Following successful Phase 1 clinical trials, the Toca regimen 鈥 a new immunotherapy for patients with recurrent brain cancer 鈥 has advanced to a Phase 3 study, which is currently underway. The trial is being conducted at 68 sites across the United States, Canada, Israel and South Korea, including at Overlook Medical Center鈥檚 Gerald J. Glasser Brain Tumor Center, one of three clinical trial sites in New Jersey. In this surgical study, patients are randomized to either standard of care treatment or the Toca regimen. Enrollment is expected to complete in this trial by the end of 2018.
Atlantic Health System is now enrolling patients in four pancreatic cancer clinical trials. Angela Alistar, MD, a nationally known expert on pancreatic cancer, is serving as national Principal Investigator (PI) on the first trial and as local PI on three other trials.
Researchers at Atlantic Sports Health found people using wearable fitness trackers mere more motivated when they had access to the information they provide, not just from wearing the device.
Dr. Alistar has pioneered the use of CPI-613庐 (devimistat), a unique first-in-class treatment for locally advanced or metastatic pancreatic cancer, in combination with two chemotherapy drugs. Devimistat uniquely targets enzymes involved in cancer cell metabolism, against pancreatic cancer. The study鈥檚 efficacy data suggest devimistat has synergy with chemotherapy.The current study was funded by the drug鈥檚 manufacturer, New Jersey-based Rafael Pharmaceuticals and by Atlantic Health System.
A new type of immunotherapy treatment for metastatic non-small cell lung cancer (NSCLC) is being tested by Missak Haigentz, Jr., MD, medical director of hematology and oncology for Atlantic Health System. Early results appear promising in this phase 1/2 clinical trial of ADXS-503 being developed by Advaxis, Inc., a new type of cancer therapy which targets 鈥渉otspot鈥 mutations that commonly occur in specific cancer types, both by itself and in combination with immunotherapy Keytruda庐 (pembrolizumab), which is commonly used to treat this type of lung cancer. Dr. Haigentz and colleagues published early results of this study in conjunction with ASCO 2020, the world鈥檚 premier scientific meeting for clinical research in oncology.