News Curated �鶹��ý Channel: National Institute of Neurological Disorders and Stroke (NINDS)

Review strengthens evidence that repetitive head impacts can cause CTE

Boston University School of Medicine — Fri, 10 Feb 2023 19:50:49 EST

During the past 17 years, there has been a remarkable increase in scientific research concerning chronic traumatic encephalopathy (CTE) with researchers at the BU CTE Center at the forefront.

St. Jude scientists create more efficient CAR immunotherapies using a molecular anchor

St. Jude Children's Research Hospital — Thu, 02 Feb 2023 14:15:32 EST

St. Jude scientists added a small physical structure called an anchor domain to the CAR molecule. The anchor domain connects the CAR to the internal infrastructure of the immune cell. It augments and helps organize the immune synapse

Spinal Cord Injury: Can Brain and Nerve Stimulation Restore Movement?

Columbia University Irving Medical Center — Fri, 27 Jan 2023 14:05:13 EST

Even in people with complete paralysis after spinal cord injury, some nerves fibers are preserved. A Columbia physician-scientist is developing a new way to salvage those fibers and restore movement.

Special Vascular Cells Adjust Blood Flow in Brain Capillaries Based on Local Energy Needs

University of Maryland School of Medicine — Wed, 25 Jan 2023 11:35:07 EST

University of Maryland School of Medicine's researchers have discovered that a certain type of cell that sits on top of the brain's smallest blood vessels senses when their brain region needs energy. When glucose levels are low, these cells signal blood vessels to dilate, increasing the blood flow regionally and allowing more energy to fuel that part of the brain.

Does the Risk of Stroke from Common Risk Factors Change as People Age?

American Academy of Neurology (AAN) — Wed, 18 Jan 2023 16:00:00 EST

High blood pressure and diabetes are known risk factors for stroke, but now a new study shows that the amount of risk may decrease as people age. The study is published in the January 18, 2023, online issue of Neurology(r), the medical journal of the American Academy of Neurology.

Food for thought: Early Nutrition Shapes the Brain and Influences What We Like to Eat

Stony Brook University — Wed, 11 Jan 2023 14:00:00 EST

A new study by Stony Brook University researchers showed there is indeed a strong relationship between what we eat early in life and food preferences in adults. This relationship depends the effects of our early experience with food has on the brain. The work is published in Science Advances.

$11M NIH Grant Will Support Evaluation of Alzheimer's Screening Tool in Primary Care Settings

Albert Einstein College of Medicine — Thu, 08 Dec 2022 11:00:04 EST

Investigators at Albert Einstein College of Medicine, Montefiore Health System, Regenstrief Institute, and Indiana University School of Medicine have received an $11 million grant from the National Institutes of Health (NIH) to evaluate an Einstein-developed test for assessing cognitive impairment and dementia.

CHOP Researchers Discover Genetic Variant Associated with Earlier Onset Childhood Epilepsy

Children's Hospital of Philadelphia — Wed, 30 Nov 2022 14:05:26 EST

Researchers have discovered a specific genetic variant in SCN1A, the most common genetic epilepsy, that leads to an earlier onset of epilepsy, with clinical features distinct from other epilepsies. The researchers also identified a potentially effective treatment strategy.

UTSW scientists identify brain circuit that triggers rare, blood sugar-dependent epilepsy

UT Southwestern Medical Center — Wed, 16 Nov 2022 17:15:20 EST

A small group of brain cells linked in a circuit is responsible for setting off whole-brain seizures in a rare form of epilepsy affected by blood sugar levels, a study led by UT Southwestern researchers suggests. The finding, published in Science Translational Medicine, could lead to new treatments for other metabolic disorders in the brain, the authors said.

