The January 2025 issue of focuses on inflammation with articles and reviews across a broad array of digestive diseases, including an updated ACG Clinical Guideline on eosinophilic esophagitis (EoE). Co-Editors-in-Chief Dr. Jasmohan Bajaj and Dr. Millie Long write that, “Each inflammatory disorder or complication we discuss has a differing etiology, diagnostic work-up, and treatment strategy, yet are bound by the underlying inflammatory pathology. The broad variability in both the consequences and diagnosis of inflammation across the digestive system is highlighted throughout this issue.”
This month we published articles on the areas of EoE, inflammatory bowel disease (IBD), acute pancreatitis, gastritis, cirrhosis, gastroesophageal reflux, and more. Several articles are highlighted below and access to any articles from this issue, or past issues, is available upon request. The College is also able to connect members of the press with study authors or outside experts who can comment on the articles.
Dellon, et al.
This update to the ACG Clinical Guideline on EoE features 19 recommendations. These include strong recommendations of the use of a systematic endoscopic scoring system at each endoscopy to describe findings, and use of swallowed topical steroids for EoE treatment. Conditional recommendations include use of proton pump inhibitors and use of fluticasone propionate or budesonide for patients treated with topical steroids. They also outline recommendations for pediatric-specific concerns of EoE.
with first author Dr. Evan Dellon (19:16)
Visual Summary
Cho, et al.
This nationwide cohort study assessed the risk of gestational diabetes mellitus (GDM) associated with anti-tumor necrosis factor (anti-TNF) treatment among pregnant women with IBD. They found a decreased risk of GDM among patients who used anti-TNFs during early pregnancy compared to those who did not.
Lee, et al.
In a prospective, multicenter study, the authors asked patients with ulcerative colitis scheduled to undergo endoscopy for mucosal inflammation monitoring to take smartphone photos of their stool within one week of their endoscopy date. They defined endoscopic activity using the UC endoscopic index of severity and compared these to fecal calprotectin results. They found that the deep learning model achieved similar discriminating power to Fcal in predicting endoscopic activity.
About the American College of Gastroenterology
Founded in 1932, the American College of Gastroenterology (ACG) is an organization with an international membership of over 19,000 individuals from 86 countries. The College's vision is to be the preeminent organization supporting health care professionals who provide compassionate, equitable, high-quality, state-of-the-art, and personalized care to promote digestive health. The mission of the College is to provide tools, services, and accelerate advances in patient care, education, research, advocacy, practice management, professional development and clinician wellness, enabling our members to improve patients’ digestive health and to build personally fulfilling careers that foster well-being, meaning and purpose. Follow ACG on Bluesky and X @AmCollegeGastro and learn more at .
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