Researchers at WashU Medicine shrink gastrointestinal tumors in mice using a yeast probiotic to deliver immunotherapy to the gut, offering a potentially novel strategy to target hard-to-reach gut cancers.
Up until recently, habituation 鈥� a simple form of learning 鈥� was deemed the exclusive domain of complex organisms with brains and nervous systems, such as worms, insects, birds, and mammals. But a new study, published Nov. 19 in Current Biology, offers compelling evidence that even tiny single-cell creatures such as ciliates and amoebae, as well as the cells in our own bodies, could exhibit habituation akin to that seen in more complex organisms with brains.
Many living organisms are able to regenerate damaged or lost tissue, but why some are particularly good at this and others are not is not fully understood. Molecular biologists Alexander Stockinger, Leonie Adelmann and Florian Raible from the Max Perutz Labs at the University of Vienna have now made an important contribution to clarifying this question in a new study.
Researchers have identified new roles for a protein long known to protect against severe flu infection 鈥� among them, raising the minimum number of viral particles needed to cause sickness.
Hematology researchers from Sylvester Comprehensive Cancer Center and the Miller School of Medicine at the University of Miami are authors or co-authors on more than 70 posters to be presented at the Annual Meeting & Exposition of the American Society of Hematology in San Diego, Dec. 7-10. Links to each abstract are included in this tip sheet.
Few questions have captivated humankind more than the origin of life on Earth. How did the first living cells come to exist? How did these early protocells develop the structural membranes necessary for cells to thrive and assemble into complex organisms? New research from UC San Diego has uncovered a plausible explanation involving the reaction between two simple molecules.
A pivotal study has uncovered a genetic defense mechanism in lily plants against Botrytis cinerea, the fungus behind gray mold disease. Central to this defense is LlHSFA4, a transcription factor that, when activated, initiates a robust response against the pathogen. This discovery could transform strategies for protecting horticultural crops from severe fungal infections.
A recent study in Ficus hispida genomics has unlocked the genetic mechanisms driving this fig tree鈥檚 unique reproductive system. The fully sequenced genome, a first of its kind for Ficus, reveals critical insights into how sex is determined in these plants鈥攁 factor crucial to their survival and ecological role. This research is a milestone for advancing the understanding of dioecy in plants and could open new doors for plant breeding and ecosystem management.
At a glance: A new study in mice explains how even a single faulty copy of the BRCA1 gene can fuel tumor growth. The findings suggest the dominant 鈥渢wo-hit鈥� hypothesis of cancer development may not tell the full story behind how cancer arises. Study identifies cellular changes that prime cancer-related genes for action and render cells vulnerable to tumor growth. The findings can inform new treatments that block the priming effect to prevent breast cancer formation.
Scientists at St. Jude Children鈥檚 Research Hospital have uncovered a previously unrecognized tumor suppression mechanism through the study of condensates and ribosome formation.
Pioneering research has unlocked new understanding of the genetic intricacies within the octoploid strawberry, focusing on the interplay and divergence among its four ancestral subgenomes. This work provides critical insights into the genetic foundations that govern key agronomic traits such as flavor, fruit quality, and disease resistance, essential for shaping the future of strawberry breeding programs.
The University of Texas MD Anderson Cancer Center today announced the launch of its Institute for Cell Therapy Discovery & Innovation, which will build upon longstanding MD Anderson clinical and research expertise to lead the world in developing and advancing impactful cell therapies for patients in need.
Some animal species seem to possess extraordinary regenerative abilities. How do they do it? And could we learn from them to defy the grim reaper ourselves?
Capsaicin, the compound in chili peppers which gives them their spicy taste, may become a source of new, natural drugs for the hard-to-treat Mesothelioma type of cancer.
Las c茅lulas madre cultivadas en microgravedad a bordo de la Estaci贸n Espacial Internacional (EEI) poseen cualidades 煤nicas que alg煤n d铆a podr谩n ayudar a potenciar las nuevas bioterapias y curar enfermedades complejas, seg煤n dos investigadores de Mayo Clinic. El an谩lisis de la investigaci贸n por el investigador Fay Abdul Ghani y por el Dr. y Ph.D. Abba Zubair, publicado en NPJ Microgravity ha hallado que la microgravidad puede fortalecer el potencial regenerativo de las c茅lulas. El Dr. Zubair es especialista en medicina de laboratorio y director m茅dico del Centro de Bioterapias Regenerativas en Mayo Clinic, Florida. Abdul Ghani es tecn贸logo de investigaci贸n en Mayo Clinic. La microgravedad es la ausencia o gravedad cercana a cero.
A new method developed by University of Michigan researchers creates images that are worth many gigabytes of data, which could revolutionize the way biologists study gene expression.
October is Breast Cancer Awareness Month, and fittingly, University of New Mexico Comprehensive Cancer Center biologist Curt Hines, PhD, has published a pair of papers that comprehensively describe the twelve major types of cells in the human breast.
A new analysis led by researchers at Washington University School of Medicine in St. Louis has revealed detailed 3D maps of the internal structures of multiple tumor types. These cancer atlases reveal how different tumor cells 鈥� and the cells of a tumor鈥檚 surrounding environment 鈥� are organized, in 3D, and how that organization changes when a tumor spreads to other organs. The detailed findings offer scientists valuable blueprints of tumors that could lead to new approaches to therapy and spark a new era in the field of cancer biology, according to the researchers.
Researchers at the Icahn School of Medicine at Mount Sinai have discovered a way that ovarian cancer tumors manipulate their environment to resist immunotherapy and identified a drug target that could overcome that resistance. The study, published in the October 30 online issue of Cell used a cutting-edge spatial genomics technology and preclinical animal models, with tumor specimens from ovarian cancer patients further validating the findings. They found that ovarian cancer cells produce a molecule called Interleukin-4 (IL-4), which is typically associated with asthma and the skin condition eczema, also known as atopic dermatitis. The study went on to find that the cancer cells used IL-4 to create a protective environment that kept away killer immune cells, making the tumors resistant to immunotherapy. A drug, dupilumab, which blocks IL-4鈥檚 activity, has been approved by the Food and Drug Administration (FDA) and is already used to treat asthma and eczema. This new study suggests dupi
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