Study Highlights Importance of Long-term Management of Hypertension

Wake Forest University School of Medicine — Wed, 12 Oct 2022 11:05:38 EST

In 2015, published findings from the landmark Systolic Blood Pressure Intervention Trial (SPRINT) showed that intensive blood pressure management reduced cardiovascular disease and lowered the risk of death. In 2019, results of the SPRINT MIND trial showed that lowering blood pressure also reduced the risk of mild cognitive impairment in older adults. Now, researchers from Wake Forest University School of Medicine have shown that while intensive blood pressure control was beneficial to SPRINT participants' health during the trial, the benefits for cardiovascular mortality went away after approximately two years when protocols for blood pressure management were no longer being followed.

Scientists ID pathway that triggers mice to scratch when they see others do the same

Washington University in St. Louis — Tue, 04 Oct 2022 11:00:34 EST

Researchers at Washington University School of Medicine in St. Louis have identified a pathway in the brains of mice that is activated when the animals see other mice scratching, but that pathway does not run through the visual cortex.

High blood pressure speeds up mental decline, but does not fully explain dementia disparities

Michigan Medicine - University of Michigan — Wed, 28 Sep 2022 12:15:24 EST

High blood pressure means faster slide into signs of dementia or Alzheimer's, but does not explain the overall disparity between Hispanic/Latino people and non-Hispanic people in dementia risk.

New Grant Supports Cognitive Risk-Benefit Analysis of Playing Soccer

Albert Einstein College of Medicine — Thu, 22 Sep 2022 11:00:17 EST

Researchers at Albert Einstein College of Medicine have now received a five-year, $3.4 million grant from the National Institutes of Health (NIH) to assess the tradeoffs between soccer's aerobic brain benefits and the adverse effects from heading in a study employing neuroimaging, exercise testing, and cognitive testing.

New Study Provides Insights Into Stroke Recurrence and Death in Patients with Insulin Resistance

George Washington University — Wed, 21 Sep 2022 14:15:28 EST

In patients with post-stroke cognitive impairment, the risk factors that contribute to stroke recurrence or death in certain populations is still unknown. A better understanding of who is at risk for a stroke recurrence or death would allow clinicians to better identify, monitor and treat stroke patients at a higher risk, which could potentially prevent stroke recurrence and save lives.

Restoring movement after spinal cord injury focus of new research

Washington University in St. Louis — Tue, 06 Sep 2022 13:05:55 EST

Ismael Seanez will lead an interdisciplinary team of Washington University researchers and physicians to understand the changes in the neural circuits that may result in motor function improvements through using spinal cord stimulation.

Tufts University Scientists Identify Brain Pathway Connected to Hunger and Overeating

Tufts University — Thu, 25 Aug 2022 13:55:24 EST

Scientists at Tufts University have discovered a pathway through which communications are regulated in the brain, and a misfire in the messaging can result in overeating, slower burning of calories, and other metabolic problems linked to obesity.

Penn State awarded $1.6M to study if COVID-19 contributes to cognitive decline

Penn State College of Medicine — Thu, 25 Aug 2022 09:45:51 EST

Penn State College of Medicine received a $1.6 million grant from the National Institutes of Health will support research into whether COVID-19 contributes to the development of cognitive decline.

FSU Team Makes Discovery Advancing Epilepsy Research

Florida State University — Mon, 18 Jul 2022 15:20:24 EST

A team of Florida State University College of Medicine researchers has found a link between a specific protein in the brain and increased vulnerability to neurodegeneration for individuals with temporal lobe epilepsy (TLE).

Organoids Reveal Similarities Between Myotonic Dystrophy Type 1 & Rett Syndrome

UC San Diego Health — Wed, 29 Jun 2022 15:05:56 EST

Using brain organoids, UC San Diego researchers discover mutational commonalities between muscular dystrophy type 1 and Rett syndrome, suggesting the potential of a similar treatment for both.

Dynamic Cells Linked to Brain Tumor Growth and Recurrence

Michigan Medicine - University of Michigan — Tue, 28 Jun 2022 15:05:29 EST

Tumors are made up of many types of cells, both cancerous and benign. The specific complexity of the cells inside brain tumors has been a trademark of the disease, one that makes treatment extremely difficult. While scientists have long known about the variety of cells within a brain tumor, the ways these tumors grow has relied on the understanding that the cells are static, unmoving and relatively fixed.