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News — While it’s known that sleep plays a crucial role in strengthening memory, scientists are still trying to decode how this process plays out in the brain overnight.

New research led by scientists at UCLA Health and Tel Aviv University provides the first physiological evidence from inside the human brain supporting the dominant scientific theory on how the brain consolidates memory during sleep. Further, the researchers found that targeted deep-brain stimulation during a critical time in the sleep cycle appeared to improve memory consolidation.

The research, published June 1 in Nature Neuroscience, could offer new clues for how deep-brain stimulation during sleep could one day help patients with memory disorders like Alzheimer’s disease, said study co-author . This was achieved by a novel “closed-loop” system that delivered electrical pulses in one brain region precisely synchronized to brain activity recorded from another region.

According to the dominant theory for how the brain converts new information into long-term memories during shuteye, there’s an overnight dialogue between the hippocampus – the brain’s memory hub – and the cerebral cortex, which is associated with higher brain functions like reasoning and planning. This occurs during a phase of deep sleep, when brain waves are especially slow and neurons across brain regions alternate between rapidly firing in sync and silence.

“This provides the first major evidence down to the level of single neurons that there is indeed this mechanism of interaction between the memory hub and the entire cortex,” said Fried, the director of epilepsy surgery at UCLA Health and professor of neurosurgery, psychiatry and biobehavioral sciences at the “It has both scientific value in terms of understanding how memory works in humans and using that knowledge to really boost memory.”

The researchers had a unique opportunity to test this theory of memory consolidation via electrodes in the brains of 18 epilepsy patients at UCLA Health. The electrodes had been implanted in the patients’ brains to help identify the source of their seizures during hospital stays typically lasting around 10 days.

The study was conducted across two nights and mornings. Just before bedtime, study participants were shown photo pairings of animals and 25 celebrities, including easily identifiable stars like Marilyn Monroe and Jack Nicholson. They were immediately tested on their ability to recall which celebrity was paired with which animal, and they were tested again in the morning after a night of undisturbed sleep.

On another night, they were shown 25 new animal and celebrity pairings before bedtime. This time, they received targeted electrical stimulation overnight, and their ability recall the pairings was tested in the morning. To deliver this electrical stimulation, the researchers had created a real-time closed-loop system that Fried likened to a musical conductor: The system “listened” to brain’s electrical signals, and when patients fell into the period of deep sleep associated with memory consolidation, it delivered gentle electrical pulses instructing the rapidly firing neurons to “play” in sync.

Each individual tested performed better on memory tests following a night of sleep with the electrical stimulation compared to a night of undisturbed sleep. Key electrophysiological markers also indicated that information was flowing between the hippocampus and throughout the cortex, providing physical evidence supporting of memory consolidation.

“We found we basically enhanced this highway by which information flows to more permanent storage places in the brain,” Fried said.

Fried in 2012 authored a that for the first time showed that electrical stimulation can strengthen memory, and his work has continued to explore how deep brain stimulation could improve memory, now moving into the critical stage of sleep. He recently received a to study whether artificial intelligence can help pinpoint and strengthen specific memories in the brain.

“In our new study, we showed we can enhance memory in general,” Fried said. “Our next challenge is whether we have the ability to modulate specific memories.”

Yuval Nir of Tel Aviv University co-supervised the study with Fried. Other authors include lead author Maya Geva-Sagiv, as well as Emily Mankin, Dawn Eliashiv, Natalie Cherry, Guldamla Kalender and Natalia Tchemodanov from UCLA, and Shdema Epstein from Tel-Aviv University.

Geva-Sagic, Nir and Fried are co-inventors of a U.S. patent related to this study. The authors declared no other competing interests.

This study was supported by research grants from the National Science Foundation and U.S.-Israel Binational Science Foundation (1756473, 2017628), National Institute of Neurological Disorders and Stroke (U01 grants NS108930 and NS123128, R01-NS084017) and European Research Council (ERC-2019-CoG 864353). Please see the study for additional funding details.