麻豆传媒

Prof. Spangler鈥檚 research aims to expand the repertoire of protein therapeutics by redesigning naturally occurring proteins and engineering new molecules to overcome the deficiencies of existing drugs. Integrating cutting-edge tools from structural biophysics, biomolecular engineering, and translational immunology, her research focuses on developing innovative platforms for the discovery and design of proteins that recruit novel mechanisms for disease therapy. In particular, Spangler鈥檚 group is interested in engineering antibody-based molecules that reshape immune cell behavior for targeted treatment of cancer, infectious diseases, and autoimmune disorders. The overarching goal of her interdisciplinary research program is to establish new insights into protein behavior and the extent to which it can be manipulated for medically relevant applications.

Marian Hettiaratchi and members of her lab work to develop protein delivery vehicles for regenerative medicine by integrating cutting-edge techniques in protein engineering, polymer chemistry, and computational modeling to design versatile, clinically-relevant biomaterials. Hettiaratchi is a recipient of an NIH R21 Trailblazer Award for her project, 鈥淎 Directed Evolution Approach to Affinity-Based Protein Delivery.鈥�  She was a postdoctoral fellow at the University of Toronto after receiving her PhD in biomedical engineering from Georgia Institute of Technology and Emory University. She joined the UO faculty in 2020 and holds an affiliate appointment at Oregon Health & Science University. 

 
Brenda Anne Wilson is a Professor of microbiology in the School of Molecular & Cellular Biology at the University of Illinois Urbana-Champaign. She also is the Inaugural Professor of Biomedical and Translational Sciences in the Carle Illinois College of Medicine, an adjunct professor of pathobiology in the College of Veterinary Medicine; and the Sandia Senior Faculty Fellow in the university's Office of the Vice Chancellor for Research and Innovation. 
Wilson is a fellow of the American Academy of Microbiology and a member of the AAM Selection Committee, and an American Society for Microbiology Distinguished Lecturer.
She was a DAAD graduate exchange Fellow in biochemistry at Ludwig-Maximilians Universität München, Germany. While earning her PhD at Johns Hopkins University, she was an AAUW doctoral fellow and studied antibiotic biosynthesis. She then undertook her NIH postdoctoral fellowship training in microbiology at Harvard Medical School, where she began her studies on bacterial protein toxins. Her first tenured faculty appointment was in biochemistry at Wright State University School of Medicine, Dayton, Ohio.
As inaugural leader of the Host-Microbe Systems Theme of the Woese Institute for Genomic Biology at the University of Illinois for 10 years, Wilson brought together faculty and scientists from multiple disciplines across campus, including microbiology, anthropology, animal sciences, engineering, and veterinary pathobiology to forge new areas of microbiome research. She served for 10 years on the executive committee of the Great Lakes Regional Center for Excellence in Biodefense and Emerging Infectious Diseases. As co-director of the University of Illinois Center for Zoonoses Research, she has promoted the One-Health Initiative and training of DVM students in research through summer training experiences. For nearly 20 years she has served as Biosecurity Leader of the Executive Committee of the University of Illinois Program in Arms Control, Domestic and International Security, where she has engaged events promoting scientific literacy and bridging the gap between scientists and educators, policy makers, government officials, and the public.
Wilson is currently president of the Champaign-Urbana Branch of the American Association for University Women, where she helps organize and convene community outreach events aimed at advancing equity and higher education opportunities for women and girls, particularly in STEM areas. As director for undergraduate education in the School of Molecular and Cellular Biology, she helps oversee the delivery of all academic, advising, and curricular aspects of the BS in MCB, BS in Biochemistry, BS in Neuroscience, and the forthcoming BS in MCB + Data Science undergraduate programs and the MS in MCB graduate programs. As the Sandia Senior Faculty Fellow in the Office of the Vice-Chancellor for Research and Innovation, she fosters, engages, and sustains research collaborations in STEM disciplines, including building workforce pipelines between scientists at the University of Illinois and the U.S. Department of Energy's national labs.
Research interests
Wilson’s research focuses on the host-microbe interface, bacterial pathogenesis and bacterial protein toxins, development of anti-toxin and toxin-based therapeutic biologics, comparative and functional genomic technologies and applications involving microbiomes and their roles in health and disease, climate change impacts on microbiomes, health, and disease transmission, and development of technologies and applications for detection and risk assessment of Dual Use Research of Concern (DURC) objects, publications, and activities. She has published over 150 scientific articles, chapters, and books, including the highly acclaimed textbook Bacterial Pathogenesis: A Molecular Approach (4th Edition, 2019, ASM Press/John Wiley) and the recent Revenge of the Microbes: How Bacterial Resistance is Undermining the Antibiotic Miracle (2nd Edition, 2023, ASM Press/John Wiley).
Education
BA (Biochemistry and German), Barnard College/Columbia University, 1981
Biochemistry Diplomarbeit (Post-baccalaureate Program), Deutscher Akademischer Austauschdienst (DAAD), Ludwig-Maximilians Universität, Munich, Germany, 1981-1982
M.S./Ph.D. (Chemistry), Johns Hopkins University, 1989
Postdoctoral (Microbiology and Molecular Genetics), Harvard Medical School, 1989-1993
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