Latest news from World Journal of Stem Cells on News en-us Copyright 2025 News 115 31 / /images/newswise-logo-rss.gif /articles/asthma-and-stem-cell-therapy/?sc=rsin /articles/asthma-and-stem-cell-therapy/?sc=rsin Wed, 26 Feb 2025 12:00:49 EST The global incidence of asthma, a leading respiratory disorder affecting more than 235 million people, has dramatically increased in recent years. Characterized by chronic airway inflammation and an imbalanced response to airborne irritants World Journal of Stem Cells /articles/fetal-mice-dermal-mesenchymal-stem-cells-promote-wound-healing-by-inducing-m2-type-macrophage-polarization/?sc=rsin /articles/fetal-mice-dermal-mesenchymal-stem-cells-promote-wound-healing-by-inducing-m2-type-macrophage-polarization/?sc=rsin Wed, 26 Feb 2025 12:00:45 EST BACKGROUNDMesenchymal stem cells, found in various tissues, possess significant healing and immunomodulatory properties, influencing macrophage polarization, which is essential for wound repair. However, chronic wounds present significant t World Journal of Stem Cells /articles/wdr36-inhibits-the-osteogenic-differentiation-and-migration-of-periodontal-ligament-stem-cells/?sc=rsin /articles/wdr36-inhibits-the-osteogenic-differentiation-and-migration-of-periodontal-ligament-stem-cells/?sc=rsin Wed, 26 Feb 2025 12:00:41 EST BACKGROUNDPeriodontitis is an inflammatory disease caused by the host's immune response and various interactions between pathogens, which lead to the loss of connective tissue and bone. In recent years, mesenchymal stem cell (SC) transpla World Journal of Stem Cells /articles/effects-of-macrophages-on-the-osteogenic-differentiation-of-adipose-tissue-derived-stem-cells-in-two-dimensional-and-three-dimensional-cocultures/?sc=rsin /articles/effects-of-macrophages-on-the-osteogenic-differentiation-of-adipose-tissue-derived-stem-cells-in-two-dimensional-and-three-dimensional-cocultures/?sc=rsin Wed, 26 Feb 2025 12:00:39 EST BACKGROUNDFracture is one of the most pervasive injuries in the musculoskeletal system, and there is a complex interaction between macrophages and adipose tissue-derived stem cells (ADSCs) in fracture healing. However, two-dimensional (2D) World Journal of Stem Cells /articles/impact-of-mir-214-5p-and-mir-21-5p-from-hypoxic-endometrial-exosomes-on-human-umbilical-cord-mesenchymal-stem-cell-function/?sc=rsin /articles/impact-of-mir-214-5p-and-mir-21-5p-from-hypoxic-endometrial-exosomes-on-human-umbilical-cord-mesenchymal-stem-cell-function/?sc=rsin Wed, 26 Feb 2025 12:00:36 EST Exosomes derived from hypoxic endometrial epithelial cells are pivotal in cellular communication and tissue repair, offering new perspectives on reproductive health. This manuscript highlights the study by Zhang et al, which investigates th World Journal of Stem Cells /articles/induced-pluripotent-stem-cell-derived-mesenchymal-stem-cells-for-modeling-and-treating-metabolic-associated-fatty-liver-disease-and-metabolic-associated-steatohepatitis-challenges-and-opportunities/?sc=rsin /articles/induced-pluripotent-stem-cell-derived-mesenchymal-stem-cells-for-modeling-and-treating-metabolic-associated-fatty-liver-disease-and-metabolic-associated-steatohepatitis-challenges-and-opportunities/?sc=rsin Wed, 26 Feb 2025 12:00:34 EST The potential of induced pluripotent stem cells (iPSCs) for modeling and treating metabolic associated fatty liver disease (MAFLD) and metabolic associated steatohepatitis (MASH) is emerging. MAFLD is a growing global health concern, curren World Journal of Stem Cells /articles/perspectives-on-schwann-like-cells-derived-from-bone-marrow-mesenchymal-stem-cells-advancing-peripheral-nerve-injury-therapies/?sc=rsin /articles/perspectives-on-schwann-like-cells-derived-from-bone-marrow-mesenchymal-stem-cells-advancing-peripheral-nerve-injury-therapies/?sc=rsin Wed, 26 Feb 2025 12:00:26 