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News — Exosomes derived from hypoxic endometrial epithelial cells are pivotal in cellular communication and tissue repair, offering new perspectives on reproductive health. This manuscript highlights the study by Zhang et al, which investigates the effects of miR-214-5p and miR-21-5p in hypoxic cell-derived exosomes on human umbilical cord mesenchymal stem cells. The study reveals that low levels of these microRNAs activate the signal transducer and activator of transcription 3 signaling pathway, enhancing human umbilical cord mesenchymal stem cell migration and differentiation. These findings provide novel insights into therapeutic strategies for improving endometrial health and addressing infertility linked to thin endometrium.

Core Tip: This manuscript examines the study by Zhang et al on the effects of miR-214-5p and miR-21-5p in hypoxic endometrial epithelial-cell-derived exosomes on human umbilical cord mesenchymal stem cells. The study highlights how low expression levels of these microRNAs activate the signal transducer and activator of transcription 3 signaling pathway, promoting human umbilical cord mesenchymal stem cell migration and differentiation - key processes in tissue repair and regeneration. These findings offer new insights into addressing thin endometrium, a common cause of infertility, by leveraging exosome-based therapies or targeted microRNA modulation. This article underscores the potential of miR-214-5p and miR-21-5p as therapeutic targets for improving endometrial health and reproductive outcomes.

• Citation: Zhang JW. Impact of miR-214-5p and miR-21-5p from hypoxic endometrial exosomes on human umbilical cord mesenchymal stem cell function. World J Stem Cells 2025; 17(2): 102404
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