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Sumit Chanda, Ph.D

Director and Professor Immunity and Pathogenesis Program

Sanford Burnham Prebys

Immunity, Infectious Disease, Inflammatory Disease, Pathogenesis, Research

Sumit Chanda earned his Ph.D. from Stanford University in 2001, and received his post-doctoral training at the Genomics Institute of the Novartis Research Foundation (GNF). He subsequently transitioned to a Group Leader position, and established his research group in the Division of Cellular Genomics at GNF. In 2007, he joined the Infectious and Inflammatory Disease Center at Sanford-Burnham Medical Research Institute as an Associate Professor. Dr. Chanda also holds an Adjunct Professor appointment at the Salk Institute for Biological Studies, as well as a Visiting Scientist position at the Genomics Institute of the Novartis Research Foundation.

Bacteria, Bacterial Resistance, Biochemistry, Biologics, Biosecurity, Biotechnology, Genomics, host-pathogen interactions, Infectious Diesease, Microbiology, Microbiome, one health, Pathogenesis, Protein Engineering, Toxins

 

Brenda Anne Wilson is a Professor of microbiology in the School of Molecular & Cellular Biology at the University of Illinois Urbana-Champaign. She also is the Inaugural Professor of Biomedical and Translational Sciences in the Carle Illinois College of Medicine, an adjunct professor of pathobiology in the College of Veterinary Medicine; and the Sandia Senior Faculty Fellow in the university's Office of the Vice Chancellor for Research and Innovation. 

Wilson is a fellow of the American Academy of Microbiology and a member of the AAM Selection Committee, and an American Society for Microbiology Distinguished Lecturer.

She was a DAAD graduate exchange Fellow in biochemistry at Ludwig-Maximilians Universität München, Germany. While earning her PhD at Johns Hopkins University, she was an AAUW doctoral fellow and studied antibiotic biosynthesis. She then undertook her NIH postdoctoral fellowship training in microbiology at Harvard Medical School, where she began her studies on bacterial protein toxins. Her first tenured faculty appointment was in biochemistry at Wright State University School of Medicine, Dayton, Ohio.

As inaugural leader of the Host-Microbe Systems Theme of the Woese Institute for Genomic Biology at the University of Illinois for 10 years, Wilson brought together faculty and scientists from multiple disciplines across campus, including microbiology, anthropology, animal sciences, engineering, and veterinary pathobiology to forge new areas of microbiome research. She served for 10 years on the executive committee of the Great Lakes Regional Center for Excellence in Biodefense and Emerging Infectious Diseases. As co-director of the University of Illinois Center for Zoonoses Research, she has promoted the One-Health Initiative and training of DVM students in research through summer training experiences. For nearly 20 years she has served as Biosecurity Leader of the Executive Committee of the University of Illinois Program in Arms Control, Domestic and International Security, where she has engaged events promoting scientific literacy and bridging the gap between scientists and educators, policy makers, government officials, and the public.

Wilson is currently president of the Champaign-Urbana Branch of the American Association for University Women, where she helps organize and convene community outreach events aimed at advancing equity and higher education opportunities for women and girls, particularly in STEM areas. As director for undergraduate education in the School of Molecular and Cellular Biology, she helps oversee the delivery of all academic, advising, and curricular aspects of the BS in MCB, BS in Biochemistry, BS in Neuroscience, and the forthcoming BS in MCB + Data Science undergraduate programs and the MS in MCB graduate programs. As the Sandia Senior Faculty Fellow in the Office of the Vice-Chancellor for Research and Innovation, she fosters, engages, and sustains research collaborations in STEM disciplines, including building workforce pipelines between scientists at the University of Illinois and the U.S. Department of Energy's national labs.

