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"Gulf War deployment continues to be strongly associated with increased MSI, affecting a considerable proportion of Gulf War veterans," write Stella M. Gwini and colleagues of Monash University, Melbourne, Australia. Multisymptom illness refers to chronic, unexplained symptoms affecting several body systems, such as fatigue, mood or cognitive (thinking) problems, and joint and muscle pain.

The researchers analyzed data from seven previous studies evaluating the prevalence of MSI among veterans of the 1990-91 Gulf War as well as the Afghanistan and Iraq Wars. In addition to including some more recent, higher-quality studies, the review added an Australian study to previous data from the United States and the United Kingdom.

Although estimates varied widely, MSI prevalence was substantially higher in Gulf War veterans: 26 to 65 percent, compared with 12 to 37 percent in Iraq/Afghanistan War veterans. On pooled data analysis, the odds of MSI were 2.5 times higher in Gulf War veterans versus other military groups.The odds were slightly lower in higher-quality studies. Veterans who were deployed to Iraq or Afghanistan were more likely to have MSI than nondeployed personnel—but their risk was still not as high as in deployed Gulf War veterans.

The study provides "updated and more robust estimates" of the risk of MSI in Gulf War veterans, compared to other military personnel. Ms. Gwini and coauthors conclude that their results "highlight the continuing problem and magnitude of MSI in Gulf War veterans, calling for ongoing awareness of the need for timely health assessments and health care."

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About the Author Ms. Gwini may be contacted for interviews at stella.gwini(at)monash.edu

About ACOEMACOEM (), an international society of 4,500 occupational physicians and other health care professionals, provides leadership to promote optimal health and safety of workers, workplaces, and environments.

About Journal of Occupational and Environmental MedicineThe Journal of Occupational and Environmental Medicine () is the official journal of the American College of Occupational and Environmental Medicine. Edited to serve as a guide for physicians, nurses, and researchers, the clinically oriented research articles are an excellent source for new ideas, concepts, techniques, and procedures that can be readily applied in the industrial or commercial employment setting.