麻豆传媒

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New research from Memorial Sloan Kettering Cancer Center (MSK) provides a clearer understanding of glioblastoma heterogeneity to aid development of new therapies; sheds light on mechanisms of cellular plasticity; presents a new imaging technique that could improve the diagnosis of brain diseases by revealing how different parts of the brain are metabolizing nutrients; describes a new method to aid the study of rare but influential cell populations; and identifies a potential treatment for malignant peripheral nerve sheath tumors.

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A new study from McMaster University, in collaboration with community partners and researchers from Duke University, Oxford University, and Mahidol University, shows that screenings of a locally-produced narrative film about parenting led to a significant reduction in physical violence against children.

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In a study that could transform agricultural pest management, researchers have uncovered the robust insect resistance mechanisms of Solanum habrochaites, a wild tomato species. By unraveling the genetic and metabolic intricacies of the phenylpropanoid biosynthesis pathway, the study opens new avenues for breeding cultivated tomatoes with enhanced pest resistance. The findings hold the potential to reduce dependency on chemical pesticides, addressing mounting concerns over pesticide resistance and environmental harm.

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In the age of rapid advancements in omics technologies, the challenge of visualizing diverse and complex biological datasets has reached a critical point. Enter DataColor, a revolutionary software solution designed to illuminate hidden insights within these intricate datasets.

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Current first-line treatment for advanced clear-cell renal cell carcinoma includes anti-PD1 or anti-PD-L1 immunotherapy in combination with a CTLA-4 inhibitor or a VEGF tyrosine kinase inhibitor such as cabozantanib. These options have improved outcomes in patients, however not all patients respond, and some responses do not last. This study鈥檚 results suggest that further investigation of this novel combination as first-line therapy option is warranted.

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Bone regeneration research has taken a significant leap forward with the discovery of a crucial mechanism that could transform treatments for bone disorders. Scientists have identified how Discoidin Domain Receptor 2 (DDR2) enhances Bone Morphogenetic Protein (BMP)-dependent bone regeneration while mitigating the risk of heterotopic ossification (HO), offering promising therapeutic opportunities. This breakthrough sheds light on how DDR2 regulates BMP activity, paving the way for safer and more effective interventions in bone repair and related conditions.

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Qigong, a traditional Chinese practice combining gentle movements, breathing, and meditation, was assessed for its impact on biopsychosocial outcomes on veterans with chronic low back pain. The study measured pain intensity, disability, pain interference, sleep disturbance, PTSD, depression, anxiety, positive affect, and social roles. Findings showed significant improvements in pain-related outcomes and sleep disturbance in the qigong group compared to the control group. The study also found a significant connection between biological factors, such as inflammation markers, and psychosocial outcomes.

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Cutting-edge fluorescent cholesterol probes now enable scientists to visualize cholesterol movement and distribution in live cells with unprecedented detail. By combining computer simulations with live-cell imaging, researchers have uncovered how different probe designs influence cholesterol probe behavior. These probes could reveal how cholesterol imbalances drive Alzheimer鈥檚 and other neurodegenerative disorders, aiding drug development to modulate lipid activity and potentially offering new treatments or prevention strategies.

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Scientists have uncovered how sundews, Charles Darwin鈥檚 favourite plant, become more carnivorous in certain habitats. Researchers from Loughborough and Gloucester universities found that they alter the density of their leaf tentacles and the uptake of nitrogen from prey to thrive in different microhabitats, such as mounds and hollows, within peatland ecosystems.