麻豆传媒

Expert Directory

Agriculture, crop improvement, crop management, Crops, Soybean

(he/him) develops sustainable strategies to manage plant nematodes. He studies the molecular and biochemical basis of plant-nematode interactions in order to determine how plant parasitic nematodes evade plant resistance mechanisms.

More information:

Lambert is the Director of Undergraduate Programs and an associate professor in the Department of Crop Sciences at the University of Illinois who's passionate about studying and developing sustainable methods to manage plant nematodes in crops. Lambert's latest research contribution investigates the methods and ability to express single-stranded RNA constructs transiently as a method to evaluate nematode and foreign genes for their biological significance and potential role in nematode management. Just a few more of his most recent research endeavors also include the discovery of a new member of the Carlavirus genus from randomly collected soybean leaves in Illinois, methods for measuring virulence in soybean cyst nematode, and the investigation of a new response mechanism towards plant nematode resistance involving haplotype compatibility, gene dosage, and hormone signaling.

Affiliations:

Dr. Lambert is an associate professor in the  in the  (ACES) at the . He is also the Director of Undergraduate Programs.

 

Agriculture, crop improvement, Crops, Maize, Statistics

(he/him) is a research and associate professor who studies and develops methods to accelerate the development of high-performing crops by identifying specific DNA regions associated with agronomically important traits. He uses statistical approaches for quantitative genetic analyses in crops as well.

More information:

Lipka is a researcher and associate professor passionate about the development of sustainable and high-performing crop practices. In pursuit of this passion, he leads the Lipka Lab at the University of Illinois with the research aim of creating statistical approaches to analyze quantitative genetics data. Lipka's research interests include multidisciplinary collaborations that focus on various genomic-related issues, including the contributions of nonadditive effects to phenotypic variation and the identification of genomic variants associated with agronomic and health-related traits. Some of his research endeavors include the investigation of crop productivity based on the activity of meristems to facilitate further genetic studies and the study into the diversity, genomic complexity, population structure, phylogeny, phylogeography, ploidy, and evolutionary dynamics of switchgrass. Lipka also led a study that developed an R package called Genome Association and Prediction Integrated Tool to handle larger datasets for genome-wide association studies and genomic prediction and selection studies. Prior to joining the University of Illinois, Lipka received his Bachelor of Science in Statistics at the University of Flordia and went on to get his Master of Science and Ph.D. at Purdue University. Lipka was also a postdoctoral associate at Cornell University.

Affiliations:

Dr. Lipka is an associate professor in the  in the  (ACES) at the .

Karin Arsenault, DMD, MPH

Hilde H. Tillman, D49, Professor in Geriatric Dentistry

Tufts University

community-based care, dental education , Health Care Policy, Oral Health, Public Health

Clinical director of Tufts University School of Dental Medicine's geriatric center program, Dr. Arsenault's research interests include public health, geriatrics, Iinterprofessional practice education, and health care policy and reimbursement issues.

Sean Cash, PhD

Chair of the Division of Agriculture, Food and Environment, and Bergstrom Foundation Professor in Global Nutrition

Tufts University

consumer choices, Food and environment, Food Labelling, Food Production, health messages

Sean B. Cash is an economist with the Friedman School of Nutrition Science and Policy at Tufts University. His research focuses on how food, nutrition, and environmental interventions and policies affect both producers and consumers. Ongoing and recent projects in this area include the efficacy of food label and price interventions as public health and environmental tools, including linkages to disease incidence; children’s food choices in commercial and school environments; consumer interest in cellular agriculture; food labeling of ethical attributes of food production; online food retailing; and how point-of-sale health messaging impacts consumers’ demand for food. He also conducts research in the areas of environmental impacts in food production, including projects on climate change and coffee/tea production and invasive species management.

Food Production, heat and drought, Humanitarian Response

Erin Coughlan de Perez bridges science, policy, and practice in her research on climate risk management around the world. She focuses on extreme events, exploring how droughts, floods, heatwaves, and other climate shocks can be anticipated before they happen. Erin works with humanitarian teams on the development of early action protocols to avoid disaster impacts, and she researches the adoption and effectiveness of climate change adaptation measures. She is a research director at the Feinstein International Center at Tufts University.

