麻豆传媒

My research centers on the physiological mechanisms underlying the normal maternal physiological responses to pregnancy and the pregnancy complications of fetal growth restriction and preeclampsia. I use the chronic hypoxia of residence at high altitude (>2500 m or 8000 ft) as a natural laboratory for studying these mechanisms since high altitude exerts one of the strongest influences on fetal growth (being second in magnitude only to gestational age) and triples the frequency of preeclampsia. With students, fellows and faculty colleagues from obstetrics & gynecology and other disciplines (anesthesiology, anthropology, cancer biology, genetics, medicine, pediatrics, physiology, and public health) and the aid of NIH, NSF or other federal funding, we have published more than 200 articles documenting the effects of chronic hypoxia on maternal and fetal well being. In particular our human studies have shown that altitude lowers birth weight an average of 102 g/1000 m and is associated with less pregnancy-associated rise in uterine artery blood flow, due in turn to smaller uterine artery diameters. Experimental animal studies have shown that chronic hypoxia vs. normoxia reduces uterine artery nitric oxide production, vasodilator response to flow, growth and remodeling, suggesting that chronic hypoxia interferes with the normal maternal uterine vascular responses to pregnancy. Multigenerational populations (Andeans, Tibetans) are largely protected from hypoxia-associated fetal growth restriction, due in part to being able to attain greater uterine artery diameter and blood flow than shorter-term residents (Europeans, Chinese). Our recent whole-genome scan and gene-expression studies have identified several genes likely involved. Current work is aimed at identifying the specific gene variants and physiological mechanisms by which they exert their effects with hopes that such studies will aid not only in understanding processes of evolutionary adaptation but also our ability to identify persons at risk for pregnancy complications and/or design more effective therapies for their treatment or prevention.

Education:
BA, Anthropology (1968), Smith College
PhD Biomedical Anthropology (1973), University Michigan (Ann Arbor).

Audrey A. Vasauskas, PhD, serves as Director of Research & Grant Development and Associate Professor of Physiology. Dr. Vasauskas obtained her Bachelor of Science in biology from Mount Saint Mary鈥檚 University in Maryland. She earned her PhD and completed post-doctoral training from the University of South Alabama College of Medicine. Dr. Vasauskas has been the recipient of several extramural research grants from the National Institutes of Health and the American Heart Association. She has also served as a science policy and research advocate to the United States Congress. Dr. Vasauskas has been teaching cell and system physiology for over a decade and has mentored many undergraduate, graduate and medical students both in academia and industry. Prior to her career in academia, she spent several years in the biotechnology industry as project leader for oncology diagnostic development. During her time at ACOM, she has served as Research Committee chair and principal investigator. Dr. Vasauskas鈥檚 current research includes the molecular changes that occur within endothelial cells in the pathology known as pulmonary arterial hypertension. Specifically, her NIH-funded research investigates potential players in endothelial to mesenchymal transition, or the process by which endothelial cells transition to a smooth muscle, constrictive phenotype.

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