Research interests

Wilson’s research focuses on the host-microbe interface, bacterial pathogenesis and bacterial protein toxins, development of anti-toxin and toxin-based therapeutic biologics, comparative and functional genomic technologies and applications involving microbiomes and their roles in health and disease, climate change impacts on microbiomes, health, and disease transmission, and development of technologies and applications for detection and risk assessment of Dual Use Research of Concern (DURC) objects, publications, and activities. She has published over 150 scientific articles, chapters, and books, including the highly acclaimed textbook Bacterial Pathogenesis: A Molecular Approach (4th Edition, 2019, ASM Press/John Wiley) and the recent Revenge of the Microbes: How Bacterial Resistance is Undermining the Antibiotic Miracle (2nd Edition, 2023, ASM Press/John Wiley).

Education

BA (Biochemistry and German), Barnard College/Columbia University, 1981

Biochemistry Diplomarbeit (Post-baccalaureate Program), Deutscher Akademischer Austauschdienst (DAAD), Ludwig-Maximilians Universität, Munich, Germany, 1981-1982

M.S./Ph.D. (Chemistry), Johns Hopkins University, 1989

Postdoctoral (Microbiology and Molecular Genetics), Harvard Medical School, 1989-1993

Website

Gene Expression and Regulation, Genomics, Metabolism, Myotonic Dystrophy, Pathogenesis, RNA Biology, tissue development, Tissue Regeneration

Auinash (Nash) Kalsotra is a professor and Willam C. Rose Scholar of Biochemistry in the School of Molecular & Cellular Biology at the University of Illinois Urbana-Champaign. He also is an adjunct professor in the Division of Nutritional Sciences, Cancer Center@Illinois, and Carl R. Woese Institute for Genomic Biology. 

Kalsotra is a Chan Zuckerburg Biohub Chicago investigator, a Beckman Institute fellow, and an associate editor of the WIREs RNA journal (Wiley).

He received his undergraduate degree in pharmacy from the Birla Institute of Technology and Science, Pilani, India (1999). While earning his PhD at the University of Texas MD Anderson Cancer Center, he was a Harry S. and Isabel Cameron doctoral fellow and studied the role of cytochromes P450 in the progression and resolution of inflammation. During his postdoctoral work as a Myotonic Dystrophy Foundation fellow and an American Heart Association young investigator at Baylor College of Medicine, he began his studies on post-transcriptional gene regulation and RNA biology in human health and disease. Kalsotra started his independent research group in 2013.

He teaches MCB 354: The Biochemical and Physical Basis of Life, a course with large enrolments of over more than 400 students each academic yera. As a junior faculty mentor and advisor, he provides guidance and support to pre-tenured faculty in the School of Molecular and Cellular Biology.

As an active member of the RNA Society, Kalsotra has organized/chaired scientific sessions at various national and international meetings. He also serves as an expert reviewer for several funding agencies and journals. Additionally, as a steering committee member of the Rustbelt RNA community, he is involved in guiding RNA research in the Midwest, promoting long-term efforts to ensure the viability of the annual RRM conference, and fostering the professional development of students from smaller universities and predominantly undergraduate institutions.

Research interests

Kalsotra’s research interests are to uncover the biological function(s) of RNA in tissue development, regeneration, and disease. He is particularly interested in understanding:

  • how various RNA processing mechanisms integrate with transcriptional, translational, and metabolic programs to ensure normal tissue growth and function,
  • why misregulation of these mechanisms results in disease, and
  • whether they can be leveraged to prevent or reverse particular human disorders.

Recent work from the Kalsotra laboratory has resulted in many high-profile publications, e.g., Genes & Dev., J. Exp. Med, Genome Res., Dev. Cell, J. Clin. Invest., PNAS, Nature Struct. Mol. Biol., eLife, and Nature Commun. He has also published invited articles, including perspectives and opinions in Nature Reviews, Curr. Opin. Genet. Dev., Semin. Cell Dev. Biol. Kalsotra is regularly invited to present his research findings at major conferences, universities, and research centers. His research activities have been funded by grants from the National Institutes of Health, Department of Defense, Muscular Dystrophy Association, Chan Zuckerburg Initiative, March of Dimes, and American Heart Association.

 

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