Politics, Social Change, sociology of religion, Stratification

BIO

Philip Schwadel’s research explores the changing nature of Americans’ religious and political perspectives, addressing changes over time and between generations. He has examined how higher education and social status influence religious belief. He searches for social influences, emphasizing how religious congregations, social networks, age, time and other social contexts influence religion and politics. He holds a Ph.D. from Pennsylvania State University, where he was a postdoctoral researcher with the National study of Youth and Religion for two years. He has been a faculty member in UNL’s Department of Sociology since 2005.

 

My research focuses on religion and politics in the United States, with an emphasis on social status, social contexts, and social change. The association between social class and religious beliefs, practices, and affiliations has been a long-standing interest of mine, going back to my dissertation. My research also explores the changing nature of Americans’ religious and political perspectives, addressing both temporal and generational changes. Combining these areas of research, some of my work examines generational changes in the association between social class and religious and political perspectives. Always looking for the social influence, my work emphasizes how social contexts of various kinds—including religious congregations, social networks, and generational and temporal contexts—affect religious and political outcomes. Information on my publications can be found at my  and  pages.

 Current Research

Building on the work I did with the  while on leave from UNL in 2018-2019, I am now returning to some of my earlier work on adolescent religion in the U.S. I plan on writing a series of articles looking at the role of religion in school, how teenagers navigate religion among their friends, and the prevalence and consequences of religious bullying in school.

At the same time, I am continuing to use existing survey data to further explore the associations between religion and politics and the changing nature of American religion. This research focuses on the direct and indirect effects of religious affiliations and beliefs on political outcomes such as party affiliation, political tolerance, and views of government spending. I also have an ongoing project on social networks in churches. My colleagues and I have collected network data in three churches. I plan to continue this line of research with both additional churches and additional waves of data collection within the same church.

Most recently, I have been working with colleagues in psychology to examine the social-psychological consequences of religious disaffiliation. The proportion of Americans who have no religion has grown tremendously—from about 7% in 1990 to between a quarter and a third of the population today. Our work examines how Americans who leave religion often retain some of the psychological dispositions associated with being religious. We refer to this as the “religious residue effect.”

 Current Teaching

I teach various courses on religion, including Sociology of Religion, Sociology of Global Religious Diversity, and a graduate seminar on religion. I also teach Social Problems, Sociological Theory, and the graduate-level publications seminar.

 Student Opportunities

I regularly publish with graduate students. For instance, I recently published work on religious change among lesbian, gay, and bisexual young adults in the United States (with Brandi Woodell, former UNL graduate student and current faculty member at Old Dominion University) and on changes in the effects of social class on political tolerance (with Christopher Garneau, former UNL graduate student and current faculty member at University of Science and Arts of Oklahoma). I have works-in-progress with graduate students (current and former) on political messages and support for environmental initiatives, on the association between the religious makeup of a community and the prevalence of hate crimes, and on the effects of education on support for capital punishment. I also plan to do more with the data we collected on social networks in churches, with opportunities for student involvement.

Max Perry Mueller, PhD

Assistant Professor, Classics & Religious Studies

University of Nebraska-Lincoln

Race and religion, Religion And Politics

Max Perry Mueller is a historian of American religion. He focuses on the intersection of religion, race and politics in the 19th Century, with related areas of research and teaching in the history of the American West, religion and modernity, religion and politics and religion and journalism. He has written on religion, race and politics for Slate, The New Republic and The Atlantic, including several articles on Mormonism’s role in the 2016 presidential election.

Max Perry Mueller (PhD, Harvard University) is an assistant professor in the Department of Classics and Religious Studies. He is also a fellow at the Center for Great Plains Studies and teaches in the Department of History, the Honors Program, and the Global Studies program.

Mueller is a theorist and historian of race and religion in American history, with particular interest in Indigenous and African-American religious experiences, epistemologies, and cosmologies. The central animating question of his scholarship is how the act of writing—especially the writing of historical narratives—has affected the creation and contestation of "race" as a category of political and religious division in American history.

