News Feature Channel: Drug Resistance

New CRISPR-Based Diagnostic Test Detects Pathogens in Blood Without Amplification

University Of Illinois Grainger College Of Engineering — Fri, 14 Mar 2025 20:50:39 EST

UC Irvine Scientists Invent New Drug Candidates to Treat Antibiotic-Resistant Bacteria

University of California, Irvine — Mon, 24 Feb 2025 19:05:39 EST

Irvine, Calif., Feb. 24, 2025 -- There's an arms race in medicine - scientists design drugs to treat lethal bacterial infections, but bacteria can evolve defenses to those drugs, sending the researchers back to square one. In the Journal of the American Chemical Society, a University of California, Irvine-led team describes the development of a drug candidate that can stop bacteria before they have a chance to cause harm.

Why Anti-TNF Drugs Don't Work for Some Kids with Crohn's Disease

Michigan Medicine - University of Michigan — Wed, 12 Feb 2025 21:55:58 EST

Research from Michigan Medicine has investigated possible genetic factors for drug efficacy for children with Crohn's disease. In this latest study, HLA DQA1*05 positive children just taking anti-TNF mediation had the highest rate of drug failure.

Diabetes Can Drive the Evolution of Antibiotic Resistance

University of North Carolina School of Medicine — Wed, 12 Feb 2025 14:00:00 EST

Researchers at the UNC School of Medicine have proven that antibiotic-resistant strains of a harmful bacteria thrive in a diabetic infection environment.

Tackling the Threat of Drug-Resistant E. Coli in China

Chinese Academy of Sciences — Mon, 10 Feb 2025 09:15:49 EST

A comprehensive seven-year study across 20 Chinese provinces has revealed a concerning rise in antimicrobial resistance (AMR) among diarrheagenic Escherichia coli (E. coli), a major foodborne pathogen. Analyzing 9,068 isolates from sporadic human diarrhea cases, the research paints a troubling picture: the majority of isolates are resistant to at least one antimicrobial agent, with many demonstrating multidrug resistance. These findings are critical for shaping clinical antibiotic treatment strategies and prioritizing efforts to curb the spread of resistance.

The Wistar Institute Scientists Discover New Weapon to Fight Treatment-Resistant Melanoma

Wistar Institute — Wed, 05 Feb 2025 19:50:57 EST

The Wistar Institute scientists have identified a new strategy for attacking treatment-resistant melanoma: inhibiting the gene S6K2.

Study Finds Three New Safe, Effective Ways To Treat Drug-Resistant Tuberculosis

Harvard Medical School — Wed, 29 Jan 2025 17:00:00 EST

* Study finds three new safe and effective drug regimens to fight multidrug-resistant TB * The treatments, which include recently discovered TB drugs, give new options for shorter, personalized treatment and are cleared for use for more people than ever

Researchers Testing Antibody to Treat Drug-Resistant Bacteria

West Virginia University — Tue, 28 Jan 2025 09:45:03 EST

West Virginia University microbiologists have identified an antibody that can kill one of the most drug-resistant bacteria. Now, supported by a $3.5 million grant from the National Institute of Allergy and Infectious Diseases, they want to determine whether it can be combined with other antibiotics to produce a potent treatment against infection.

Drug Candidate Eliminates Breast Cancer Tumors in Mice in a Single Dose

American Chemical Society (ACS) — Wed, 22 Jan 2025 08:00:00 EST

Researchers reporting in ACS Central Science have created a novel treatment that eliminated small breast tumors and significantly shrank large tumors in mice in a single dose, without problematic side effects.

HealthTrackRx Expands Operations with New Campus at UPS Healthcare Labport Facility in Louisville, Enhancing Capabilities for Faster, More Affordable Diagnostic Testing

HealthTrackRx — Thu, 16 Jan 2025 09:10:13 EST

HealthTrackRx, the nation's premier molecular diagnostic laboratory for infectious diseases, today announced the opening of its newest campus at the state-of-the-art UPS Healthcare Labport facility in Louisville.

Overcoming Resistance: McMaster Researchers Find New Utility for Old Antibiotics

McMaster University — Mon, 06 Jan 2025 16:55:11 EST

Researchers at McMaster University have discovered a critical vulnerability in drug-resistant bacteria: zinc -- or a lack thereof.

