Dilip joined the Danforth Center on November 1, 2001, the same day that our original building was inaugurated. “When I first came to the Danforth Center, I was suddenly working with PIs that studied plant cell biology, plant structural biology, plant biochemistry. It was really very exciting to have the opportunity to collaborate with them. It was extremely gratifying,” explains Dilip. Dilip’s lab studies how plants defend themselves against fungal diseases. The goal of their research is to discover new ways to enable plants to better protect themselves from fungal attacks. To do this, they research antifungal peptides that have the ability to kill pathogens. Once Dilip’s lab understands how a peptide eliminates a pathogen, his lab can then apply the peptides to make crops resistant to a specific disease. One of the fungal diseases that Dilip and his lab are researching is Gray Mold Disease, which causes multi-millions of US dollars in pre- and postharvest losses across the world. Gray mold is caused by a fungus Botrytis cinerea that can infect flowers, fruits, and vegetables. Dilip’s lab is working on technology that, when applied, could potentially control gray mold in multiple economically important plants. Dilip’s work also has significant implications for the future of food security. In agriculture, 15-20% of crops are lost each year because of the fungal diseases. By making plants more disease resistant, Dilip could reduce that statistic. For a smallholder farmer where each bushel is critical to feeding the community, reducing crop loss could drastically improve human health.
Peptyde Bio discovers, designs, and characterizes novel anti-microbial peptides (AMPs)
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Plastomics Inc., an agricultural biotech start-up developing the next generation of trait delivery technology, has been awarded a competitive grant from the United Soybean Board (USB) to develop disease resistant soybeans.
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“We are excited about the possibility of developing this class of peptides as a spray-on fungicide that would provide farmers with an environmentally friendly alternative to chemical fungicides for pre- and post-harvest management of fungal diseases,” said researcher Dilip Shah. “When applied to crops, the peptides will eventually break down to amino acids in the soil and be used by beneficial microbes as an energy source.”
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"Plant defensins exhibit potent antifungal activity against several economically important fungal pathogens and it is exciting to see a successful application of this technology for reducing the pre-harvest infection by Aspergillus and alleviating the burden of mycotxins in genetically modified groundnut. If deployed commercially, this technology has significant potential to contribute to food safety in the under-developed and developing countries where mycotoxin contamination of groundnut, maize, chili, and cottonseed pose a major threat to human and animal health," said Dilip Shah, Ph.D., principal investigator at the Danforth Plant Science Center.
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