His first book, Race and the Making of the Mormon People (The University of North Carolina Press, 2017), examines how the three original American races—"red," "black," and "white"—were constructed as literary projects before these racial categories were read onto bodies of Americans of Native, African, and European descent. Choice described Race and the Making of the Mormon People as an "outstanding analysis of the role of race among Mormons." The book was featured in The Atlantic and Harvard Divinity School Bulletin and has been taught at, among others, Princeton, Harvard, and Stanford Universities. His next book, Wakara's America, will be the first full-length biography of the complex and often paradoxical Ute warrior chief, horse thief, slave trader, settler colonist, one-time Mormon, and Indian resistance leader.

Mueller's research and teaching also connect with his public scholarship. Mueller has written on religion, race, and politics for outlets including SlateThe New Republic, and The Atlantic. He also co-founded Religion & Politics, the online journal of the John C. Danforth Center on Religion & Politics at Washington University in St. Louis, whose mission is to bring the best scholarship on religion and American public life to audiences beyond the academy.

 

Neil Dello Russo, PhD

Planetary Astronomer, Cometary Scientist, Molecula Spectroscopist

Johns Hopkins University Applied Physics Laboratory

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I have experience in the acquisition, analysis, and interpretation of laboratory infrared spectroscopic data, including high-resolution gas-phase and moderate-resolution solid phase spectroscopy of astrophysically relevant molecules, and in the acquisition of high and moderate-resolution astronomical data with infrared spectrometers on large telescopes. These include the high-resolution Cryogenic Echelle Spectrometer (CSHELL), and the moderate resolution (0.8-5.4-µm) spectrometer SpeX at the NASA Infrared Telescope Facility and the high and moderate-resolution Near-Infrared Spectrometer (NIRSPEC) at the Keck Observatory, the high-resolution IRCS spectrometer at the Subaru Observatory, and the very high-resolution CRIRES spectrometer at the ESO VLT.  I also have extensive experience in analysis and interpretation of high-resolution near-infrared astronomical array data.  This includes development of data processing routines, quantitative analysis, and interpretation of data obtained with infrared spectrometers.  The data I obtained and analyzed are primarily on comets, but also Mars, Jupiter, asteroids, exoplanets, and young stellar objects. Finally, I have extensive experience in the development of low-temperature fluorescence models for molecules with relevance to comets and other cold environments (e.g. H2O, C2H6, HCN, C2H2, CO, NH3, CH4, OCS).

Notable Awards and Leadership
Year(s) Description
2013 - Present Science Steering Committee Member for the commissioning of the iSHELL spectrometer at the NASA/IRTF
2014 - 2015 Science Organizing Committee Chair for the 2015 DPS Meeting
2014 - 2015 Local Organizing Committee Member for the 2015 DPS Meeting
2012 - 2015 Small Bodies Assessment Group (SBAG) Steering Committee Member
2007 - 2008 Local Organizing Committee Member for the 2008 ACM Meeting

 

  • PhD, Physical Chemistry
    1994, University of Maryland at College Park
  • BA, Physics
    1988, Gettysburg College

David Shrekenhamer, PhD

Program Manager of Physics, Electronic Materials, and Device Research

Johns Hopkins University Applied Physics Laboratory

Chirality, Electromagnetic Spectrum, Electronic Materials, Physics



Nicole Tichenor Blackstone, PhD

Assistant Professor in the Division of Agriculture, Food, and Environment

Tufts University

Food and environment, Food Policy, food systems, Life Cycle Assessment, Social Responsibility, Sustainability

Nicole Tichenor Blackstone is an Assistant Professor in the Division of Agriculture, Food, and Environment at the Friedman School of Nutrition Science and Policy at Tufts University. Her research focuses on developing and evaluating strategies to improve food system sustainability. Dr. Blackstone’s work fuses industrial ecology, nutrition, and social science methods. To date, her research has explored the environmental and social implications of diverse production systems (e.g., grass-fed beef, cultivated meat, fruits and vegetables), human diets, and regional food systems. 

