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Delicate Balancing Act Determines How Many Genome Gateways Form in Cells

As warehouses go, nuclei are more like libraries than bank vaults. Too many cellular components need access to the genome to lock it down like Fort Knox. Instead, large groupings of more than 1,000 individual protein molecules called nuclear pore...
26-Mar-2025 8:25 PM EDT Add to Favorites

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Engineering Antibodies with a Novel Fusion Protein

Even with significant expansion in the global market for antibodies used in clinical care and research, scientists recognize that there is still untapped potential for finding new antibodies. Many proteins group together in what are called protein...
25-Mar-2025 7:45 PM EDT Add to Favorites

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Cellular Circuit Controls How DNA Damage Is Repaired, Affecting Risk of Disease as We Age

Scientists at Sanford Burnham Prebys and collaborators across the country published findings March 5, 2025, in Nature Communications showing that the mitochondria powering our cells also control the ability of a DNA repair protein to suppress the...
13-Mar-2025 8:05 PM EDT Add to Favorites

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Drug Building Blocks Pave Path to New Sepsis Treatments

The immune system typically can ramp up the body鈥檚 defenses to clear out an invading threat without issue. Glitches can happen, however, with sepsis occurring when the mustered army of cells also attacks the body鈥檚 own tissues and organs as if...
11-Mar-2025 8:25 PM EDT Add to Favorites

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Making Heart Scar Tissue a Nonissue

New Sanford Burnham Prebys scientist Ahmed Mahmoud, PhD, and his team focus on how to repair adult hearts by restoring the regenerative powers they once possessed early in development. He wants to advance the discoveries he has made in regenerating...
7-Mar-2025 7:05 PM EST Add to Favorites

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Future Drugs May Snap Supply Chain Fueling Breast Cancer

Cancer cells have an insatiable appetite for energy as they multiply more rapidly than normal cells. Greedy cancer cells hijack various cellular functions to find and exploit energy and other resources, including a group of enzymes that help normal...
5-Mar-2025 8:00 PM EST Add to Favorites

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Gene Therapy May Be 鈥淥ne Shot Stop鈥� for Rare Bone Disease

For the last 10 years, the only effective treatment for hypophosphatasia (HPP) has been an enzyme replacement therapy that must be delivered by injection three-to-six times each week. Currently, patients are treated with injections of asfotase alfa,...
3-Feb-2025 9:10 PM EST Add to Favorites

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Leona M. Flores, PhD, Named Vice President of Research Operations at Sanford Burnham Prebys

Leona M. Flores, PhD, has been named vice president of research operations at Sanford Burnham Prebys. She will elevate the research capacity of the institute by working with faculty and other scientists to ensure successful execution of research...
8-Jan-2025 7:20 PM EST Add to Favorites


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Xueqin Sun seeks to illuminate the underlying causes of cancer

As a new assistant professor at Sanford Burnham Prebys faculty, Sun seeks to better understand the genetic and epigenetic underpinnings of cancers, using genome editing technologies, animal and patient-derived models, and other tools to develop more...
13-Mar-2024 9:05 AM EDT

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Sanjeev Ranade wants to get to the heart of congenital disease

Sanjeev S. Ranade, Ph.D., who joined the faculty of Sanford Burnham Prebys this month as an assistant professor in the Development, Aging and Regeneration program, studies how proteins called transcription factors (TFs) specifically control the...
22-Jan-2024 6:00 AM EST

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When T cells and macrophages talk, Kelly Kersten listens

Kelly Kersten, Ph.D., who joined Sanford Burnham Prebys this month as an assistant professor in the Cancer Metabolism and Microenvironment program, studies the interactions between immune cells and their microenvironment to better understand how...
17-Jan-2024 2:05 PM EST

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Shengjie Feng channels the powers of cryogenic electron microscopy

Shengjie Feng, Ph.D. is an expert in cryo-electron microscopy, a Nobel Prize-winning imaging technology capable of creating stop-action movies of proteins and other biomolecules jostling and connecting with each other while mitochondria and other...
16-Jan-2024 12:05 PM EST

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Fighting Against Triple-Negative Breast Cancer

2-Oct-2017 8:00 AM EDT

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Brrrr...it's WINTER. Can Being Cold Really Help You Burn Calories and Slim Down? An #SBP Researcher Weighs In

31-Jan-2017 2:05 PM EST

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Could Fake Sugar Cause Real Problems with Your Metabolism? An @SBPdiscovery Researcher Wants to Find Out

7-Nov-2016 8:00 AM EST

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To Treat Breast Cancer, Give It a Lifeline

19-Oct-2016 12:05 PM EDT

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About

Sanford Burnham Prebys is an independent biomedical research institute dedicated to understanding human biology and disease and advancing scientific discoveries to improve human health. For over 40 years, our research has produced breakthroughs in cancer, neuroscience, immunology and children鈥檚 diseases, and is anchored by our NCI-designated cancer center and advanced drug discovery capabilities. For more information, visit us at SBPdiscovery.org or on Facebook at facebook.com/SBPdiscovery and on Twitter @SBPdiscovery.

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