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News — DALLAS – April 16, 2025 – High levels of physical activity may mitigate brain loss in adults and help maintain long-term cognitive health, researchers at UT Southwestern Medical Center report in a study published in the .

“Age-related brain atrophy is one of the significant risk factors for Alzheimer’s disease and related dementias (ADRD),” said senior author , Professor of , , and  at UT Southwestern and an Investigator in the . “This study suggests that engaging in activity to improve one’s physical fitness may reduce the risk of ADRD.”

ADRD is a set of debilitating conditions that impair memory, thought processes, and functioning, primarily among older adults. More than 6 million people in the U.S. have ADRD, and the Centers for Disease Control and Prevention projects the potential for nearly 14 million adults in the U.S. to have Alzheimer’s by 2060.

Researchers examined data from 172 sedentary yet healthy adults between the ages of 22 and 81 from the Dallas-Fort Worth area. Each participant underwent a cardiorespiratory fitness (CRF) test, cognitive testing, and MRI scans. Peak oxygen consumption was monitored and used to measure CRF, with higher peak oxygen consumption reflecting better CRF. 

Among participants, researchers found that aging was associated with smaller gray matter volumes and thickness of the cerebral cortex.

After controlling for sex, years of education, total intracranial volume, and peak oxygen consumption, statistical analyses also revealed that aging was associated with lower volume in the right superior parietal area of the brain in those who had lower peak oxygen consumption, but not in those with higher peak oxygen consumption. Notably, the right superior parietal region of the brain plays an important role in fluid cognitive function, and researchers found that larger right superior parietal volume was linked to better cognitive function such as inductive reasoning, long-term memory, working memory, and verbal fluency.

Researchers also found the weaker relationship between age and right superior parietal volume in the higher peak oxygen consumption group was present in both men and women, which suggests high levels of cardiorespiratory fitness may mitigate deterioration of brain volume and preserve cognitive function in both men and women.

“The findings from this study support the hypothesis that engaging in lifelong physical activity to improve physical fitness may prevent or slow brain aging and ADRD,” Dr. Zhang said.

Lead author Junyeon Won, Ph.D., is a UTSW postdoctoral research fellow in the Institute for Exercise and Environmental Medicine at Texas Health Presbyterian Dallas. Dr. Zhang is Director of the Cerebrovascular Laboratory at the Institute for Exercise and Environmental Medicine. Three researchers at UT Dallas also collaborated on the study, performing cognitive function assessments.

This research was supported by grants from the National Institutes of Health (R01HL102457, R01AG033106).

About UT Southwestern Medical Center   

UT Southwestern, one of the nation’s premier academic medical centers, integrates pioneering biomedical research with exceptional clinical care and education. The institution’s faculty members have received six Nobel Prizes and include 25 members of the National Academy of Sciences, 23 members of the National Academy of Medicine, and 14 Howard Hughes Medical Institute Investigators. The full-time faculty of more than 3,200 is responsible for groundbreaking medical advances and is committed to translating science-driven research quickly to new clinical treatments. UT Southwestern physicians provide care in more than 80 specialties to more than 120,000 hospitalized patients, more than 360,000 emergency room cases, and oversee nearly 5 million outpatient visits a year.