Athanasios Zavras, DDS

Chair and Professor of Public Health and Community Service

Tufts University

Caries, Oral Cancer, Oral Health

Dr. Athanasios Zavras is the Delta Dental of Massachusetts Professorship in Public Health and Community Service and chair and professor of Public Health and Community Service at Tufts University School of Dental Medicine. His research interests include health services research and oral epidemiology, including the molecular epidemiology of oral epithelial cancer, bisphosphonate-induced osteonecrosis of the jaw, and early childhood caries. Dr. Zavras has conducted the first genome-wide association study of Bisphosphonate-related osteonecrosis of the jaw (BRONJ) to discover regions of genetic susceptibility. 

Erin Hennessy, PhD, MPH

Director of ChildObesity180, Assistant Professor

Tufts University

Childhood Obesity, community-based interventions, Food Policy

Erin Hennessy is Director of ChildObesity180 and Assistant Professor at the Friedman School of Nutrition Science and Policy at Tufts University. Dr. Hennessy has focused her career on helping all children eat better, move more and achieve a healthy weight with a particular emphasis on helping those most in need. Her work addresses modifiable risk factors across levels of influence including the individual, interpersonal, organizational, community and public policy.

Dr. Hennessy currently leads an active research portfolio including an $8.5 million award to test and evaluate the use of telehealth innovations in delivery of USDA’s Special Supplemental Nutrition Program for Women, Infants, and Children (WIC); and, co-leads a $1.3 million grant from the National Institutes of Health, in collaboration with the New York Road Runners organization, to create and implement a multilevel intervention to support children’s physical literacy at school and home. She is also the PI of several pilot studies focused on nutrition, physical activity and obesity prevention in early childhood.

Big Data, Business Analytics, Computing, Information Systems, Machine Learning

Balaji Padmanabhan has a bachelor's degree in computer science from Indian Institute of Technology (IIT) Madras and a PhD from New York University’s Stern School of Business and has worked in the data science, AI/machine learning and business analytics areas for 25 years. His current work addresses the design of artificial and augmented intelligence solutions that combine data, machine learning and modeling the real-world through complex systems simulations and has broad applications across business, policy, media and healthcare. He has published extensively in data science and related areas at premier journals and conferences in the field and has served on the editorial board of leading journals including Management Science, MIS Quarterly, INFORMS Journal on Computing, Information Systems Research, Big Data, ACM Transactions on MIS and the Journal of Business Analytics. 

Elina Hypponen, PhD

Director of the Australian Centre for Precision Health

University of South Australia

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Professor Hyppönen is the Director of the  at the University of South Australia Cancer Research Institute. She was recruited to the University of South Australia as the Professor in Nutritional and Genetic Epidemiology in 2013, following 12 years at the University College London, Great Ormond Street Institute of Child Health (London, UK).

She also holds appointments as a Senior Principal Research Fellow at the South Australian Health and Medical Research Institute (SAHMRI) and as an Adjunct Professor in Epidemiology at the University of Tampere, Finland. Professor Hyppönen has an interdisciplinary academic background, with academic qualifications in epidemiology, medical statistics, nutrition and public health.

Professor Hyppönen has a H-factor of 83, and her work has been cited over 43,000 times.  She has authored more than 200 high-profile refereed publications and several book chapters. She leads the which has a focus on using genetic tools to inform on dietary and lifestyle guidelines for optimal health. She has a long-term research interest in life-course and intergenerational epidemiology, and an extensive track record in gene and risk factor discovery. Her current interests are related to implementing phenomewide analyses and systems epidemiology approaches to establish effective strategies for disease prediction and prevention. 

Rietie Venter, PhD

Associate Professor Clinical & Health Sciences

University of South Australia

antimicrobial resistance , Biochemistry and Cell Biology, Multidrug Resistance

I obtained my BSc Hons and Master’s degrees with distinction from the University of the Free State in South Africa. As top student in my BSc Hons class I secured an international scholarship to fund my PhD studies at the University of Leeds. After completing my PhD on membrane protein biochemistry at the University of Leeds in the beautiful Yorkshire Dales, I moved to Cambridge, where I spend twelve years doing research on multidrug transporters, first as a post-doc and later running my own research group as a Royal Society Dorothy Hodgkin Fellow in the Department of Pharmacology at the University of Cambridge. During this time, I was also appointed as College Lecturer in Robinson College, University of Cambridge, where I did small-group tutoring and teaching. Not content with moving continents once in a lifetime, I left the ancient buildings and immaculate college lawns of Cambridge for sun and sea in Australia after sixteen years in the UK. I joined the University of South Australia as Senior Lecturer and Head of Microbiology in the School of Pharmacy and Medical Sciences in December 2012.

