麻豆传媒

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Results of a new analysis of the Treating to New Targets (TNT) study show that intensive LDL cholesterol-lowering in patients with stable coronary heart disease whose systolic blood pressure was less than 140 mmHg reduced the risk of major cardiovascular events, by 42 percent.

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Results of a new analysis of the Treating to New Targets (TNT) study show that intensive low-density lipoprotein (LDL) cholesterol-lowering in patients with stable coronary heart disease (CHD) whose systolic blood pressure was less than 140 mmHg reduced the risk of major cardiovascular events, including heart attack, stroke and resuscitated cardiac arrest, by 42 percent compared with less intensive LDL lowering and uncontrolled blood pressure of 140 mmHg or higher.

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In a journal article released August 1 students and faculty at UMDNJ-Robert Wood Johnson Medical School discuss the success of a service learning project created and operated by medical students in 2004 to address access to healthcare for New Brunswick's uninsured residents.

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Researchers at UMDNJ-Robert Wood Johnson Medical School have identified the protein MG53, as a key initiator of membrane repair in damaged tissue. The study, released today in Nature Cell Biology, is the first to specifically pinpoint a protein responsible for promoting cell repair.

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International research collaborators have identified a new family of proteins, TPC2 (two-pore channels), that facilitates calcium signaling from specialized subcellular organelles. The study, to be published April 22 in Nature, is the first to isolate TPC2 as a channel that binds to NAADP, a second-signaling messenger, resulting in the release of calcium from intracellular stores.

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Researchers at UMDNJ-Robert Wood Johnson Medical School are one step closer to determining how human cells can be protected against the affects of age-related neurodegeneration including Alzheimer's and Parkinson's disease. The findings, published this past month in Nature Neuroscience, link the oxidation of potassium channels, which control a variety of cell functions and are essential to neuronal function, to the loss of neuronal function in aging.

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Researchers at UMDNJ-Robert Wood Johnson Medical School are a step closer to treating, and perhaps preventing, muscle damage caused by disease and aging. In their study, published in the June issue of Journal of Biological Chemistry, the scientists have linked the newly discovered protein MG53 to a pathway that repairs human muscle tissue along with the proteins caveolin-3 (Cav3) and dysferlin.

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A team of researchers have identified elevated serum levels of the pesticide beta-hexachlorocyclohexane in patients with Parkinson's disease, indicating that exposure to a specific pesticide may contribute to the development of the disease.

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DNA replication is a basic function of living organisms, allowing cells to divide and multiply, all while maintaining the genetic code and proper function of the original cell. The process, or mechanism, by which this is accomplished presents many challenges as the double helical (coil-shaped) DNA divides into two strands that are duplicated by different methods, yet both strands complete the replication at the same time. New research by a team from UMDNJ-Robert Wood Johnson Medical School in conjunction with the University of Illinois and published in the Dec. 17 issue of Nature, has addressed this fundamental problem. The study identifies three essential ways the synthesis of the two strands is coordinated by enzymes, settling scientific deliberations on how the two DNA strands are copied in the same time span.

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Researchers at The Bristol-Myers Squibb Children鈥檚 Hospital (BMSCH) at Robert Wood Johnson University Hospital (RWJUH) and UMDNJ-Robert Wood Johnson Medical School (UMDNJ-RWJMS) have completed a study that pinpoints the period between 24 and 32 months of age as most effective time frame for parents to begin toilet training lessons with their children. Additionally, the study indicates that the timing appeared to matter more than the specific training method used.