold that had infiltrated a petri dish full of Staphylococcus aureus (S. aureus), a common skin bacterium he was growing.

What makes us sneeze?

Washington University in St. Louis — Tue, 15 Jun 2021 11:00:00 EST

What exactly triggers a sneeze? A team led by researchers at Washington University School of Medicine in St. Louis has identified, in mice, specific cells and proteins that control the sneeze reflex. Better understanding of what causes us to sneeze -- specifically how neurons behave in response to allergens and viruses -- may point to treatments capable of slowing the spread of infectious respiratory diseases.