New Study Shows that Chronic Neurodegeneration can be Prevented after Traumatic Brain Injury

Credit: UH / CWRU

鈥淏rief P110 treatment during the acute time period after TBI permanently normalized mitochondrial fission / fusion and prevented subsequent harm to the brain, including oxidative damage, blood-brain barrier deterioration, axonal degeneration, and cognitive impairment, 17 months later. This is equivalent to many decades in people,鈥� explained Andrew A. Pieper, MD, PhD, senior author of the study and Director of the Brain Health Medicines Center of the Harrington Discovery Institute at UH.

« New Study Shows that Chronic Neurodegeneration can be Prevented after Traumatic Brain Injury

Credit: UH / CWRU

鈥淲e started with the hypothesis that TBI might pathologically impair the balance of mitochondrial fission and fusion,鈥� explained Preethy S. Sridharan, PhD, lead author of the study. 鈥淭he normal homeostatic balance of mitochondrial fission and fusion is how mitochondria consistently produce enough energy for the cell while also sequestering and disposing damaged parts. Given the very high energy demands of the brain, this is particularly important for brain health across our lifespan.鈥�

« New Study Shows that Chronic Neurodegeneration can be Prevented after Traumatic Brain Injury

Credit: UH / CWRU

鈥淣ext steps in the basic science research, on the other hand, involve further utilization of this model to yield additional new insights into understanding the pathophysiology and treatment opportunities for this important problem,鈥� explained Xin Qi, PhD, the Jeanette M. and Joseph S. Silber Professor of Brain Sciences in the CWRU Department of Physiology and Biophysics and Co-Director of the CWRU Center for Mitochondrial Research and Therapeutics.

« New Study Shows that Chronic Neurodegeneration can be Prevented after Traumatic Brain Injury

麻豆传媒

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