display Latest news from Children's Hospital of Philadelphia on News en-us Copyright 2024 News 115 31 / /images/newswise-logo-rss.gif /articles/children-s-hospital-of-philadelphia-s-center-for-data-driven-discovery-in-biomedicine-receives-up-to-10-million-arpa-h-award-to-create-tool-for-sharing-data-on-cancer-and-rare-diseases/?sc=rsin /articles/children-s-hospital-of-philadelphia-s-center-for-data-driven-discovery-in-biomedicine-receives-up-to-10-million-arpa-h-award-to-create-tool-for-sharing-data-on-cancer-and-rare-diseases/?sc=rsin Wed, 09 Oct 2024 10:00:43 EST A multi-institutional program led by researchers at the Center for Data Driven Discovery in Biomedicine (D3B) at Children's Hospital of Philadelphia (CHOP) has received up to $10 million Advanced Research Projects Agency for Health (APRA-H) Mission Office Innovative Solutions Openings award to research, validate and implement a new model for sharing and integrating data at a national level. Children's Hospital of Philadelphia /articles/researchers-at-children-s-hospital-of-philadelphia-reveal-new-insights-into-non-inflammatory-causes-of-rare-neurological-symptoms-in-children-adolescents-and-young-adults-following-car-t-therapy/?sc=rsin /articles/researchers-at-children-s-hospital-of-philadelphia-reveal-new-insights-into-non-inflammatory-causes-of-rare-neurological-symptoms-in-children-adolescents-and-young-adults-following-car-t-therapy/?sc=rsin Mon, 07 Oct 2024 14:05:40 EST Researchers at Children's Hospital of Philadelphia (CHOP) revealed for the first time that children, adolescents and young adults may experience very rare neurological issues of paraparesis and quadriparesis following chimeric antigen receptor T-cell (CAR-T) therapy, a type of immunotherapy used to treat B-cell Acute Lymphoblastic Leukemia (B-ALL). Children's Hospital of Philadelphia /articles/chop-pediatrician-tips-on-smart-phone-use-an-essential-back-to-school-guide/?sc=rsin /articles/chop-pediatrician-tips-on-smart-phone-use-an-essential-back-to-school-guide/?sc=rsin Thu, 05 Sep 2024 14:00:37 EST Children's Hospital of Philadelphia /articles/researchers-at-children-s-hospital-of-philadelphia-advocate-for-energy-drink-regulation/?sc=rsin /articles/researchers-at-children-s-hospital-of-philadelphia-advocate-for-energy-drink-regulation/?sc=rsin Wed, 04 Sep 2024 13:05:45 EST Children's Hospital of Philadelphia /articles/many-youths-continue-to-take-opioids-months-after-surgical-procedures/?sc=rsin /articles/many-youths-continue-to-take-opioids-months-after-surgical-procedures/?sc=rsin Thu, 11 Jul 2024 09:05:24 EST A multi-institutional study found that 1 in 6 youths fill an opioid prescription prior to surgery, and 3% of patients were still filling opioid prescriptions three to six months after surgery, indicating persistent opioid use and possible opioid dependence. Children's Hospital of Philadelphia /articles/children-s-hospital-of-philadelphia-researchers-find-parent-and-caregiver-support-linked-to-decreased-depression-and-suicidal-thoughts-in-lgbtq-and-non-lgbtq-youth/?sc=rsin /articles/children-s-hospital-of-philadelphia-researchers-find-parent-and-caregiver-support-linked-to-decreased-depression-and-suicidal-thoughts-in-lgbtq-and-non-lgbtq-youth/?sc=rsin Thu, 11 Jul 2024 09:05:01 EST A new study from researchers found that LGBTQ+ youth were more likely to experience depression and thoughts and attempts of suicide than non-LGBTQ+ youth, yet the prevalence of these mental health symptoms were significantly reduced when LGBTQ+ youths reported support from their parents. Children's Hospital of Philadelphia /articles/children-s-hospital-of-philadelphia-researchers-find-elementary-age-children-experience-more-concussions-during-activities-unrelated-to-sports/?sc=rsin /articles/children-s-hospital-of-philadelphia-researchers-find-elementary-age-children-experience-more-concussions-during-activities-unrelated-to-sports/?sc=rsin Thu, 27 Jun 2024 12:05:46 