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Released: 15-May-1999 12:00 AM EDT
Sex Differences Found in Proportions of Gray and White Matter in the Brain
Perelman School of Medicine at the University of Pennsylvania

Head size correlates statistically with intelligence, and men's heads, like their bodies, are bigger than women's. Men should be more intelligent than women - but they are not. Now, researchers report an explanation for the conundrum: Women have a higher proportion of gray matter - computational tissue - to cranial volume than men.

Released: 14-Jan-1999 12:00 AM EST
New COX-2 Inhibitors May Elevate Cardiovascular Risk
Perelman School of Medicine at the University of Pennsylvania

The so-called "super aspirins," or COX-2 inhibitors, may have a downside, one that could not have been detected in the clinical trials performed to date. A new study suggests that aspects of their action in the body may elevate the risk of heart attacks, strokes, and other adverse cardiovascular events.

5-Mar-1999 12:00 AM EST
Adjacent Sequences Tag Along with Mobile DNA Elements
Perelman School of Medicine at the University of Pennsylvania

In this age of molecular biology, scientists would like to know whether and how evolution operates at the molecular level in an organism's DNA. Now, in a new study, researchers have discovered a molecular mechanism that may be a significant driver of evolution in humans and other mammals.

24-Mar-1999 12:00 AM EST
Chemoembolization Effective for Liver Tumors
Perelman School of Medicine at the University of Pennsylvania

A Phase-II study performed by a team of researchers at the University of Pennsylvania Medical Center has found that a minimally invasive technique known as chemoembolization may double the survival time of adult patients with colon cancer that has spread to the liver.

30-Mar-1999 12:00 AM EST
New Gene May Play Important Role in Regulating HDL, the "Good" Cholesterol
Perelman School of Medicine at the University of Pennsylvania

Scientists have identified a new human gene that may figure prominently in the regulation of cholesterol levels in the body. When the gene was experimentally overexpressed in mice, levels of HDL cholesterol - the "good" cholesterol - dropped to nearly undetectable levels, a condition associated with high cardiovascular disease risk in humans.

8-Apr-1999 12:00 AM EDT
Alzheimer's Disease and Developmental Biology Linked Through Single Molecule
Perelman School of Medicine at the University of Pennsylvania

Researchers have uncovered a biochemical connection between presenilin, a molecule involved in the development of Alzheimer's disease, and another protein that controls crucial aspects of developmental biology.

Released: 29-Apr-1999 12:00 AM EDT
Mistakes in Protein Folding Caught by "Protein Cages"
Perelman School of Medicine at the University of Pennsylvania

Researchers at Penn Medical Center have discovered how proteins called chaperonins protect cells from harm by sequestering and unfolding misshapened proteins.

10-May-1999 12:00 AM EDT
Largest Protein Ever Created from Scratch
Perelman School of Medicine at the University of Pennsylvania

Researchers at the University of Pennsylvania Medical Center have created the largest protein from scratch, with both a stable and predictable shape. Applications include manufacturing entirely new polymers for industrial catalysts and creating new pharmaceuticals.

Released: 13-May-1999 12:00 AM EDT
New Class of Synthetic Capsules Mimics Cells
Perelman School of Medicine at the University of Pennsylvania

Bioengineers at the University of Pennsylvania have designed an artificial capsule that imitates many of the qualities of natural cells, with has wide-ranging applications.

Released: 25-May-1999 12:00 AM EDT
Univ. of Pennsylvania Medical Ctr. Tip Sheet
Perelman School of Medicine at the University of Pennsylvania

1. Structure of HDL Cholesterol Determined 2. Cellular Implants Explored for Brain Trauma 3. Cardiovascular Phenomenon Explained After 150 Years


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