Latest news from Science Translational Medicine on News en-us Copyright 2024 News 115 31 / /images/newswise-logo-rss.gif /articles/operational-tolerance-after-hematopoietic-nbsp-stem-cell-nbsp-transplantation-is-characterized-by-distinct-transcriptional-phenotypic-and-metabolic-signatures/?sc=rsin /articles/operational-tolerance-after-hematopoietic-nbsp-stem-cell-nbsp-transplantation-is-characterized-by-distinct-transcriptional-phenotypic-and-metabolic-signatures/?sc=rsin Wed, 02 Mar 2022 08:00:17 EST ... The mechanisms underlying operational tolerance after hematopoietic stem cell transplantation in humans are poorly understood. We studied two independent cohorts of patients who underwent allogeneic hematopoietic stem cell ... Science Translational Medicine /articles/loss-of-mir-31-5p-drives-hematopoietic-nbsp-stem-cell-nbsp-malignant-transformation-and-restoration-eliminates-leukemia-stem-cells-in-mice/?sc=rsin /articles/loss-of-mir-31-5p-drives-hematopoietic-nbsp-stem-cell-nbsp-malignant-transformation-and-restoration-eliminates-leukemia-stem-cells-in-mice/?sc=rsin Fri, 04 Feb 2022 12:00:53 EST Leukemia stem cells (LSCs) propagate leukemia and are responsible for the high frequency of relapse of treated patients. The ability to target LSCs remains elusive, indicating a need to understand the underlying mechanism of LSC formation. Here ... Science Translational Medicine