EST Researchers found that young children between the ages of 5 and 12 were more likely to experience a concussion from recreation and other non-sport activities, yet those injuries were not seen by specialists until days later compared with sports-related concussions in the same age group. Children's Hospital of Philadelphia /articles/chop-developed-adolescent-health-questionnaire-helps-doctors-and-families-navigate-complex-issues/?sc=rsin /articles/chop-developed-adolescent-health-questionnaire-helps-doctors-and-families-navigate-complex-issues/?sc=rsin Thu, 13 Jun 2024 10:05:00 EST While doctors understand that adolescents have certain unique health questions and concerns, several challenges prevent this critical information from being collected in a systematic way and providing appropriate referrals across a wide group of patients. Children's Hospital of Philadelphia /articles/chop-researchers-develop-easy-to-use-screening-tool-to-help-improve-family-access-to-federal-nutrition-programs/?sc=rsin /articles/chop-researchers-develop-easy-to-use-screening-tool-to-help-improve-family-access-to-federal-nutrition-programs/?sc=rsin Thu, 30 May 2024 00:05:45 EST Researchers developed, implemented and successfully tested a nutrition screener to improve access to healthy resources for families eligible for federally funded food benefits. Children's Hospital of Philadelphia /articles/chop-researchers-identify-causal-genetic-variant-linked-to-common-childhood-obesity/?sc=rsin /articles/chop-researchers-identify-causal-genetic-variant-linked-to-common-childhood-obesity/?sc=rsin Wed, 01 May 2024 11:00:00 EST Researchers have identified a causal genetic variant strongly associated with childhood obesity. The study provides new insight into the importance of the hypothalamus of the brain and its role in common childhood obesity and the target gene may serve as a druggable target for future therapeutic interventions. Children's Hospital of Philadelphia /articles/researchers-publish-final-results-of-key-clinical-trial-for-gene-therapy-for-sickle-cell-disease/?sc=rsin /articles/researchers-publish-final-results-of-key-clinical-trial-for-gene-therapy-for-sickle-cell-disease/?sc=rsin Wed, 24 Apr 2024 17:00:00 EST An international consortium published the final results of a key clinical trial of the gene therapy CASGEVY (exagamglogene autotemcel) for the treatment of sickle cell disease in patients 12 years and older with recurrent vaso-occlusive crises (VOCs). Children's Hospital of Philadelphia /articles/chop-researchers-discover-underlying-biology-behind-fontan-associated-liver-disease/?sc=rsin /articles/chop-researchers-discover-underlying-biology-behind-fontan-associated-liver-disease/?sc=rsin Wed, 24 Apr 2024 14:00:00 EST As patients with congenital heart diseases live longer, researchers are attempting to understand some of the other complications they may face as they age. In a new study, a team from Children's Hospital of Philadelphia (CHOP) used state-of-the-art technologies to understand the underlying biology of Fontan-associated liver disease (FALD). Children's Hospital of Philadelphia /articles/researchers-find-no-link-between-covid-19-virus-and-development-of-asthma-in-children/?sc=rsin /articles/researchers-find-no-link-between-covid-19-virus-and-development-of-asthma-in-children/?sc=rsin Fri, 12 Apr 2024 00:05:00 EST In the wake of the COVID-19 pandemic, many families worried about the long-term effects posed by the SARS-COV-2 virus. Now, researchers found that a SARS-COV-2 infection likely does not increase the risk of asthma development in pediatric patients. The findings were published today in the journal Pediatrics. Children's Hospital of Philadelphia /articles/chop-stanford-researchers-identify-protein-that-controls-car-t-cell-longevity/?sc=rsin /articles/chop-stanford-researchers-identify-protein-that-controls-car-t-cell-longevity/?sc=rsin Wed, 10 Apr 2024 11:00:00 EST CAR