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A collaborative effort led by The Burnham Institute's Gen-Sheng Feng has created a mouse with improved glucose tolerance and insulin activity in the liver, and generated new findings about insulin-signaling in the liver that could prove useful in understanding the pathogenesis of type 2 diabetes.
A Burnham Institute study has found that one of the cell's largest families of signaling molecules, called ephrins, which are known to regulate the development of nerve cells, also controls nerve cells' ability to engulf critical chemicals and proteins for learning and memory.
A Burnham Institute study has found that a protein known for its role in gene regulation has another important function, that of initiating DNA repair. The study points to new targets for treatment of cancer.
A collaborative team of scientists has identified inhibitors of the anthrax toxin, termed lethal factor that could be developed into an emergency treatment for exposure to inhalation anthrax.
A research team lead by the Burnham Institute has synthesized and tested a new series of inhibitors that can prevent the type of nerve cell injury and death associated with many neurodegenerative diseases and stroke.
A study reports that a cell-cycle checkpoint protein, known to be activated by an important class of anticancer drugs, may play crucial roles in both the hampering of therapeutic actions and aiding cancer cells to "recover"聺 and start dividing again after treatment with these drugs.
A collaboration has found that an antibody which binds to an unusual sugar molecule residing in the gut halts the inflammation seen in Crohn's disease and other intestinal inflammations. The antibody could prove to be a promising drug target for these common chronic intestinal disorders.
Researchers have provided detailed insights into the early formation of the heart. A team found that two proteins, called Robo and Slit, are required for normal development of the heart and that malfunction of either of these proteins severely impacts the heart's structure, resulting in congenital heart defects.
Researchers have shown that endocrine progenitor stem cells exist in the adult human pancreas, and they have demonstrated that these stem cells can be transformed into insulin-producing cells.
This data provides the first molecular link between NO free radicals and protein misfolding, which is currently thought to be a common pathway in the pathogenesis of virtually all neurodegenerative conditions. Such conditions also include ALS (or Lou Gehrig's disease), Huntington's disease, and many others.
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