The FC428 Clone: Tracking Global Transmission of Drug-Resistant Gonorrhea

Chinese Academy of Sciences — Mon, 30 Dec 2024 06:30:58 EST

The emergence of Neisseria gonorrhoeae strains resistant to ceftriaxone, the last reliable treatment, poses significant public health threats. The global spread of the FC428 clone, carrying penA allele 60.001, is of particular concern due to its association with high-level ceftriaxone resistance and frequent treatment failures.

A Public Health Emergency Is Waiting at the Bottom of the Antibiotic Resistance Cliff

Northern Arizona University — Thu, 26 Dec 2024 05:00:00 EST

New research led by Northern Arizona University showed that it's not if, but when we will see pan-resistance.

Battling Breast Cancer: New Insights Into Angiogenesis and Drug Resistance

Chinese Academy of Sciences — Wed, 11 Dec 2024 07:05:14 EST

Breast cancer's resistance to treatment is a major hurdle in improving patient outcomes. A recent study explores how tumor angiogenesis--the formation of abnormal blood vessels in tumors--plays a pivotal role in fostering drug resistance. The research highlights how these blood vessels hinder drug delivery and create a hostile tumor environment, reducing the effectiveness of therapies. It also investigates the potential of anti-angiogenic treatments to normalize these vessels, enhancing drug efficacy and offering new hope for patients.

A New Approach to Predicting Malaria Drug Resistance

University of California San Diego — Thu, 28 Nov 2024 17:00:00 EST

Researchers at UC San Diego analyzed the genomes of hundreds of malaria parasites to determine which genetic variants are most likely to confer drug resistance.

For People Living with HIV/AIDS, TB is Still the Leading Cause of Death

American Thoracic Society (ATS) — Wed, 27 Nov 2024 10:00:54 EST

The latest World Health Organization's Global Tuberculosis Report released in November 2024 painted a sobering picture; approximately 8.2 million people were newly diagnosed with TB in 2023, the highest number since the organization began global TB monitoring in 1995. TB is the leading cause of death among those with HIV /AIDS worldwide. According to the WHO, in 2023, 161,000 people died of HIV-associated TB.

Detroit Health Professionals Urge the Community to Act and Address the Dangers of Antimicrobial Resistance

Wayne State University Division of Research — Fri, 22 Nov 2024 14:35:48 EST

Wayne State University's Center for Emerging and Infectious Diseases (CEID) is launching its participation in World AMR Awareness Week with an urgent message: the growing threat of antimicrobial resistance requires immediate community action, so it is critical to educate, advocate, and act now.

Un antibiotico innovador para bacterias resistentes a los farmacos

American Chemical Society (ACS) — Wed, 20 Nov 2024 11:55:52 EST

Sobre la base de trabajos anteriores, los investigadores de ACS Infectious Diseases han demostrado un posible tratamiento antibacteriano a partir de una darobactina modificada, un compuesto originario de una bacteria. El equipo informa de pruebas de concepto en animales con infecciones causadas por bacterias, entre ellas, E. coli, conocidas por desarrollar farmacorresistencia.

An Innovative Antibiotic for Drug-Resistant Bacteria

American Chemical Society (ACS) — Wed, 20 Nov 2024 08:00:00 EST

Building on previous work, researchers in ACS Infectious Diseases have demonstrated a potential antibacterial treatment from a modified darobactin, a compound originally from a bacterium. The team reports proof-of-concept animal trials on infections caused by bacteria, including E. coli, that are known to develop drug resistance.

Zymo Research Leads the Way in Wastewater Innovation as Key Sponsor of the Microbes in Wastewater Symposium 2025

Zymo Research Corp — Mon, 18 Nov 2024 08:40:11 EST

Zymo Research Corporation, a global leader in innovative life science solutions, is proud to sponsor the Microbes in Wastewater: Antibiotic Resistance, Public Health, and Climate Change Symposium taking place January 16-17, 2025, in Newport Beach, California. This pivotal event will convene top researchers, industry experts, and public health professionals to explore the latest advancements in wastewater surveillance and its critical impact on public health, antibiotic resistance, and environmental sustainability.