 

Current research & highlights
My research focuses on antimicrobial resistance. ‘Superbugs’ are costing the medical and veterinary industry billions of dollars a year and antimicrobial resistance is one of the world’s most pressing health problems. According to the WHO we are fast approaching a post-antibiotic era where small injuries and minor infections will once again be fatal. Work in my laboratory is aimed at finding novel ways of treating infectious disease by characterising bacterial membrane proteins that are involved in drug resistance and/or virulence and on developing drugs that act on these targets. We are currently working on drug efflux pumps, iron transporters and cell division proteins in pathogenic bacteria. Most of our work focusses on the Gram-negative pathogen P. aeruginosa. This pathogen is associated with a range of life-threatening nosocomial infections and is the main cause of mortality in patients with cystic fibrosis. P. aeruginosa infections are hard to treat since this organism displays resistance against multiple classes of antimicrobials. Central to this bacterium’s high intrinsic drug resistance is the expression of drug efflux pumps and its ability to form antibiotic-tolerant biofilms.

Adrian Esterman, PhD

Professor of Biostatistics Allied Health & Human Performance

University of South Australia

Clinical Sciences, Nursing, Psychology

About me

I attended Beal Grammar School for Boys in Essex, UK, and left to start work at the age of 16. After several years working as a junior clerk, I enrolled in an Honours degree in Statistics at the University of Bath, graduating in 1972.  This was followed by a Masters degree in Medical Statistics at the London School of Hygiene and Tropical Medicine in 1973, supervised by Professor Peter Armitage. I then took up a Junior Research Fellowship at the University of Aberdeen medical school in late 1973 before joining the World Health Organization in 1974. I worked for 5 years at the WHO head office in Geneva, followed by 2 years at the WHO European Regional Office in Copenhagen.

In 1981 I moved to Australia and worked for many years in the South Australian Department of Health as Principal Epidemiologist. In the mid-1990s, I took a break from epidemiology and became Managing Director of a market research company. This gave me great experience in survey research, qualitative research, HR management, and sales. However, I eventually moved back into academic life, and in 2002, I received my PhD in epidemiology from Flinders University.

At the University of South Australia, one of my main roles is to provide advice on biostatistics and epidemiology to researchers in the health and medical areas. I am also a Chief Investigator on several research grants. I am the author of over 400 publications and have an  of 74. I am experienced in mentoring Research Fellows junior staff and of course PhD students.

I really enjoy writing, and have written a number of articles about epidemiology and COVID-19 on the  website. I have also written nearly 30 articles for  about COVID-19 with over 2.5 million reads.  I have published a book on . I have also become an avid tweeter - @profesterman, with over 39,000 followers. I also give presentations on the current COVID-19 situation to community, business, academic and professional groups.

Doug Brooks, PhD

Professor UniSA Clinical & Health Sciences

University of South Australia

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Professor Doug Brooks is the leader of the Mechanisms in Cell Biology and Disease Research Concentration in Clinical and Health Sciences Academic Unit and the Cancer Research Institute at the University of South Australia. Doug has over 30 years experience in medical research and is a Research Professor in Molecular Medicine at UniSA and Affiliate Professor of Cancer Pathology at Trinity College Dublin (TCD).

Doug had his initial research training in Immunology with a focus on cancer research, involving the immunochemistry of cell surface antigens and involved the translation of cancer biomarkers for B-cells into clinical practice (Becton Dickinson).

For 24 years Doug worked in the Lysosomal Diseases Research Unit at the Women’s and Children’s Hospital, on a group of genetic diseases called lysosomal storage disorders. The Lysosomal Diseases Research Unit has been responsible for significant health outcomes for this group of disorders, with the development of strategies for early screening, diagnosis and treatment (technology commercialised by BioMarin and Genzyme). This research reflects Doug's strong interest in lysosomal cell biology and a desire to develop practical applications in biochemical medicine that benefit patients and the wider community.

