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Released: 8-Nov-2024 1:05 PM EST
PIM-1L Kinase Binds to and Inactivates SRPK1: A Biochemical and Molecular Dynamics Study
National Center For Scientific Research Demokritos

SR/RS dipeptide repeats vary in both length and position, and are phosphorylated by SR protein kinases (SRPKs). PIM-1L, the long isoform of PIM-1 kinase, the splicing of which has been implicated in acute myeloid leukemia, contains a domain that consists largely of repeating SR/RS and SH/HS dipeptides (SR/SH-rich).

Released: 8-Nov-2024 12:45 PM EST
Polymorphic Positions 349 and 725 of the Autoimmunity-Protective Allotype 10 of ER Aminopeptidase 1 Are Key in Determining Its Unique Enzymatic Properties
National Center For Scientific Research Demokritos

ER aminopeptidase 1 (ERAP1) is a polymorphic intracellular aminopeptidase with key roles in antigen presentation and adaptive immune responses. ERAP1 allotype 10 is highly protective toward developing some forms of autoimmunity and displays unusual functional properties, including very low activity versus some substrates.

Released: 23-Oct-2024 3:05 AM EDT
43rd International Symposium on Physics in Collision
National Center For Scientific Research Demokritos

The International Symposium on Physics in Collision, initiated in 1981, is a prominent conference series focused on particle physics. It features invited plenary talks, parallel sessions, and poster presentations, with a strong emphasis on recent experimental results and theoretical developments.



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