Latest news from Journal of Experimental & Clinical Cancer Research on News en-us Copyright 2024 News 115 31 / /images/newswise-logo-rss.gif /articles/chloride-intracellular-channel-1-activity-is-not-required-for-glioblastoma-development-but-its-inhibition-dictates-glioma-stem-cell-responsivity-to-novel-biguanide-derivatives/?sc=rsin /articles/chloride-intracellular-channel-1-activity-is-not-required-for-glioblastoma-development-but-its-inhibition-dictates-glioma-stem-cell-responsivity-to-novel-biguanide-derivatives/?sc=rsin Mon, 14 Feb 2022 08:00:27 EST Chloride intracellular channel-1 (CLIC1) activity controls glioblastoma proliferation. Metformin exerts antitumor effects in glioblastoma stem cells (GSCs) inhibiting CLIC1 activity, but its low potency hampers its translation in clinical settings. We ... Journal of Experimental & Clinical Cancer Research