The Mechanisms in Cell Biology and Diseases Research Group has two main research themes involving basic and applied medical research on cancer (major theme) and immunity (collaboration involving RMIT and TCD). These project areas are heavily aligned with the national research priorities of Promoting and Maintaining Good Health, A Healthy Start to Life, Aging well and Preventative Health Care. The Mechanisms in Cell Biology and Disease Research Group's primary objective is to facilitate technological advances that result in research outcomes that can be translated into clinical practice to directly benefit cancer patients and their families.

Current research projects include:

1. ENDOSOME-LYSOSOME CELL BIOLOGY AND VESICULAR TRAFFIC.  Investigate basic endosome-lysosome cell biology and developing innovative technologies: Facilities that build capacity in cell biology have been established through competitive ARC LIEF grant funding, UniSA infrastructure support, and commercial/philanthropic funding. State of the art infrastructure has been acquired to establish: Biophysical Characterisation Facility (CD spectrometer; calorimeter; and Biacore), Advanced Intravital Imaging Facility (Zeiss 710 META NLO confocal with FLIM, multiphoton, pulsed laser and spectral capacity; Vivascope with FLIM and Horiba Raman capacity), Non-invasive Analysis technology (2 specialised IRMS); A complete histopathology facility with tissue cutting, processing and digital imaging capacity; Live cell and automated imaging facilities. These facilities directly support cutting edge cell biology research projects. There are challenges in the diagnosis, prognosis and treatment of cancer that necessitates further research into the pathogenic process. The endosome-lysosome compartments are often abnormally located in cellular periphery of cancer cells and this is involved in progression of the cancer to metastasis. Retrograde and anterograde traffic facilitates homeostatic localisation of endosomes-lysosomes in cells and we are studying how vesicular traffic aligns with the development of cancer metastasis.

2.   DEVELOPMENT OF BIOMARKERS FOR PROSTATE CANCER, COLORECTAL CANCER (CRC), MELANOMA AND OTHER CANCERS. Involves the study of altered endosome biogenesis in prostate, CRC and other cancers. Every year approximately 20,000 Australian men are diagnosed with prostate cancer and more than 3,000 die of this disease. This makes prostate cancer the second largest cause of male cancer deaths and a significant health care issue, particularly in Australia where the incidence of this disease is high. We will investigate a novel aspect of endosome-lysosome cell biology in prostate cancer to identify new biomarkers. The end stage objectives for this project are therefore to develop effective methods for the early detection and prognosis of prostate cancer, which are important as this will have a major impact on patient outcome and survival. There is mounting evidence for a central role for endosome-lysosome compartments in cancer cell biology. Endosomes and lysosomes are directly involved in the critical processes of energy metabolism, cell division and intracellular signalling, and will therefore have a direct role in cancer pathogenesis. The endosome-lysosome system has a specific capacity to respond to environmental change, acting as an indicator of cellular function and will consequently be altered in cancer. Moreover, the endosome-lysosome system has a critical role in controlling the secretion of proteins into extracellular fluids, making it an ideal system to identify new biomarkers that are released from cancer cells. We therefore performed a comprehensive study of endosome-lysosome proteins in a panel of prostate cancer and non-malignant prostate cells and have demonstrated that endosome biogenesis is significantly altered. These changes in vitro have been confirmed with patient data, and we have established that the early endosome vesicular machinery is altered in prostate cancer, showing: 1. Significant increases in early endosome gene expression and protein amount, in multiple prostate cancer compared to non-malignant control cells 2. Altered distribution of early endosome organelles in prostate cancer cells 3. Altered cancer-specific early endosome gene expression in multiple prostate cancer patient datasets 4. Altered histology for early endosome proteins in prostate cancer specimens 5. Significant increases in early endosome protein secretion and concomitant decreases in late endosome protein secretion, from prostate cancer compared to non-malignant cell lines. Endosomal proteins therefore have the capacity to discriminate between prostate cancer and controls, in both cell lines and patient data bases, and none of the previously described prostate cancer biomarkers have this capacity/specificity. We are currently doing clinical trials of biomarkers in patient tissue, developing blood tests for diagnosis/prognosis, developing targeted therapeutics, developing PET imaging technology for patient imaging. We are commercialsiing this technology through Envision Sciences and also expanding our research program to focus on the primary pathogenesis in other cancers.

