A research team at UVA Health is testing the ability of focused ultrasound to increase the immune response to immunotherapy in melanoma. UVA鈥檚 work with focused ultrasound already has led to life-changing new treatments for Parkinson鈥檚 disease and essential tremor and pushed the technology to the forefront of medical research.
Scientists have long been trying to tease apart hepatitis A virus, to understand its inner workings and how it functions in the human body. Infectious disease researchers at the UNC School of Medicine have discovered that a little-known protein, PDGFA-associated protein 1 (PDAP1), is used as a pawn by hepatitis A virus to replicate and infect cells in the liver.
The Wistar Institute scientists have discovered a new approach to treating ovarian cancer that, in preclinical laboratory testing, shrinks tumors and improves survival rates while simultaneously making tumors more receptive to chemotherapy treatment.
New research from Memorial Sloan Kettering Cancer Center (MSK)& investigates how pancreatic cancer cells regulate their genome to avoid immune attack; shows promise against glioblastoma in mouse models; and develops a new method to study cancer evolution.
In work published in Nature, researchers鈥� structural insights help reveal a weak spot in malaria鈥檚 plan of attack which could help guide vaccine design.
Sean Crosson, a Professor Rudolph Hugh Endowed Chair in Michigan State University鈥檚 Department of Microbiology, Genetics and Immunology, has been awarded a $2.4 million grant from the National Institutes of Health鈥檚 National Institute of Allergy and Infectious Diseases to study the cause of that very disease, Brucella abortus.
La Jolla Institute for Immunology (LJI) and Link Campus University of Rome, Italy, and have signed a collaborative agreement as part of a strategic program aimed at promoting scientific research and innovation between the United States and Italy.
La influenza puede ser una enfermedad desagradable de una semana de duraci贸n y un inconveniente para muchas personas, pero puede tener consecuencias graves para los adultos mayores.
Ryan Teague, Ph.D., professor of molecular microbiology and immunology at Saint Louis University鈥檚 School of Medicine, and his team are now trying to uncover the exact mechanism underlying the metabolic dysfunctions associated with obesity that directly impact T-cell function.
The study findings point to the potential of interleukin-13 antibodies 鈥� approved for use in humans 鈥� as a treatment to protect against bacterial pneumonia in patients with zinc deficiency.
Results from a new animal study published in the American Journal of Physiology-Lung Cellular and Molecular Physiology found that maternal exposure to e-cigarette residues, with or without nicotine, affected offspring鈥檚 immune response later in life.
A new drug strategy that regulates the tumor immune microenvironment may transform a tumor that resists immunotherapy into a susceptible one, according to a study by researchers from the Johns Hopkins Kimmel Cancer Center and Oregon Health & Science University.
Researchers have identified new roles for a protein long known to protect against severe flu infection 鈥� among them, raising the minimum number of viral particles needed to cause sickness.
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A la mayor铆a de la gente no le gusta aplicarse vacunas o inyecciones para recibir tratamientos. Por eso, los investigadores trabajan para crear m谩s medicamentos, como los que se fabrican a partir de ARN mensajero (ARNm), que puedan pulverizarse e inhalarse. Un estudio publicado en la revista Journal of the American Chemical Society informa sobre los avances para hacer posible los medicamentos de ARNm inhalables. Los investigadores indican que la nanopart铆cula de pol铆mero lip铆dico, que es estable cuando se nebuliza y libera aerosoles (gotitas l铆quidas) en los pulmones de ratones de forma satisfactoria, se optimiz贸 para contener el ARNm.
The use of biologic and targeted therapies for children with juvenile idiopathic arthritis (JIA) surpassed more typical therapies in recent years, according to Rutgers Health researchers.
These miniature immune system models 鈥� known as human immune organoids 鈥� mimic the real-life environment where immune cells learn to recognize and attack harmful invaders and respond to vaccines. Not only are these organoids powerful new tools for studying and observing immune function in cancer, their use is likely to accelerate vaccine development, better predict disease treatment response for patients, and even speed up clinical trials.
UCLA investigators have shown that that combining pembrolizumab, an immunotherapy drug, with standard chemotherapy can improve treatment outcomes for patients with small cell bladder cancer and small cell/neuroendocrine prostate cancer.
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