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HIV Protein Switch May Help Virus Squeeze into Host Cell Nucleus

How the HIV inserts its capsid into the host cell鈥檚 nuclear pore is a puzzle and a therapeutic target. Simulations on the Pittsburgh Supercomputing Center鈥檚 Bridges-2 system by a University of Pittsburgh team revealed how changes in the shape of...
11-Feb-2025 6:50 PM EST Add to Favorites

Large-Scale Evolution Simulations on PSC鈥檚 Neocortex Tackle Questions about Hypermutator Evolution

In real life, mutants can arise when their DNA changes to give them an advantage over the rest of the population. A team from the University of Michigan has used simulations on the Pittsburgh Supercomputing Center鈥檚 Neocortex system to find out...
5-Feb-2025 7:10 PM EST Add to Favorites

Pittsburgh Supercomputing Center Interns to Represent U.S. at International Student Competition

A team of interns from the Pittsburgh Supercomputing Center has been selected to represent the U.S. next year at a student competition at the International Supercomputing Conference (ISC25) in Hamburg, Germany, in June 2025.
18-Dec-2024 9:45 PM EST Add to Favorites

Parkinson鈥檚 Research, Evolution of Vocalization, AI Training Tool, and National AI Collaboration Underlie Four HPCwire Awards to PSC

Parkinson鈥檚 research, a genetic commonality among very different species that learn how to vocalize, an AI-based water treatment training simulator, and a national AI collaboration underlie four annual HPCwire Awards won by PSC this year.
14-Nov-2024 3:30 PM EST Add to Favorites

Enhancing Hurricane Forecasts: A Game-Changer in Lessening Catastrophic Impacts

A team from the University of Houston found that, when they reduced estimates of atmospheric friction of storms, their predictions on PSC鈥檚 Bridges-2 improved markedly over standard storm predictions. This advancement promises better planning to...
26-Sep-2024 1:05 PM EDT Add to Favorites

$4.9-Million NSF Award Funds Major Enhancement to Bridges-2 System

$4.9 million from the NSF has funded an upgrade to PSC鈥檚 flagship Bridges-2 supercomputer. The grant has allowed the center to add late-model powerful NVIDIA H100 GPUs to the system, further enhancing its ability to support research in and...
13-Aug-2024 9:00 AM EDT Add to Favorites

$3.15 million from NIH to Fund Operation of Third-Generation Anton Supercomputer at Pittsburgh Supercomputing Center

A third-generation Anton supercomputer, developed by D. E. Shaw Research, will soon arrive at the Pittsburgh Supercomputing Center. A $3.15-million, five-year award from the National Institutes of Health will fund the system's operations, making it...
5-Aug-2024 12:05 PM EDT Add to Favorites

Bridges-2 Helps Retrain AIs to Avoid Creating Offensive Pictures for Specific Cultures

A Carnegie Mellon University-led team has used the Pittsburgh Supercomputing Center鈥檚 Bridges-2 system and input from different cultures to develop an effective fine-tuning approach for retraining a popular image generator so that it can generate...
3-Jun-2024 10:05 AM EDT Add to Favorites


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The Pittsburgh Supercomputing Center is a joint computational research center with Carnegie Mellon University and the University of Pittsburgh. Established in 1986, PSC is supported by several federal agencies and the Commonwealth of Pennsylvania, and is a leading partner in ACCESS, the National Science Foundation cyber infrastructure program.

PSC provides university, government and industrial researchers with access to several of the most powerful systems for high-performance computing, communications and data storage available to scientists and engineers nationwide for unclassified research. PSC advances the state of the art in high-performance computing, communications and data analytics and offers a flexible environment for solving the largest and most challenging problems in computational science.

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