3. THERAPEUTIC SOLUTIONS FOR INFLUENZA AND OTHER RNA VIRUSES. We live in a world of unprecedented vulnerability with the current pandemic COVID-19 outbreak and imminent similar outbreaks due to influenza A viruses (IAV). Seasonal IAV infection continues to claim millions of lives annually and costs health care systems billions of dollars worldwide. The pathogenesis of IAV spans multiple livestock industries, which act as primary pathogenic reservoirs for the virus (e.g. birds and pigs), and given their zoonotic potential results in very significant human infection and pathogenesis. Human IAV infections cause a wide range of disease and complications encompassing acute uncomplicated disease, severe hospitalization with secondary bacterial infection, and severe hospitalization with chronic complications such as in pregnancy. However, there is neither an immediate or effective strategy to treat epidemic and pandemic IAV outbreaks nor an effective program to eradicate the virus from within the critical livestock reservoirs. The critical knowledge gaps that have hindered development of pan viral therapeutics are centred on a general lack of understanding of how the immune system both spatially and temporally regulates the disease process. In this regard, we have made 3 pioneering discoveries recently published in Nature, Cell and Nature Communications. We have demonstrated: 1) That IAV evades the immune system by promoting the production of reactive oxygen species in endosomes via a novel TLR7-NOX2 oxidase signalling axis that drives viral replication and the ensuing pathology. 2) That infection promotes a switch in cellular metabolism in immune cells, like macrophages from oxidative phosphorylation to glycolysis that drives inflammation and key intermediates for virus replication. 3) A novel powerful anti-inflammatory and anti-bacterial mediator called itaconate to be generated by the TCA cycle of metabolic pathways within immune cells. These findings have unravelled a 3-stage disease process that will ultimately necessitate a combination of therapeutic interventions. This work has also been patented: PCT/AU2018/050667 (Australian Provisional Patent Application No. AU 2017902545): Selemidis S, O’Leary J, Brooks D. “A method of treatment for viruses” and a company has been established to commercialse this technology; ViraLok Therapeutics. The therapeutic device being evaluated relates endosome biology and to the field of immunomodulation and a common conserved pathway derived over 500 million years ago.  We have developed an agent for inhibiting the heightened immune stimulation mediated by Toll-like receptor 7, which is useful in the treatment of all RNA viral pathogenesis. The inhibition of this aberrant inflammation pathway is reliant on a lead compound which is currently in pre-clinical trial. Pharmaceutical compositions are proposed and lead compound development will involve the production and formulation of mimetics. The dampening down of this immune pathway with the inhibitor results in an enhanced adaptive immune response (humoral) towards RNA and ssDNA viruses and reduced pathogenesis.

 

Javaan Singh Chahl, PhD

DST Joint Chair of Sensor Systems UniSA STEM

University of South Australia

Cognitive Sciences, Medical Technology, Neuroscience, Space Exploration

Professor Javaan Chahl is DST Group Joint Chair of Sensor Systems and has been with UniSA since 2012. Prior to this, he served as a Professor of Aerospace at RMIT University and before that he was at the Defence Science and Technology (DST) Group, with whom he still works closely. Professor Chahl earned his Ph.D. in Neuroscience & Robotics at the Australian National University. Professor Chahl has published over 200 full length refereed articles and has been referenced by other researchers more than 5,000 times. His research provides ample evidence of his breadth of expertise including avionics for drones, medical technology, space exploration, neuroscience, and behavioural biology. High points of his career have included working with NASA Ames developing Mars exploration technology and supporting his military colleagues. His research is multidisciplinary, collaborative and encompasses both theory and application. As a Research Degree Supervisor, Professor Chahl is highly sought after as a supervisor and mentor and is responsible for a large and diverse group of graduate students. His research students have gone on to attain senior academic and government research positions in Australia and overseas. He encourages collaboration, communication, with a focus on innovation, new products and new applications.