EST Peripheral nerve injuries are clinical conditions that often result in functional deficits, compromising patient quality of life. Given the relevance of these injuries, new treatment strategies are constantly being investigated. Although me World Journal of Stem Cells /articles/stem-cell-therapy-a-promising-therapeutic-approach-for-skeletal-muscle-atrophy/?sc=rsin /articles/stem-cell-therapy-a-promising-therapeutic-approach-for-skeletal-muscle-atrophy/?sc=rsin Wed, 26 Feb 2025 12:00:24 EST Skeletal muscle atrophy results from disruptions in the growth and metabolism of striated muscle, leading to a reduction or loss of muscle fibers. This condition not only significantly impacts patients' quality of life but also imposes su World Journal of Stem Cells /articles/effect-of-adipose-derived-stem-cells-exosomes-cross-linked-chitosan-glycerophosphate-thermosensitive-hydrogel-on-deep-burn-wounds/?sc=rsin /articles/effect-of-adipose-derived-stem-cells-exosomes-cross-linked-chitosan-glycerophosphate-thermosensitive-hydrogel-on-deep-burn-wounds/?sc=rsin Wed, 26 Feb 2025 12:00:08 EST BACKGROUNDBurn wound management is challenging, and while mesenchymal stem cell-derived exosomes show therapeutic potential, optimal delivery methods are unclear. AIMTo study chitosan (CS)-αβ-glycerophosphate (CS-αβ-GP) hydrogel crossl World Journal of Stem Cells /articles/effect-of-tandem-autologous-stem-cell-transplantation-on-survival-in-pediatric-patients-with-high-risk-solid-tumors-in-south-china/?sc=rsin /articles/effect-of-tandem-autologous-stem-cell-transplantation-on-survival-in-pediatric-patients-with-high-risk-solid-tumors-in-south-china/?sc=rsin Wed, 26 Feb 2025 12:00:05 EST BACKGROUNDDespite advances in treatment, the prognosis for patients with high-risk pediatric solid tumors remains dismal. Tandem autologous stem cell transplantation (ASCT) offers promise for improving outcomes in these patients. This study World Journal of Stem Cells /articles/exosomal-mir-203-from-bone-marrow-stem-cells-targets-the-socs3-nf-b-pathway-to-regulate-neuroinflammation-in-temporal-lobe-epilepsy/?sc=rsin /articles/exosomal-mir-203-from-bone-marrow-stem-cells-targets-the-socs3-nf-b-pathway-to-regulate-neuroinflammation-in-temporal-lobe-epilepsy/?sc=rsin Wed, 26 Feb 2025 12:00:03 EST BACKGROUNDEpilepsy is a prevalent chronic neurological disorder affecting 50 million individuals globally, with temporal lobe epilepsy (TLE) being the most common form. Despite advances in antiepileptic drug development, over 30% of patient World Journal of Stem Cells /articles/nicotinamide-adenine-dinucleotide-rejuvenates-septic-bone-marrow-mesenchymal-stem-cells/?sc=rsin /articles/nicotinamide-adenine-dinucleotide-rejuvenates-septic-bone-marrow-mesenchymal-stem-cells/?sc=rsin Wed, 26 Feb 2025 12:00:00 EST BACKGROUNDSepsis is a severe illness characterized by systemic and multiorgan reactive responses and damage. However, the impact of sepsis on the bone marrow, particularly on bone marrow mesenchymal stem cells (BMSCs), is less reported. BMS World Journal of Stem Cells /articles/microvesicles-derived-from-mesenchymal-stem-cells-a-promising-therapeutic-strategy-for-acute-respiratory-distress-syndrome-related-pulmonary-fibrosis5/?sc=rsin /articles/microvesicles-derived-from-mesenchymal-stem-cells-a-promising-therapeutic-strategy-for-acute-respiratory-distress-syndrome-related-pulmonary-fibrosis5/?sc=rsin Mon, 27 Jan 2025 04:50:37 EST Pulmonary fibrosis significantly contributes to the pathogenesis of acute respiratory distress syndrome (ARDS), markedly increasing patient mortality. Despite the established anti-fibrotic effects of mesenchymal stem cells (MSCs), numerous World Journal of Stem Cells /articles/bone-marrow-mesenchymal-stem-cells-promote-uterine-healing-by-activating-the-pi3k-akt-pathway-and-modulating-inflammation-in-rat-models/?sc=rsin /articles/bone-marrow-mesenchymal-stem-cells-promote-uterine-healing-by-activating-the-pi3k-akt-pathway-and-modulating-inflammation-in-rat-models/?sc=rsin Sun, 26 Jan 2025 12:00:49 EST BACKGROUNDUterine injury can cause uterine scarring, leading to a series of complications that threaten women's health. Uterine healing is a complex process, and there are currently no effective treatments. Although our previous studies h World Journal of Stem Cells /articles/extended-protective-effects-of-three-dimensional-cultured-human-mesenchymal-stromal-cells-in-a-neuroinflammation-model/?sc=rsin /articles/extended-protective-effects-of-three-dimensional-cultured-human-mesenchymal-stromal-cells-in-a-neuroinflammation-model/?sc=rsin Sun, 26 Jan 2025 12:00:43 EST BACKGROUNDHuman mesenchymal stromal cells (MSCs) possess regenerative potential due to pluripotency and paracrine functions. However, their stemness and immunomodulatory capabilities are sub-optimal in conventional two-dimensional (2D) cult World Journal of Stem Cells /articles/bridging-bioengineering-and-nanotechnology-bone-marrow-derived-mesenchymal-stem-cell-exosome-solutions-for-peripheral-nerve-injury/?sc=rsin /articles/bridging-bioengineering-and-nanotechnology-bone-marrow-derived-mesenchymal-stem-cell-exosome-solutions-for-peripheral-nerve-injury/?sc=rsin Sun, 26 Jan 2025 12:00:41 EST Peripheral nerve injury (PNI) is a common disease that is difficult to nerve regeneration with current therapies. Fortunately, Zou et al demonstrated the role and mechanism of bone marrow derived mesenchymal stem cells (BMSCs) in promoting World Journal of Stem Cells /articles/protective-activity-of-adipose-derived-stem-cell-extracellular-vesicles-in-ischemia-and-or-reperfusion/?sc=rsin /articles/protective-activity-of-adipose-derived-stem-cell-extracellular-vesicles-in-ischemia-and-or-reperfusion/?sc=rsin Sun, 26 Jan 2025 12:00:29 EST Increasing evidence of the significant clinical value of protection against ischemia/reperfusion injury has contributed to the realization of the independent importance of this approach in improving prognosis and reducing cardiovascular mor World Journal of Stem Cells /articles/melatonin-regulation-and-the-function-of-the-periodontal-ligament-future-perspective-and-challenges/?sc=rsin /articles/melatonin-regulation-and-the-function-of-the-periodontal-ligament-future-perspective-and-challenges/?sc=rsin Sun, 26 Jan 2025 12:00:18 EST The present article reviews the emerging role of melatonin (MT) and the Hippo-Yes-associated protein signaling pathway in periodontal regeneration, highlighting their potential to delay the aging process of periodontal ligament stem cells ( World Journal of Stem Cells /articles/advances-in-human-umbilical-cord-mesenchymal-stem-cells-derived-extracellular-vesicles-and-biomaterial-assemblies-for-endometrial-injury-treatment/?sc=rsin /articles/advances-in-human-umbilical-cord-mesenchymal-stem-cells-derived-extracellular-vesicles-and-biomaterial-assemblies-for-endometrial-injury-treatment/?sc=rsin Sun, 26 Jan 2025 12:00:13 EST Endometrial injury caused by repeated uterine procedures, infections, inflammation, or uterine artery dysfunction can deplete endometrial stem/progenitor cells and impair regeneration, thereby diminishing endometrial receptivity and evident World Journal of Stem Cells /articles/stromal-vascular-fraction-mechanisms-and-application-in-reproductive-disorders/?sc=rsin /articles/stromal-vascular-fraction-mechanisms-and-application-in-reproductive-disorders/?sc=rsin Sun, 26 Jan 2025 12:00:04 EST Stromal vascular fraction (SVF) is a complex mixture derived from adipose tissue, consisting of a variety of cells. Due to its potential for tissue repair, immunomodulation, and support of angiogenesis, SVF represents a promising frontier i World Journal of Stem Cells