Latest news from Stem Cell Reports on News en-us Copyright 2024 News 115 31 / /images/newswise-logo-rss.gif /articles/investigating-the-feasibility-and-ethical-implications-of-phenotypic-screening-using-nbsp-stem-cell-derived-tissue-models-to-detect-and-manage-disease/?sc=rsin /articles/investigating-the-feasibility-and-ethical-implications-of-phenotypic-screening-using-nbsp-stem-cell-derived-tissue-models-to-detect-and-manage-disease/?sc=rsin Mon, 02 May 2022 08:00:42 EST Stem-cell-derived tissue models generated from sick people are being used to understand human development and disease, drug development, and drug screening. However, it is possible to detect disease phenotypes before a patient ... Stem Cell Reports /articles/auxilin-regulates-intestinal-nbsp-stem-nbsp-cell-nbsp-proliferation-through-egfr/?sc=rsin /articles/auxilin-regulates-intestinal-nbsp-stem-nbsp-cell-nbsp-proliferation-through-egfr/?sc=rsin Fri, 22 Apr 2022 04:00:53 EST ... Importantly, we demonstrate that Aux interacts with EGFR and safeguards the activation of EGFR to maintain a proper stem  cell proliferation rate. Thus, our data uncover the underlying mechanism of Aux in stem  cell proliferation control and ... Stem Cell Reports /articles/substance-p-neurokinin-1-receptor-pathway-blockade-ameliorates-limbal-nbsp-stem-cell-nbsp-deficiency-by-modulating-mtor-pathway-and-preventing-cell-senescence/?sc=rsin /articles/substance-p-neurokinin-1-receptor-pathway-blockade-ameliorates-limbal-nbsp-stem-cell-nbsp-deficiency-by-modulating-mtor-pathway-and-preventing-cell-senescence/?sc=rsin Thu, 31 Mar 2022 04:00:17 EST ... Autologous limbal stem cell transplantation is highly successful, but impossible in cases of complete bilateral stem cell deficiency. In these ... We found that a very low amount of stem cell-like cells remained 4 weeks after the stem cell deficiency model ... Stem Cell Reports /articles/nk-cell-content-does-not-seem-to-influence-engraftment-in-ex-vivo-t-cell-depleted-haploidentical-nbsp-stem-cell-nbsp-transplantation/?sc=rsin /articles/nk-cell-content-does-not-seem-to-influence-engraftment-in-ex-vivo-t-cell-depleted-haploidentical-nbsp-stem-cell-nbsp-transplantation/?sc=rsin Tue, 15 Mar 2022 09:00:37 EST NK cell content does not seem to influence engraftment in ex vivo T cell depleted haploidentical stem cell tra ... usefulness of NK cellderived IFNg inhibition to favor engraftment in allogeneic hematopoietic stem cell transplantation (HSCT) ... Stem Cell Reports /articles/leveraging-interacting-signaling-pathways-to-robustly-improve-the-quality-and-yield-of-human-pluripotent-nbsp-stem-cell-derived-hepatoblasts-and-hepatocytes/?sc=rsin /articles/leveraging-interacting-signaling-pathways-to-robustly-improve-the-quality-and-yield-of-human-pluripotent-nbsp-stem-cell-derived-hepatoblasts-and-hepatocytes/?sc=rsin Mon, 07 Feb 2022 03:00:25 EST Pluripotent stem cell (PSC)-derived hepatocyte-like cells (HLCs) have shown great potential as an alternative to primary human hepatocytes (PHHs) for in vitro modeling. Several differentiation protocols have been described to direct PSCs toward the ... Stem Cell Reports /articles/reaching-into-the-toolbox-nbsp-stem-cell-nbsp-models-to-study-neuropsychiatric-disorders/?sc=rsin /articles/reaching-into-the-toolbox-nbsp-stem-cell-nbsp-models-to-study-neuropsychiatric-disorders/?sc=rsin Mon, 24 Jan 2022 08:55:47 EST ... This review provides an overview of stem cell-based disease models in neuropsychiatry and considers the advantages and challenges surrounding the contributions ... Summary of the key elements and challenges for each stem-cell-based ... Stem Cell Reports /articles/restoration-of-hippocampal-neural-precursor-function-by-ablation-of-senescent-cells-in-the-aging-nbsp-stem-cell-nbsp-niche/?sc=rsin /articles/restoration-of-hippocampal-neural-precursor-function-by-ablation-of-senescent-cells-in-the-aging-nbsp-stem-cell-nbsp-niche/?sc=rsin Mon, 24 Jan 2022 08:55:01 EST ... ) to ask if this is because senescent cells in stem cell niches impair precursor-mediated tissue maintenance. We demonstrate an aging-dependent accumulation of senescent cells, largely senescent NPCs, within the hippocampal stem cell niche ... Stem Cell Reports /articles/4d-imaging-analysis-of-the-aging-mouse-neural-nbsp-stem-cell-nbsp-niche-reveals-a-dramatic-loss-of-progenitor-cell-dynamism-regulated-by-the-rho-rock-pathway/?sc=rsin /articles/4d-imaging-analysis-of-the-aging-mouse-neural-nbsp-stem-cell-nbsp-niche-reveals-a-dramatic-loss-of-progenitor-cell-dynamism-regulated-by-the-rho-rock-pathway/?sc=rsin Mon, 17 Jan 2022 08:55:24 EST Stem Cell Reports /articles/cell-position-within-human-pluripotent-nbsp-stem-cell-nbsp-colonies-determines-apical-specialization-via-an-actin-cytoskeleton-based-mechanism/?sc=rsin /articles/cell-position-within-human-pluripotent-nbsp-stem-cell-nbsp-colonies-determines-apical-specialization-via-an-actin-cytoskeleton-based-mechanism/?sc=rsin Tue, 21 Dec 2021 02:00:28 EST Human pluripotent stem cells (hPSCs) grow as colonies with epithelial-like features including cell polarity and position-dependent features that contribute to symmetry breaking during development. Our study provides evidence that hPSC colonies ... Stem Cell Reports