Nov. 25, 2024
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How race impacts patients’ response to cancer immunotherapy
First large-scale analysis finds immune checkpoint inhibitors are equally effective in Black, white patients; Black patients have fewer side effects
ANN ARBOR, Michigan — Clinical trials testing cancer immunotherapies significantly under-represented Black patients. So while these treatments have resulted in dramatically improved outcomes for some patients, researchers from the University of Michigan wanted to understand whether that success holds true for patients who are Black.
Researchers pulled electronic medical record data from 26,398 patients receiving immune checkpoint inhibitors through the Veteran Health Administration in 2020-2023. The cohort was comprised of 81% white patients and 19% Black patients. The study was based on data from the . Patients were treated with one or a combination of immune checkpoint inhibitors for any of the nearly 20 cancer types for which these treatments are FDA-approved.
The study, published in The Lancet Oncology, found . Black patients stayed on the treatment longer than white patients and experienced fewer severe side effects, including lower risk of colitis or thyroid disorders.
“Despite widespread use of immune checkpoint inhibitors in racially diverse populations, studies have not looked at the efficacy and safety of these drugs in large groups of non-white patients. While we found no evidence for lower efficacy of immunotherapy among Black patients, our study raises crucial questions about why Black patients had fewer immune-related side effects than white patients,” said senior study author Alex K. Bryant, M.D., M.A.S., assistant professor of radiation oncology at Michigan Medicine.
The authors urge prospective validation studies that represent all races and sexes are needed to understand these differences.
Additional authors: Sean Miller, Ralph Jiang, Matthew Schipper, Lars G. Fritsche, Garth Strohbehn, Beth Wallace, Daria Brinzevich, Virginia Falvello, Benjamin H. McMahon, Rafael Zamora-Resendiz, Nithya Ramnath, Xin Dai, Kamya Sankar, Donna M. Edwards, Steven G. Allen, Shinjae Yoo, Silvia Crivelli, Michael D. Green
Funding for this work is from LUNGevity, Million Veterans Program grant MVP064, VA Office of Research and Development grant CX002430
Disclosure: None
Paper cited: The Lancet Oncology. DOI: 10.1016.S1470-2045(24)00528-X
Resources:
University of Michigan Rogel Cancer Center,
Michigan Medicine Cancer AnswerLine, 800-865-1125
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