Latest news from Science Advances on News en-us Copyright 2024 News 115 31 / /images/newswise-logo-rss.gif /articles/single-metal-organic-framework-ndash-embedded-nanopit-arrays-a-new-way-to-control-neural-nbsp-stem-cell-nbsp-differentiation/?sc=rsin /articles/single-metal-organic-framework-ndash-embedded-nanopit-arrays-a-new-way-to-control-neural-nbsp-stem-cell-nbsp-differentiation/?sc=rsin Mon, 25 Apr 2022 04:00:22 EST ... stem cell sources and differentiation lineages and is therefore useful for various stem cell-... cells and extracellular matrix components, guiding stem cell fates ex vivo is generally initiated ... ultimately negatively affects the guiding efficiency of the ... Science Advances /articles/egr1-is-a-3d-matrix-ndash-specific-mediator-of-mechanosensitive-nbsp-stem-nbsp-cell-nbsp-lineage-commitment/?sc=rsin /articles/egr1-is-a-3d-matrix-ndash-specific-mediator-of-mechanosensitive-nbsp-stem-nbsp-cell-nbsp-lineage-commitment/?sc=rsin Fri, 22 Apr 2022 04:00:59 EST ... stem  cell commitment, the field's mechanistic understanding of this phenomenon largely derives from simplified two-dimensional (2D) culture substrates. Here, we found a 3D matrix-specific mechanoresponsive mechanism for neural stem  cell (NSC ... Science Advances /articles/targeted-damid-in-c-elegans-reveals-a-direct-role-for-lin-22-and-nhr-25-in-antagonizing-the-epidermal-nbsp-stem-cell-nbsp-fate/?sc=rsin /articles/targeted-damid-in-c-elegans-reveals-a-direct-role-for-lin-22-and-nhr-25-in-antagonizing-the-epidermal-nbsp-stem-cell-nbsp-fate/?sc=rsin Tue, 08 Feb 2022 11:00:44 EST ... We report a direct role for NHR-25 in promoting cell differentiation via repressing the expression of stem cell-promoting GATA factors. Our results expand our understanding of the epidermal gene network and highlight the potential of TaDa to ... Science Advances /articles/o-linked-alpha-2-3-sialylation-defines-nbsp-stem-cell-nbsp-populations-in-breast-cancer/?sc=rsin /articles/o-linked-alpha-2-3-sialylation-defines-nbsp-stem-cell-nbsp-populations-in-breast-cancer/?sc=rsin Tue, 11 Jan 2022 01:00:18 EST We pursued the hypothesis that specific glycans can be used to distinguish breast cancer stem cells (CSCs) and influence their function. Comparison of CSCs and non- CSCs from multiple breast cancer models revealed that CSCs are distinguished by ... Science Advances /articles/single-cell-architecture-and-functional-requirement-of-alternative-splicing-during-hematopoietic-nbsp-stem-cell-nbsp-formation/?sc=rsin /articles/single-cell-architecture-and-functional-requirement-of-alternative-splicing-during-hematopoietic-nbsp-stem-cell-nbsp-formation/?sc=rsin Mon, 10 Jan 2022 08:55:46 EST Single-cell transcriptional profiling has rapidly advanced our understanding of the embryonic hematopoiesis; however, whether and what role RNA alternative splicing (AS) plays remains an enigma. This is important for understanding the mechanisms ... Science Advances