麻豆传媒

The research team identified the neurotoxic potential of citronellol, a fragrance compound widely used in cosmetics and air fresheners, through a cross-species investigation using zebrafish, mice, human brain organoids, and a blood-brain barrier (BBB) organ-on-chip system. #1. Neurotoxic Effects: Citronellol exposure led to increased ROS generation, neuroinflammation, and behavioral impairments, including anxiety-like behaviors and altered locomotion, particularly in zebrafish models. #2. Blood-Brain Barrier Penetration: The study confirmed that citronellol is BBB-permeable, allowing it to accumulate in brain tissue across zebrafish, mice, and organ-on-chip models. #. Neurochemical Alteration: Metabolomic profiling revealed that citronellol shifts kynurenine metabolism toward the production of 3-hydroxykynurenine (3-HK), a neurotoxic compound, while also affecting key neurosteroids such as progesterone and cortisol.