T cell therapy has revolutionized the way certain types of cancer are treated, and the longer those CAR T cells live in a patient's body, the more effectively they respond to cancer. Now, researchers have found that a protein called FOXO1 improves the survival and function of CAR T cells, which may lead to more effective CAR T cell therapies and could potentially expand its use in difficult-to-treat cancers. Children's Hospital of Philadelphia /articles/youths-with-mood-disorders-30-percent-less-likely-to-acquire-driver-s-license-than-peers/?sc=rsin /articles/youths-with-mood-disorders-30-percent-less-likely-to-acquire-driver-s-license-than-peers/?sc=rsin Mon, 08 Apr 2024 11:00:00 EST Researchers found that teens and young adults with mood disorders, such as depression and bipolar disorder, were 30% less likely to obtain their driver's license than peers without such disorders. Additionally, those youths with mood disorders experienced a slightly elevated risk of crashing. Children's Hospital of Philadelphia /articles/spending-quality-time-with-their-parents-holds-great-significance-to-teens-parental-support-plays-a-crucial-role-in-shaping-adolescent-lives-hear-more-from-dr-kenneth-ginsburg-founding-director-of-the-center-for-parent-and-teen-communication-adolescent-me/?sc=rsin /articles/spending-quality-time-with-their-parents-holds-great-significance-to-teens-parental-support-plays-a-crucial-role-in-shaping-adolescent-lives-hear-more-from-dr-kenneth-ginsburg-founding-director-of-the-center-for-parent-and-teen-communication-adolescent-me/?sc=rsin Thu, 04 Apr 2024 13:00:47 EST Children's Hospital of Philadelphia /articles/chop-researchers-find-branched-chain-amino-acid-supplementation-may-aid-in-concussion-recovery/?sc=rsin /articles/chop-researchers-find-branched-chain-amino-acid-supplementation-may-aid-in-concussion-recovery/?sc=rsin Tue, 19 Mar 2024 10:05:20 EST In the first clinical trial of a targeted pharmacologic therapeutic for mild traumatic brain injury in pediatric patients, scientists have found preliminary evidence that adolescents and young adults with concussion who take a specific formulation of branched chain amino acid (BCAA) supplements after injury experience faster symptom reduction and return to physical activity. Children's Hospital of Philadelphia /articles/chop-researchers-discover-key-metabolic-process-responsible-for-rapid-immune-responses/?sc=rsin /articles/chop-researchers-discover-key-metabolic-process-responsible-for-rapid-immune-responses/?sc=rsin Fri, 15 Mar 2024 14:00:00 EST Researchers identified a key metabolite in cells that helps direct immune responses and explains at a single cell level why immune cells that most efficiently recognize pathogens, vaccines, or diseased cells grow and divide faster than other cells. Children's Hospital of Philadelphia /articles/chop-researchers-improve-fitness-of-cells-used-in-cell-transplants/?sc=rsin /articles/chop-researchers-improve-fitness-of-cells-used-in-cell-transplants/?sc=rsin Wed, 27 Sep 2023 09:50:33 EST A readily available, inexpensive small molecule drug can improve the fitness of hematopoietic stem and progenitor cells (HSPCs) that are modified outside of the body, potentially improving the success of procedures like ex vivo gene therapy, according to a new study by researchers at Children's Hospital of Philadelphia (CHOP). Children's Hospital of Philadelphia /articles/chop-researchers-develop-versatile-and-low-cost-technology-for-targeted-long-read-rna-sequencing/?sc=rsin /articles/chop-researchers-develop-versatile-and-low-cost-technology-for-targeted-long-read-rna-sequencing/?sc=rsin Tue, 15 Aug 2023 14:05:49 EST In a development that could accelerate the discovery of new diagnostics and treatments, researchers at Children's Hospital of Philadelphia (CHOP) have developed a versatile and low-cost technology for targeted sequencing of full-length RNA molecules. Children's Hospital of Philadelphia