Trusted by:
Genomic instability, particularly in the regions at the ends of the chromosomes known as telomeres, has been linked to aging and cancer. Now, researchers have shown that an enzyme known as Ubp10 plays a vital role in protecting the telomeric regions of the genome from potential destabilizing molecular events.
This study reports on how mutations in p53 lead to DNA replication stress. This stress leads to random errors in the DNA duplication process. Unless halted, this error-generating process leads to an accumulation of mutant genes in the cell and, eventually, cancer.
Familiar preventive vaccines protect an individual from infections. Therapeutic vaccines, however, are designed for patients who have acquired chronic infections, such as HIV or hepatitis, or even cancers. Thus far, such vaccines have fallen short of expectations.
A new study offers insights into the intricate biochemistry governing gene regulation, while simultaneously pointing to the importance of investigating the complex biology of life at different levels of organization.
The cancer gene MYC is among the most commonly overexpressed oncogenes in human cancers. Scientists at The Wistar Institute have now shown that MYC activates a gene called MTA1, which has been demonstrated by other researchers to regulate metastasis in a variety of cancers.
A team of scientists has detailed the convergence of RNA editing and microRNAs. MicroRNAs are involved in embryonic development, cell and tissue formation, and cancer formation. The study expands understanding of the role of RNA editing in gene control.
In diverse ecosystems, packed with wildly different species, evolution whizzes along. As different species accumulate mutations, some adapt particularly well to their environment and prosper. It happens in marine sediments, mountain forests "鈥� and, as a new study illustrates, in precancerous tumors, too.
A novel approach to creating a vaccine to treat melanoma has demonstrated promising effectiveness in a new laboratory study led by researchers at The Wistar Institute. About a third of melanoma patients might benefit from such a vaccine.
Only about 10 percent of the roughly 25,000 genes in the human genome are activated, or "on,"聺 at any given time in a particular cell "鈥� the default setting for most genes is "off,"聺 or repressed. Reliable gene silencing is vital to the health of an organism. In a new study, researchers have identified an important new global mechanism for this essential gene silencing.
A new study shows that an enzyme involved in appropriately repressing sets of neuronal genes in non-neuronal cells is also a target for certain monoamine oxidase inhibitors used to treat depression. The findings suggest that these anti-depressive drugs may have additional applications in other medically relevant areas. Specifically, the anti-cancer possibilities of these drugs are currently being explored.
RSS
Medicine keyboard_arrow_right
Sciencekeyboard_arrow_right
Life keyboard_arrow_right
Business keyboard_arrow_right
Journal 麻豆传媒 keyboard_arrow_right
By Location keyboard_arrow_right
Meetings, Grants, and Events keyboard_arrow_right