Their research suggests that until now the scale of coeliac disease among UK children has been under-estimated. Currently, fewer than one in 2,500 children is treated for the disease, but the study of children in Bristol has shown that it probably affects one child in 100, although most have no overt symptoms.
Significantly, the figures appear to indicate that coeliac disease, an intolerance to gluten, is triggered in childhood, although the symptoms might not appear until years later.
The extent of the condition is revealed by the Children of the 90s project, also known as the Avon Longitudinal Study of Parents and Children, based at the University of Bristol.
Dr Polly Bingley from the University of Bristol analysed blood samples collected from 5,470 children at the age of 7 1芒聛鈥�2, looking for antibodies which are markers for the disease. While 54 of the children tested positive, only four were on a gluten-free diet. She found:
- 1% of children had antibodies to tissue transglutaminase and endomysial antibodies, indicating a very high probability of undetected or subclinical coeliac disease- Girls were more than twice as likely as boys to have these antibodies- On average, the children who had these antibodies were 2.7 cm shorter and 1 Kg lighter than those who did not.
Dr Bingley said: "The children had only mild, if any, gastrointestinal symptoms. A striking observation was that they were shorter and lighter than antibody negative children matched for date and place of birth. This equates to about 9 months' growth and weight gain in an average child around this age. "
It is already known that 1 per cent of the UK's adult population have coeliac disease. The illness is often represented as an iceberg since only a minority of affected individuals are diagnosed.
People with the condition suffer inflammation of the gastrointestinal tract, caused by a protein present in wheat and some other cereals which damages the lining of the small intestine and reduces the ability of the gut to absorb adequate nutrients from food.
The symptoms vary widely; many people show no outward sign of the condition, some complain of tiredness and anaemia, while others experience weight loss and obvious gastrointestinal symptoms such as diarrhoea. Coeliac UK, who funded the research, say the intestine generally returns to normal with a strict gluten-free diet.
Dr Bingley says: "We have found that the frequency of coeliac disease at age 7 is the same as that we find in adults in this country, suggesting that the condition starts in childhood, even in individuals in whom it is diagnosed late in life. They don't suddenly develop coeliac disease " they've probably had it for years before it is eventually detected."
The latest results will help guide future research into possible causes of coeliac disease, looking at infant foods and influences on the baby in the womb, and will pave the way for better treatment or prevention of the disease.
Undiagnosed coeliac disease at age seven: a population-based prospective birth cohort study. Polly J Bingley, Alistair JK Williams, Alastair J Norcross, D Joe Unsworth, Robert J Lock, Andrew R Ness, Richard W Jones and the ALSPAC study team. British Medical Journal
NOTES
ALSPAC The Avon Longitudinal Study of Parents and Children (also known as Children of the 90s) is a unique ongoing research project based in the University of Bristol. It enrolled 14,000 mothers during pregnancy in 1991-2 and has followed the children and parents in minute detail ever since.
The early stages of coeliac disease are poorly understood. Gluten is usually introduced to the diet soon after weaning, but the majority of cases are not diagnosed until adult life. The age at which the diseases process begins is unknown.
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