Clive Prestidge, PhD

Professor UniSA Clinical & Health Sciences

University of South Australia

Biointerfaces, Drug Delivery Systems, Nanomedicine

Clive Prestidge is currently a Professor within Clinical and Health Science, a lead researcher within UniSA's Cancer Research Institute and head of the Nanostructure and Drug Delivery research group.

Clive is the author of over 250 refereed international journal articles, textbook chapters and conference papers and over 100 major project reports to industry. He has supervised more than 35 PhD, 10 MSc and 30 Honours students and has taken a leadership role in a number of major collaborative projects in association with national and international industries, the ARC, and University researchers from Australia and overseas. Prof Prestidge has attracted competitive research grants worth more than $15M from government and industry sources.

Clive was the founder of Ceridia Pty Ltd, a clinical stage biopharmaceutical company established to commercial the the Lipoceramic drug delivery technology he invented.

The Prestidge research group is focused on Drug delivery, Nanomedicine and BioPharmaceutical Engineering. Its Primary Mission is to: (1) Engineer novel particle based biomaterials with specific biological activity and their application to solve biopharmaceutical challenges. (2) Determine mechanisms for bioactivity through advanced biophysical analysis (3) Develop drug delivery solutions to address unmet clinical needs. Some of our Grand Challenges are to: (1) Deliver Challenging Therapeutic Molecules – For Better Medicines (2) Eradicate Bacterial Biofilms (3) Optimise Biotech and Pharmaceutical Processing and Manufacture

Peter Majewski, PhD

Professor Future Industries Institute

University of South Australia

Chemical Engineering, Condensed Matter Physics, Energy Policy, Materials Science

Peter Majewski joined UniSA in January 2003 as Professorial Fellow at the Ian Wark Research Institute before he moved on to the professor position on Nanotechnology and Nanomanufacturing in the School of Advanced Manufacturing and Mechanical Engineering in January 2008 and the Head of School position in 2011. In 2013, Peter Majewski was appointed Head of School of Engineering. Since June 2016, he is Research Professor Advanced Materials in the Future Industries Institute.

He is mineralogist by training and has focused his research work mainly on nanomaterials synthesis and processing as well as nanomanufacturing. Born in Germany, he studied geology at University of Hannover, Germany, and received Diploma (4-year course) in 1985. He immediately started his PhD work on cation diffusion in silicates at the University of Hannover. In 1988, he received PhD in Mineralogy at the University of Hannover. In 1989, he joined the Max-Planck-Institute for Metals Research (MPI-MF), Department of Materials Synthesis and Microstructure Design (Powdermetallurgical Laboratory) as post doctoral fellow. His main research work was part of a long-term initiative of the Max-Planck-Institute along with other university institutes and the companies Hoechst AG, Siemens AG, and Vacuumschmelze on the development of high temperature superconducting cables and devices.

In 1992, he received the Heinz Maier Leibnitz award of the Department of Education and Science of the Federal Government of Germany for his fundamental studies on the phase relations and synthesis of novel ceramic superconductors. After several renewals, the program, which was supported by the German government, ended in 2001. At that time, Peter already became senior scientist as well as deputy department head of the Department Materials Synthesis and Microstructure Design. In addition to that, he already has switched is focus to the Solid Oxide Fuel Cells. In 1998, he set up an interdisciplinary cooperation between the MPI-MF and the Research Centre Juelich, and the German Centre for Air and Space Travel Stuttgart (DLR) on the synthesis and characterization of novel electrode and electrolyte materials for solid oxide fuel cells, which was funded by the German government. In 2000, he received the International Research Exchange Scheme Award of the Australian Research Council. In the frame of this award, he joined the Faculty of Engineering of the University of Wollongong as an International Professor Fellow, for several months during the years 2001 and 2002.

At UniSA, Peter is setting up interdisciplinary research projects in the area of material science covering fundamental and applied studies on various materials in water treatment, biomaterials, and materials for renewable energy systems. More recently, Peter's research focuses product stewardship scheme developments and circular economy aspects for emerging technologies and renewable energy technologies. He was involved in major funding initiatives by the South Australian and Federal Government as well as industry. Peter has published more than 230 papers on various topics in materials science and engineering and energy policy. His current h-index is 38.

 

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