Latest news from Children's Hospital Los Angeles Saban Research Institute on News en-us Copyright 2024 News 115 31 / /images/newswise-logo-rss.gif /articles/immune-system-activation-in-pregnant-women-can-shape-brain-development-in-their-babies2/?sc=rsin /articles/immune-system-activation-in-pregnant-women-can-shape-brain-development-in-their-babies2/?sc=rsin Tue, 27 Feb 2018 18:05:54 EST A study in the Journal of Neuroscience reveals that activation of a pregnant mother's immune system can affect her baby's brain development. Researchers at CHLA, found that short- and long-term brain functioning can be influenced by immune system activity during the third trimester of gestation. Children's Hospital Los Angeles Saban Research Institute /articles/new-cellular-approach-found-to-control-progression-of-chronic-kidney-disease-/?sc=rsin /articles/new-cellular-approach-found-to-control-progression-of-chronic-kidney-disease-/?sc=rsin Thu, 14 Dec 2017 17:05:37 EST Researchers have demonstrated for the first time that extracellular vesicles - tiny protein-filled structures - isolated from amniotic fluid stem cells (AFSCs) can be used to effectively slow the progression of kidney damage in mice with a type of chronic kidney disease. Children's Hospital Los Angeles Saban Research Institute /articles/study-to-examine-how-tumor-necrosis-factor-works-to-reduce-intestinal-inflammation/?sc=rsin /articles/study-to-examine-how-tumor-necrosis-factor-works-to-reduce-intestinal-inflammation/?sc=rsin Mon, 20 Nov 2017 11:05:14 EST An investigator at Children's Hospital Los Angeles, has been awarded $1.5 million by the National Institute of Diabetes and Digestive and Kidney Diseases of the NIH for the study of tumor necrosis factor (TNF) and its role in inflammatory bowel disease (IBD). Children's Hospital Los Angeles Saban Research Institute /articles/chla-is-awarded-more-than-1-million-from-st-baldrick-s-foundation-to-fund-cancer-research/?sc=rsin /articles/chla-is-awarded-more-than-1-million-from-st-baldrick-s-foundation-to-fund-cancer-research/?sc=rsin Mon, 13 Nov 2017 16:05:50 EST Three physician-researchers at Children's Hospital Los Angeles have been awarded more than $1 million in grants from the St. Baldrick's Foundation to support research efforts spanning both neuroblastoma and acute lymphoblastic leukemia - two of the most aggressive childhood cancers. Children's Hospital Los Angeles Saban Research Institute /articles/brain-imaging-research-in-premature-babies-to-identify-biomarkers-linked-to-cognitive-and-behavioral-disorders/?sc=rsin /articles/brain-imaging-research-in-premature-babies-to-identify-biomarkers-linked-to-cognitive-and-behavioral-disorders/?sc=rsin Wed, 18 Oct 2017 12:05:26 EST Investigator at Children's Hospital Los Angeles is awarded $1.7 million by the NIH to study the impact of prematurity on brain development. The goal of the study is to develop biomarkers for early detection of risk for cognitive problems and behavioral disorders in premature infants. Children's Hospital Los Angeles Saban Research Institute /articles/first-randomized-trial-to-determine-most-effective-least-toxic-treatment-for-babies-with-scid/?sc=rsin /articles/first-randomized-trial-to-determine-most-effective-least-toxic-treatment-for-babies-with-scid/?sc=rsin Thu, 05 Oct 2017 15:05:45 EST Investigators plan to determine the lowest dose of chemotherapy needed for babies with severe combined immunodeficiency undergoing bone marrow transplant. The goal is to restore the immune system safely and effectively with less toxicity than the higher dose regimens currently in use. Children's Hospital Los Angeles Saban Research Institute /articles/when-good-immune-cells-turn-bad/?sc=rsin /articles/when-good-immune-cells-turn-bad/?sc=rsin Thu, 21 Sep 2017 14:05:40 EST Investigators at CHLA have identified the molecular pathway used to foster neuroblastoma and demonstrated use of a clinically available agent, ruxolitinib, to block the pathway. Children's Hospital Los Angeles Saban Research Institute /articles/michael-pulsipher-md-of-the-children-s-center-for-cancer-and-blood-diseases-at-children-s-hospital-los-angeles/?sc=rsin /articles/michael-pulsipher-md-of-the-children-s-center-for-cancer-and-blood-diseases-at-children-s-hospital-los-angeles/?sc=rsin Wed, 06 Sep 2017 18:05:53 EST The grant provides support for an innovative clinical trial that seeks to compare outcomes for young patients with newly diagnosed severe aplastic anemia - comparing the use of unrelated-donor blood and marrow transplant to immune suppression therapy. Children's Hospital Los Angeles Saban Research Institute /articles/investigating-the-mechanisms-of-metastasis/?sc=rsin /articles/investigating-the-mechanisms-of-metastasis/?sc=rsin Tue, 05 Sep 2017 14:05:09 EST To understand metastasis, Yves DeClerck, MD, of Children's Hospital Los Angeles has studied the tumor microenvironment for his entire career. He has recently been awarded $2.2 million from the National Cancer Institute, to investigate the microenvironment from a relatively new context. Children's Hospital Los Angeles Saban Research Institute /articles/is-childhood-obesity-a-psychological-disorder/?sc=rsin /articles/is-childhood-obesity-a-psychological-disorder/?sc=rsin Tue, 22 Aug 2017 06:00:36 EST Researchers use fMRI to compare neural responses to food cues in both overweight and lean adolescents and observe that adolescents at an increased risk for obesity had less neural activity in areas of the brain responsible for self-regulation and attention. Children's Hospital Los Angeles Saban Research Institute /articles/chla-researcher-awarded-1-9-million-by-nih-to-study-novel-approach-to-battling-neuroblastoma/?sc=rsin /articles/chla-researcher-awarded-1-9-million-by-nih-to-study-novel-approach-to-battling-neuroblastoma/?sc=rsin Tue, 15 Aug 2017 15:05:07 EST Muller Fabbri, MD, PhD, of the Children's Center for Cancer and Blood Diseases at Children's Hospital Los Angeles, has been awarded $1.9 million by the National Cancer Institute of the NIH to further his research on neuroblastoma. Children's Hospital Los Angeles Saban Research Institute /articles/new-biomarker-assay-detects-neuroblastoma-with-greater-sensitivity/?sc=rsin /articles/new-biomarker-assay-detects-neuroblastoma-with-greater-sensitivity/?sc=rsin Thu, 22 Jun 2017 12:05:59 EST Investigators at The Saban Research Institute of Children's Hospital Los Angeles have developed and tested a new biomarker assay for quantifying disease and detecting the presence of neuroblastoma even when standard evaluations yield negative results for the disease. Children's Hospital Los Angeles Saban Research Institute /articles/new-tool-for-analyzing-mouse-vocalizations-may-provide-additional-insights-for-autism-modeling/?sc=rsin /articles/new-tool-for-analyzing-mouse-vocalizations-may-provide-additional-insights-for-autism-modeling/?sc=rsin Thu, 04 May 2017 16:05:03 EST Vocalization plays a significant role in social communication across species such as speech by humans and song by birds. Male mice produce ultrasonic vocalizations in the presence of females and both sexes sing during friendly social encounters. Children's Hospital Los Angeles Saban Research Institute /articles/pid1-gene-enhances-effectiveness-of-chemotherapy-on-brain-cancer-cells/?sc=rsin /articles/pid1-gene-enhances-effectiveness-of-chemotherapy-on-brain-cancer-cells/?sc=rsin Tue, 11 Apr 2017 06:00:00 EST Investigators at Children's Hospital Los Angeles have found that the gene PID1 enhances killing of medulloblastoma, the most commonly occurring malignant primary brain tumor in children, and glioblastoma, the most commonly occurring malignant primary brain tumor in adults. Children's Hospital Los Angeles Saban Research Institute /articles/chla-receives-1-3-million-from-nih-for-undergraduate-biomedical-research-training-program/?sc=rsin /articles/chla-receives-1-3-million-from-nih-for-undergraduate-biomedical-research-training-program/?sc=rsin Mon, 27 Mar 2017 13:05:07 EST Emil Bogenmann, PhD, EdD, at The Saban Research Institute of Children's Hospital Los Angeles, received $1.3 million from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) of the NIH to provide biomedical research training to disadvantaged college undergraduates. Children's Hospital Los Angeles Saban Research Institute /articles/brain-architecture-alters-to-compensate-for-depression/?sc=rsin /articles/brain-architecture-alters-to-compensate-for-depression/?sc=rsin Fri, 03 Mar 2017 17:05:17 EST A study led by Ravi Bansal, PhD, and Bradley S. Peterson, MD, of The Saban Research Institute of Children's Hospital Los Angeles, has found structural differences in the cerebral cortex of patients with depression and that these differences normalize with appropriate medication. Children's Hospital Los Angeles Saban Research Institute /articles/chla-researcher-awarded-1-7-million-to-study-heart-regeneration/?sc=rsin /articles/chla-researcher-awarded-1-7-million-to-study-heart-regeneration/?sc=rsin Tue, 28 Feb 2017 11:05:55 EST An investigator at The Saban Research Institute of Children's Hospital Los Angeles, has been awarded nearly $1.7 million, over a four year period, from the National Heart, Lung, and Blood Institute to study the molecular and cellular mechanisms of the heart's circulatory system. Children's Hospital Los Angeles Saban Research Institute /articles/resveratrol-may-be-an-effective-intervention-for-lung-aging-and-the-ultimate-development-of-chronic-lung-disease/?sc=rsin /articles/resveratrol-may-be-an-effective-intervention-for-lung-aging-and-the-ultimate-development-of-chronic-lung-disease/?sc=rsin Wed, 22 Feb 2017 18:05:40 EST Researchers demonstrate, for the first time that inhaled resveratrol treatments slow aging-related degenerative changes in mouse lung. Lung aging, characterized by airspace enlargement and decreasing lung function, is a significant risk factor for chronic human lung diseases. Children's Hospital Los Angeles Saban Research Institute /articles/less-is-more-exposure-to-stimuli-for-overcoming-phobia/?sc=rsin /articles/less-is-more-exposure-to-stimuli-for-overcoming-phobia/?sc=rsin Mon, 06 Feb 2017 06:30:00 EST A team of investigators, led by Bradley S. Peterson, MD, director of the Institute for the Developing Mind at Children's Hospital Los Angeles, and Paul Siegel, PhD, associate professor of psychology at Purchase College of the State University of New York, have found that exposure to phobic images without conscious awareness is more effective than longer, conscious exposure for reducing fear. Children's Hospital Los Angeles Saban Research Institute /articles/short-bowel-syndrome-results-in-changes-to-gene-expression/?sc=rsin /articles/short-bowel-syndrome-results-in-changes-to-gene-expression/?sc=rsin Wed, 25 Jan 2017 06:00:00 EST Investigators at Children's Hospital Los Angeles, led by Tracy C. Grikscheit, MD, have mapped the genetic changes resulting from short bowel syndrome (SBS) using a novel zebrafish model and by performing intensive gene sequencing. This approach to determining which genes are markedly over or under expressed in SBS may assist scientists in developing future therapies for children and adults with this condition. Children's Hospital Los Angeles Saban Research Institute