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News — Learning a complex skilled movement like tying your shoes or playing an instrument takes practice. After repeating the same movements over and over, people often develop a formulaic way of performing the task, and may not even have to think about it anymore. Although we accomplish such repetitive tasks every day, little is known about how the brain learns, repeats, and perfects them.

Now, a researcher at the University of Maryland School of Medicine (UMSOM), and his colleagues at Harvard University, have shown in rats how several brain regions need to work together to acquire a skill and replicate it flawlessly with each rat adding their own personal flair in the form of a “dance.”

 Their study was published on February 25, 2022, in .

“Besides following our basic curiosity to figure out how the brain works and how we learn movements, our work has many direct applications. Understanding the conditions under which healthy brains learn informs how people should train for highly skilled activities like certain sports,” said Assistant Professor of Pharmacology at the University of Maryland School of Medicine. “More importantly, one day hopefully the insights gathered from this basic research program will help people with brain damage or diseases that affect movements.”

The research team trains rats to study how their brains learn and perform new skills. In these experiments, the rats learn to press a lever in a specific way to get a drink of water.

“During the learning process, they develop a little dance, and each rat comes up with their own choreography,” said Dr. Wolff. “After they have perfected their technique, they continue to do whatever worked for them when learning: one animal will scratch the wall, another will tap their foot, and another sticks out their tongue, while simultaneously pressing the lever.”

These dances are similar to the superstitious movements that baseball pitchers perform every time they wind up to pitch the ball, like tugging on the brim of their hat or scratching the sand with their foot.

In a former study, the team showed that when the researchers damaged the motor cortex — part of the outermost layer of the brain — the rats could not learn their little dances. Yet, once they had learned their dance to execute the task, they could perform it just fine without this brain region. In a different study, the researchers found another brain area essential for learning the task — the basal ganglia, a region deep in the brain. This region is also affected in Parkinson’s disease.

In their newest study, the researchers put the pieces together, asking whether the motor cortex teaches the basal ganglia to produce the new skill. They used viruses to shut down the connection between the two brain areas. As the researchers expected, they found without the motor cortex teaching the basal ganglia, the rats could no longer develop any of their dances. 

The researchers then wanted to see if the basal ganglia also worked together with other brain regions to execute the learned skill. They focused on another region deep in the brain, which also has strong connections to the basal ganglia — the thalamus.

When the researchers now disrupted the connection from the thalamus to the basal ganglia with their virus tool, the rats still pressed the lever, but they completely lost their idiosyncratic learned ‘dances.’ The rats fell back to repeatedly swatting at the lever, just as they all did when they first started to learn the task. Dr. Wolff explained that these simple movements could be produced by other, more basic parts of the brain, like the brainstem.

“This work helps to reveal the logic of how individual brain regions work together to control skill learning and execution, a first step in our quest to help treat patients with motor movement disorders like Parkinson’s disease, and injuries from trauma or stroke to the motor-controlling parts of the brain,” said Executive Vice President for Medical Affairs, University of Maryland Baltimore, and the John Z. and Akiko K. Bowers Distinguished Professor at the University of Maryland School of Medicine.

Other authors on the study are Raymond Ko, PhD, and Bence Ölveczky, PhD, of Harvard University.

This study was supported by the National Institute of Neurological Disorders and Stroke (R01-NS099323-01, R01-NS105349), a European Molecular Biology Organization postdoctoral fellowship (ALTF1561-2013), and a Human Frontier Science Program postdoctoral fellowship (LT 000514/2014).

About the University of Maryland School of Medicine

Now in its third century, the University of Maryland School of Medicine was chartered in 1807 as the first public medical school in the United States. It continues today as one of the fastest growing, top-tier biomedical research enterprises in the world – with 46 academic departments, centers, institutes, and programs, and a faculty of more than 3,000 physicians, scientists, and allied health professionals, including members of the National Academy of Medicine and the National Academy of Sciences, and a distinguished two-time winner of the Albert E. Lasker Award in Medical Research. With an operating budget of more than $1.2 billion, the School of Medicine works closely in partnership with the University of Maryland Medical Center and Medical System to provide research-intensive, academic and clinically based care for nearly 2 million patients each year. The School of Medicine has nearly $600 million in extramural funding, with most of its academic departments highly ranked among all medical schools in the nation in research funding. As one of the seven professional schools that make up the University of Maryland, Baltimore campus, the School of Medicine has a total population of nearly 9,000 faculty and staff, including 2,500 students, trainees, residents, and fellows. The combined School of Medicine and Medical System (“University of Maryland Medicine”) has an annual budget of over $6 billion and an economic impact of nearly $20 billion on the state and local community. The School of Medicine, which ranks as the 8th highest among public medical schools in research productivity (according to the Association of American Medical Colleges profile) is an innovator in translational medicine, with 606 active patents and 52 start-up companies. In the latest U.S. 麻豆传媒 & World Report ranking of the Best Medical Schools, published in 2021, the UM School of Medicine is ranked #9 among the 92 public medical schools in the U.S., and in the top 15 percent (#27) of all 192 public and private U.S. medical schools.  The School of Medicine works locally, nationally, and globally, with research and treatment facilities in 36 countries around the world. Visit