While Alzheimer鈥檚 Disease is traditionally associated with the buildup of plaques, emerging evidence suggests that mitochondrial dysfunction may play a role in the onset and progression of this devastating neurodegenerative disorder.
A review article entitled 鈥淧revalence of Antibiotic Resistance in Older Adults and Alzheimer鈥檚 Disease Patients: A Systematic Review and Meta-Analysis,鈥� is now published in the Journal Alzheimer鈥檚 Disease Reports.
Researchers working with the Alzheimer鈥檚 Center at Temple (ACT) recently investigated the effect of extra virgin olive oil (EVOO) on brain health and memory to determine if consumption of extra virgin olive oil, the main component of the Mediterranean diet, can delay cognitive decline in people with Down Syndrome (DS).
People aged 60-80 with low levels of the protein ABCA7 in the brain appear more likely to develop Alzheimer鈥檚 disease, according to a new study published in the Journal of Neuropathology & Experimental Neurology.
鈥淎I-driven neuroimaging techniques have the potential to improve prediction models for Alzheimer鈥檚 progression and facilitate personalized treatment strategies,鈥� says Domenico Pratic貌, MD, the Scott Richards North Star Foundation Chair for Alzheimer鈥檚 Research, Professor in the Departments of Pharmacology and Microbiology, and Director of the Alzheimer鈥檚 Center at Temple (ACT), at the Lewis Katz School of Medicine at Temple University (LKSOM).
鈥淎re the risk factors for early onset Alzheimer鈥檚 the same as late onset?鈥� asks Domenico Pratic貌, MD, the Scott Richards North Star Foundation Chair for Alzheimer鈥檚 Research, Professor in the Departments of Pharmacology and Microbiology, and Director of the Alzheimer鈥檚 Center at Temple (ACT), at the Lewis Katz School of Medicine at Temple University (LKSOM)
Clinical studies suggest the Mediterranean diet, and one of its main components, extra virgin olive oil (EVOO), improves cognitive function and slows Alzheimer's disease (AD) progression. Researchers will now investigate whether this is true even for people with a family history of AD and signs of genetic predisposition caused by dysfunction in the APOE gene.
The test alone will not provide enough information to reach a diagnosis of memory problems/cognitive decline. Only a trained physician can do it.
Since 2012, September has been celebrated as World Alzheimer鈥檚 Month. Back then, and only eleven years ago, an average of 2 out of 3 people had little understanding of Alzheimer's disease and associated dementias.
鈥淭here is abundant evidence of a link between contact sports, such as football, and dementia later in life,鈥� comments Domenico Pratico, M.D., Director of the Alzheimer鈥檚 Center at Temple University (ACT).
A recent study shows that a protein called ABCA7 plays a functional role as a potential biological link between cholesterol and inflammation in Alzheimer鈥檚 disease. The new work was published online August 25 in the journal Cells.
A recent study has used Artificial Intelligence (AI) to reveal the remarkable potential of extra virgin olive oil (EVOO) in the fight against Alzheimer's disease (AD). Researchers combined AI technology, chemistry, and omics research to identify specific bioactive compounds in EVOO that show promising effects in treating and preventing AD.
A new approach could enhance memory and learning in individuals with Down syndrome by stabilizing a key component in the body's protein sorting system called the retromer complex.
A biomarker is a characteristic that can be measured and evaluated as an indicator of normal biological processes, pathogenetic processes, or pharmacologic responses to a therapeutic intervention. In the context of Alzheimer鈥檚 disease (AD), an AD biomarker indicates the presence or progression of the disease that may be altered by drug treatment, thereby demonstrating that it is hitting its target. Today, all clinical trials for Alzheimer鈥檚 disease utilize biomarkers of some form to assess whether the drug is actually affecting the disease in the brain.
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