Scientists have unveiled a revolutionary method for mass-producing high-quality human mitochondria, potentially transforming treatments for degenerative diseases. By refining stem cell culture conditions, researchers achieved an extraordinary 854-fold increase in mitochondrial production while significantly enhancing energy output.
BACKGROUNDAcute lung injury (ALI) is a fatal and heterogeneous disease. While bone marrow mesenchymal stem cells (BMSCs) have shown promise in ALI repair, their efficacy is compromised by a high apoptotic percentage. Preliminary findings ha
Acute kidney injury (AKI) is a clinical syndrome characterized by a rapid deterioration in kidney function and has a significant impact on patient health and survival. Mesenchymal stem cells (MSCs) have the potential to enhance renal functi
BACKGROUNDAnkylosing spondylitis (AS) is recognized as a long-term inflammatory disorder that leads to inflammation in the spine and joints, alongside abnormal bone growth. In previous studies, we reported that mesenchymal stem cells (MSCs)
Exosomes (Exos) are extracellular vesicles secreted by cells and serve as crucial mediators of intercellular communication. They play a pivotal role in the pathogenesis and progression of various diseases and offer promising avenues for the
Xiao et al reported on the natural product sinomenine (SIN), which is a traditional Chinese medicine for treating osteoporosis via its modulation of autophagy; however, SIN was dissolved in dimethyl sulfoxide prior to administration, which
BACKGROUNDCervical cancer (CC) stem cell-like cells (CCSLCs), defined by the capacity of differentiation and self-renewal and proliferation, play a significant role in the progression of CC. However, the molecular mechanisms regulating thei
BACKGROUNDHeart disease remains a leading cause of mortality worldwide, with existing treatments often failing to effectively restore damaged myocardium. Human-induced pluripotent stem cells (hiPSCs) and their derivatives offer promising th
This article discusses the study by Xiao et al, which investigated the therapeutic efficacy of serum-free cultured human umbilical cord mesenchymal stem cells (N-hUCMSCs) in a mouse model of knee osteoarthritis. The results showed that N-hU
BACKGROUNDAs living biodrugs, mesenchymal stem cells (MSCs) have progressed to phase 3 clinical trials for cardiovascular applications. However, their limited immediate availability hampers their routine clinical use. AIMTo validate our hy
BACKGROUNDMesenchymal stem cells (MSCs) and their secretome have significant potential in promoting hair follicle development. However, the effects of MSC therapy have been reported to vary due to their heterogeneous characteristics. Differ
NASA Awards NSCF $3.1M to Continue Studying Effects of Microgravity on Brain Cells
Scientists from Johns Hopkins Medicine and eight other institutions in the United States, Africa and Europe say they have identified a potential new gene target that could be edited to treat sickle cell disease, an inherited blood disorder marked by sickle-shaped red blood cells that cause intense pain and shorten lifespans.
A transformative study has uncovered the pivotal role of the protein Naked cuticle homolog 2 (NKD2) in regulating the differentiation of bone-forming osteoblasts and bone-resorbing osteoclasts. This discovery opens up new possibilities in the fight against bone loss, particularly in postmenopausal osteoporosis.
A stem cell therapy trial aimed at reducing neuroinflammation in patients with presymptomatic Alzheimer鈥檚 disease is underway at UTHealth Houston.
In a preclinical study, researchers at Children鈥檚 Hospital of Philadelphia (CHOP) demonstrated a novel gene therapy with potentially increased effectiveness and safety for the treatment for metachromatic leukodystrophy (MLD), a rare disease in young children characterized by the deficient activity of a critical enzyme.
A modified bone marrow transplant procedure for sickle cell disease (SCD) co-developed at Vanderbilt University Medical Center, Johns Hopkins University School of Medicine, and the University of California, San Francisco, can cure the disease, a new study has found.
A multidisciplinary team of Cedars-Sinai investigators has used a novel single-cell proteomics approach to better understand the differences between naturally occurring adult heart cells and heart cells derived from induced pluripotent stem cells.
The SXSW Conference will take place from March 7-15 in Austin, Texas, bringing together a vibrant mix of ideas and innovations. Once again, UC San Diego will take center stage, showcasing cutting-edge research, transformative discussions on critical global challenges and a film premiere.
UCLA scientists have identified a potential new strategy for treating glioblastoma, the deadliest form of brain cancer, by reprogramming aggressive cancer cells into harmless ones.
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